Integral rein control in physiology II: A general model

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dc.contributor.authorSaunders P.T.
dc.contributor.authorKoeslag J.H.
dc.contributor.authorWessels J.A.
dc.date.accessioned2011-05-15T15:59:51Z
dc.date.available2011-05-15T15:59:51Z
dc.date.issued2000
dc.description.abstractWe generalize the principle of integral rein control to include other systems which partition in such a way that the equilibrium values of some variables are not dependent on the equations governing those variables. Instead, they are determined by the dynamics of other, 'regulator' variables. We improve our earlier model for the control of glucose by insulin and glucagon by relaxing the condition necessary for it to operate. The two hormones do not have to be inhibited in the same way; they need only respond to the same combination of their concentrations. We also present a model for the control of ionized calcium by PTH and calcitonin and suggest that the role of chromogranin A may be to stabilize an otherwise unstable system. (C) 2000 Academic Press.
dc.description.versionArticle
dc.identifier.citationJournal of Theoretical Biology
dc.identifier.citation206
dc.identifier.citation2
dc.identifier.issn225193
dc.identifier.other10.1006/jtbi.2000.2118
dc.identifier.urihttp://hdl.handle.net/10019.1/11395
dc.subjectcalcitonin
dc.subjectcalcium
dc.subjectchromogranin A
dc.subjectglucagon
dc.subjectglucose
dc.subjectinsulin
dc.subjectparathyroid hormone
dc.subjectarticle
dc.subjectcalcium metabolism
dc.subjectequilibrium constant
dc.subjectglucose metabolism
dc.subjecthormonal regulation
dc.subjectmathematical model
dc.subjectmolecular dynamics
dc.subjectpriority journal
dc.subjectregulatory mechanism
dc.subjectBlood Glucose
dc.subjectCalcitonin
dc.subjectCalcium
dc.subjectGlucagon
dc.subjectHuman
dc.subjectInsulin
dc.subjectModels, Biological
dc.subjectParathyroid Hormones
dc.titleIntegral rein control in physiology II: A general model
dc.typeArticle
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