BDI-modelling of complex intracellular dynamics

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dc.contributor.authorJonker C.M.
dc.contributor.authorSnoep J.L.
dc.contributor.authorTreur J.
dc.contributor.authorWesterhoff H.V.
dc.contributor.authorWijngaards W.C.A.
dc.date.accessioned2011-05-15T15:59:50Z
dc.date.available2011-05-15T15:59:50Z
dc.date.issued2008
dc.description.abstractA BDI-based continuous-time modelling approach for intracellular dynamics is presented. It is shown how temporalised BDI-models make it possible to model intracellular biochemical processes as decision processes. By abstracting from some of the details of the biochemical pathways, the model achieves understanding in nearly intuitive terms, without losing veracity: classical intentional state properties such as beliefs, desires and intentions are founded in reality through precise biochemical relations. In an extensive example, the complex regulation of Escherichia coli vis-à-vis lactose, glucose and oxygen is simulated as a discrete-state, continuous-time temporal decision manager. Thus a bridge is introduced between two different scientific areas: the area of BDI-modelling and the area of intracellular dynamics. © 2007 Elsevier Ltd. All rights reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Theoretical Biology
dc.identifier.citation251
dc.identifier.citation1
dc.identifier.issn225193
dc.identifier.other10.1016/j.jtbi.2007.10.017
dc.identifier.urihttp://hdl.handle.net/10019.1/11387
dc.subjectglucose
dc.subjectlactose
dc.subjectoxygen
dc.subjectbacterium
dc.subjectbiochemistry
dc.subjectcatabolism
dc.subjectdecision making
dc.subjectmicrobial activity
dc.subjectmodeling
dc.subjectalgorithm
dc.subjectarticle
dc.subjectbehavioral science
dc.subjectcytology
dc.subjectdecision making
dc.subjectEscherichia coli
dc.subjectpriority journal
dc.subjectscientific literature
dc.subjectsimulation
dc.subjectAnimals
dc.subjectComputer Simulation
dc.subjectEscherichia coli
dc.subjectGlucose
dc.subjectIntracellular Space
dc.subjectLactose
dc.subjectModels, Biological
dc.subjectModels, Chemical
dc.subjectOxygen
dc.subjectSystems Biology
dc.subjectBacteria (microorganisms)
dc.subjectEscherichia coli
dc.titleBDI-modelling of complex intracellular dynamics
dc.typeArticle
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