Cross-species chromosome painting in the golden mole and elephant-shrew: Support for the mammalian clades Afrotheria and Afroinsectiphillia but not Afroinsectivora

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dc.contributor.authorRobinson T.J.
dc.contributor.authorFu B.
dc.contributor.authorFerguson-Smith M.A.
dc.contributor.authorYang F.
dc.date.accessioned2011-05-15T16:00:25Z
dc.date.available2011-05-15T16:00:25Z
dc.date.issued2004
dc.description.abstractCross-species painting (fluorescence in situ hybridization) with 23 human (Homo sapiens (HSA)) chromosome-specific painting probes (HSA 1-22 and the X) was used to delimit regions of homology on the chromosomes of the golden mole (Chrysochloris asiaticus) and elephant-shrew (Elephantulus rupestris). A cladistic interpretation of our data provides evidence of two unique associations, HSA 1/19p and 5/21/3, that support Afrotheria. The recognition of HSA 5/3/21 expands on the 3/21 synteny originally designated as an ancestral state for all eutherians. We have identified one adjacent segment combination (HSA2/8p/4) that is supportive of Afroinsectiphillia (aardvark, golden mole, elephant-shrew). Two segmental combinations (HSA 10q/17 and HSA 3/20) unite the aardvark and elephant-shrews as sister taxa. The finding that segmental syntenies in evolutionarily distant taxa can improve phylogenetic resolution suggests that they may be useful for testing sequence-based phylogenies of the early eutherian mammals. They may even suggest clades that sequence trees are not recovering with any consistency and thus encourage the search for additional rare genomic changes among afrotheres.
dc.description.versionArticle
dc.identifier.citationProceedings of the Royal Society B: Biological Sciences
dc.identifier.citation271
dc.identifier.citation1547
dc.identifier.issn9628452
dc.identifier.other10.1098/rspb.2004.2754
dc.identifier.urihttp://hdl.handle.net/10019.1/11689
dc.subjectchromosome
dc.subjectcladistics
dc.subjectphylogenetics
dc.subjectsmall mammal
dc.subjectafroinsectiphilia
dc.subjectafroinsectivora
dc.subjectafrotheria
dc.subjectallele
dc.subjectanimal cell
dc.subjectarticle
dc.subjectchrysochloris asiaticus
dc.subjectcladistics
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectcross breeding
dc.subjectdata analysis
dc.subjectelephant shrew
dc.subjectelephantulus rupestris
dc.subjectfluorescence analysis
dc.subjectgenetic analysis
dc.subjectgenetic cross
dc.subjectin situ hybridization
dc.subjectinsectivore
dc.subjectmammal
dc.subjectmolecular evolution
dc.subjectmolecular phylogeny
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectsequence homology
dc.subjectAnimals
dc.subjectChromosome Painting
dc.subjectChromosomes, Mammalian
dc.subjectDNA Probes
dc.subjectHumans
dc.subjectKaryotyping
dc.subjectMoles
dc.subjectPhylogeny
dc.subjectShrews
dc.subjectSynteny
dc.subjectAnimalia
dc.subjectChrysochloridae
dc.subjectChrysochloris
dc.subjectelephant
dc.subjectElephantulus rupestris
dc.subjectEutheria
dc.subjectHomo
dc.subjectHomo sapiens
dc.subjectMammalia
dc.subjectSoricidae
dc.titleCross-species chromosome painting in the golden mole and elephant-shrew: Support for the mammalian clades Afrotheria and Afroinsectiphillia but not Afroinsectivora
dc.typeArticle
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