Transcriptional regulation and the diversification of metabolism in wine yeast strains

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dc.contributor.authorRossouw, D.en_ZA
dc.contributor.authorJacobson, D.en_ZA
dc.contributor.authorBauer, Florianen_ZA
dc.date.accessioned2012-02-07T13:43:17Z
dc.date.available2012-02-07T13:43:17Z
dc.date.issued2012
dc.description.abstractTranscription factors and their binding sites have been proposed as primary targets of evolutionary adaptation because changes to single transcription factors can lead to far-reaching changes in gene expression patterns. Nevertheless, there is very little concrete evidence for such evolutionary changes. Industrial wine yeast strains, of the species Saccharomyces cerevisiae, are a geno- and phenotypically diverse group of organisms that have adapted to the ecological niches of industrial winemaking environments and have been selected to produce specific styles of wine. Variation in transcriptional regulation among wine yeast strains may be responsible for many of the observed differences and specific adaptations to different fermentative conditions in the context of commercial winemaking. We analyzed gene expression profiles of wine yeast strains to assess the impact of transcription factor expression on metabolic networks. The data provide new insights into the molecular basis of variations in gene expression in industrial strains and their consequent effects on metabolic networks important to wine fermentation. We show that the metabolic phenotype of a strain can be shifted in a relatively predictable manner by changing expression levels of individual transcription factors, opening opportunities to modify transcription networks to achieve desirable outcomes. © 2012 by the Genetics Society of America.
dc.identifier.citationGenetics
dc.identifier.citation190
dc.identifier.citation1
dc.identifier.citation251
dc.identifier.citation261
dc.identifier.issn166731
dc.identifier.other10.1534/genetics.111.132720
dc.identifier.urihttp://hdl.handle.net/10019.1/19620
dc.titleTranscriptional regulation and the diversification of metabolism in wine yeast strains
dc.typeArticle
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