Hoarding in obsessive-compulsive disorder: Clinical and genetic correlates

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dc.contributor.authorLochner C.
dc.contributor.authorKinnear C.J.
dc.contributor.authorHemmings, Sian M. J.en_ZA
dc.contributor.authorSeller C.
dc.contributor.authorNiehaus D.J.H.
dc.contributor.authorKnowles J.A.
dc.contributor.authorDaniels W.
dc.contributor.authorMoolman-Smook J.C.
dc.contributor.authorSeedat S.
dc.contributor.authorStein D.J.
dc.date.accessioned2011-05-15T16:01:56Z
dc.date.available2011-05-15T16:01:56Z
dc.date.issued2005
dc.description.abstractObjective: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation. Method: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004. Results: OCD patients with hoarding made up 18.1% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls. Conclusions: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here.
dc.description.versionArticle
dc.identifier.citationJournal of Clinical Psychiatry
dc.identifier.citation66
dc.identifier.citation9
dc.identifier.issn1606689
dc.identifier.urihttp://hdl.handle.net/10019.1/12227
dc.subjectDNA
dc.subjectadult
dc.subjectAfrica
dc.subjectarticle
dc.subjectCaucasian
dc.subjectclinical feature
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgenetic analysis
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjecthuman
dc.subjectinterview
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectObsessive-compulsive disorderen_ZA
dc.subjectpriority journal
dc.subjectscoring system
dc.subjectvenous blood
dc.subjectAdult
dc.subjectCatechol O-Methyltransferase
dc.subjectChild
dc.subjectChild Abuse
dc.subjectComorbidity
dc.subjectDiagnostic and Statistical Manual of Mental Disorders
dc.subjectDisability Evaluation
dc.subjectEthnic Groups
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectMental Disorders
dc.subjectObsessive-Compulsive Disorder
dc.subjectPersonality Inventory
dc.subjectPolymorphism, Genetic
dc.subjectPsychiatric Status Rating Scales
dc.subjectSeverity of Illness Index
dc.subjectSouth Africa
dc.titleHoarding in obsessive-compulsive disorder: Clinical and genetic correlates
dc.typeArticle
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