Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
AOSIS
Abstract
ENGLISH ABSTRACT: Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage of colistin-resistant Escherichia coli and Klebsiella spp. and mcr genes in children from communities in Cape Town. Colistin-resistant E. coli was isolated from two participants (4%, 2/50), and mcr-1-mcr-9 genes were not detected. Gastrointestinal carriage of colistin-resistant Enterobacterales was rare; however, continuous extensive surveillance is necessary to determine the extent of carriage and its contribution to resistance observed in clinical settings.
Description
CITATION: Snyman, Y., et al. 2021. Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study). Southern African Journal of Infectious Diseases, 36(1):a241, doi:10.4102/sajid.v36i1.241.
The original publication is available at https://sajid.co.za
Publication of this article was funded by the Stellenbosch University Open Access Fund
The original publication is available at https://sajid.co.za
Publication of this article was funded by the Stellenbosch University Open Access Fund
Keywords
Enterobacterales, Antibacterial agents, Gram-negative bacteria, Tuberculosis in children, Colistin, Multidrug resistance
Citation
Snyman, Y., et al. 2021. Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study). Southern African Journal of Infectious Diseases, 36(1):a241, doi:10.4102/sajid.v36i1.241