Amisulpride as adjunct to clozapine in treatment-resistant schizophrenia and schizoaffective disorder: An open-label pilot study

Simple item page
dc.contributor.authorKoen L.
dc.contributor.authorNiehaus D.J.
dc.contributor.authorSchulte A.
dc.contributor.authorMuller J.
dc.contributor.authorEmsley R.
dc.contributor.authorOosthulzen P.
dc.date.accessioned2011-05-15T15:57:46Z
dc.date.available2011-05-15T15:57:46Z
dc.date.issued2006
dc.description.abstractBackground. Although clozapine is the treatment of choice for treatment-resistant schizophrenia, many patients remain symptomatic despite adequate treatment with this medication. One suggested strategy to improve efficacy has been the addition of a potent D2 blocker such as amisulpride to treatment with clozapine. Methods. In this study, 20 subjects who were treatment-resistant to conventional antipsychotics and who were still symptomatic despite adequate treatment with clozapine received amisulpride as adjunctive treatment. After baseline assessment all subjects were titrated to amisulpride 400 mg per day and then reassessed after 8 weeks by a blinded rater. Results. Analysis showed statistically significant improvements in PANSS (Positive and Negative Symptom Scale) total score (t = 3.49, df = 18, p = 0.003), PANSS negative subscale score (t = 3.22, df = 18, p = 0.005), and PANSS depression factor score (t = 3.89, df = 19, p = 0.001). Discussion. This study suggests that addition of the second-generation antipsychotic amisulpride to a stable treatment regimen with clozapine may offer additional benefits in terms of negative and depressive symptoms.
dc.description.versionArticle
dc.identifier.citationSouth African Journal of Psychiatry
dc.identifier.citation12
dc.identifier.citation1
dc.identifier.issn16089685
dc.identifier.urihttp://hdl.handle.net/10019.1/10589
dc.subjectamisulpride
dc.subjectclozapine
dc.subjecthaloperidol
dc.subjectlithium carbonate
dc.subjectphenytoin
dc.subjectvalproic acid
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdose response
dc.subjectdrug efficacy
dc.subjectdrug potentiation
dc.subjectextrapyramidal symptom
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectpilot study
dc.subjectrandomized controlled trial
dc.subjectrating scale
dc.subjectschizoaffective psychosis
dc.subjectschizophrenia
dc.subjectscoring system
dc.subjectstatistical significance
dc.subjectsymptomatology
dc.titleAmisulpride as adjunct to clozapine in treatment-resistant schizophrenia and schizoaffective disorder: An open-label pilot study
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications