Hoarding in obsessive-compulsive disorder: Clinical and genetic correlates
dc.contributor.author | Lochner C. | |
dc.contributor.author | Kinnear C.J. | |
dc.contributor.author | Hemmings, Sian M. J. | en_ZA |
dc.contributor.author | Seller C. | |
dc.contributor.author | Niehaus D.J.H. | |
dc.contributor.author | Knowles J.A. | |
dc.contributor.author | Daniels W. | |
dc.contributor.author | Moolman-Smook J.C. | |
dc.contributor.author | Seedat S. | |
dc.contributor.author | Stein D.J. | |
dc.date.accessioned | 2011-05-15T16:01:56Z | |
dc.date.available | 2011-05-15T16:01:56Z | |
dc.date.issued | 2005 | |
dc.description.abstract | Objective: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation. Method: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004. Results: OCD patients with hoarding made up 18.1% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls. Conclusions: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here. | |
dc.description.version | Article | |
dc.identifier.citation | Journal of Clinical Psychiatry | |
dc.identifier.citation | 66 | |
dc.identifier.citation | 9 | |
dc.identifier.issn | 1606689 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/12227 | |
dc.subject | DNA | |
dc.subject | adult | |
dc.subject | Africa | |
dc.subject | article | |
dc.subject | Caucasian | |
dc.subject | clinical feature | |
dc.subject | comorbidity | |
dc.subject | controlled study | |
dc.subject | female | |
dc.subject | genetic analysis | |
dc.subject | genetic polymorphism | |
dc.subject | genotype | |
dc.subject | human | |
dc.subject | interview | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | Obsessive-compulsive disorder | en_ZA |
dc.subject | priority journal | |
dc.subject | scoring system | |
dc.subject | venous blood | |
dc.subject | Adult | |
dc.subject | Catechol O-Methyltransferase | |
dc.subject | Child | |
dc.subject | Child Abuse | |
dc.subject | Comorbidity | |
dc.subject | Diagnostic and Statistical Manual of Mental Disorders | |
dc.subject | Disability Evaluation | |
dc.subject | Ethnic Groups | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Female | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Mental Disorders | |
dc.subject | Obsessive-Compulsive Disorder | |
dc.subject | Personality Inventory | |
dc.subject | Polymorphism, Genetic | |
dc.subject | Psychiatric Status Rating Scales | |
dc.subject | Severity of Illness Index | |
dc.subject | South Africa | |
dc.title | Hoarding in obsessive-compulsive disorder: Clinical and genetic correlates | |
dc.type | Article |