Fulminanting necrotising enterocolitis: Outcome and prognostic factors

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dc.contributor.authorVoss M.
dc.contributor.authorMoore S.W.
dc.contributor.authorVan Der Merwe I.
dc.contributor.authorPieper C.
dc.date.accessioned2011-05-15T16:03:46Z
dc.date.available2011-05-15T16:03:46Z
dc.date.issued1998
dc.description.abstractIn order to determine the outcome of infants with fulminant necrotising entercolitis (NEC), the records of 128 surgically-treated neonates were reviewed. Fifty-two were found to have severe, rapid-onset disease. The 30-day survival was determined and correlated with birth weight, gestational age, laboratory and radiological findings, and extent of disease. Seven patients did not respond to resuscitative measures and were treated by percutaneous drainage with a uniformly fatal outcome. For patients who could be made fit for surgery, the only absolute predictor of survival was extent of disease. Pannecrosis occurred in 19 patients and all of these died. Conversely, patients who had resectable disease had a 30-day survival of 61%. Pan-necrosis could not be determined preoperatively by radiological findings. Patients with severe, rapid-onset NEC and evidence of gangrene who respond to resuscitation should have active surgical management, as approximately one-half of them have resectable disease and a reasonable short-term outcome may be expected. Patients who do not respond to resuscitative measures and those with a surgical finding of pan-necrosis had a uniformly fatal outcome in this study, and if resources are limited, it is reasonable to withdraw active management in this group of patients.
dc.description.versionArticle
dc.identifier.citationPediatric Surgery International
dc.identifier.citation13
dc.identifier.citation8
dc.identifier.issn1790358
dc.identifier.other10.1007/s003830050407
dc.identifier.urihttp://hdl.handle.net/10019.1/12776
dc.subjectarticle
dc.subjectbirth weight
dc.subjectdisease course
dc.subjectenterocolitis
dc.subjectfatality
dc.subjectgestational age
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectnewborn
dc.subjectpercutaneous drainage
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectAnalysis of Variance
dc.subjectEnterocolitis, Necrotizing
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectPostoperative Complications
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.subjectTreatment Outcome
dc.titleFulminanting necrotising enterocolitis: Outcome and prognostic factors
dc.typeArticle
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