A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents

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dc.contributor.authorNgara, Bernarden_ZA
dc.contributor.authorZvada, Simbarasheen_ZA
dc.contributor.authorChawana, Tariro Dianahen_ZA
dc.contributor.authorStray-Pedersen, Babillen_ZA
dc.contributor.authorNhachi, Charles Fungai Brianen_ZA
dc.contributor.authorRusakaniko, Simbarasheen_ZA
dc.date.accessioned2020-09-07T09:04:02Z
dc.date.available2020-09-07T09:04:02Z
dc.date.issued2020-08-03
dc.date.updated2020-08-09T03:19:59Z
dc.descriptionCITATION:Ngara, B., et al. 2020. A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents. BMC Pharmacology and Toxicology, 21:58, doi:10.1186/s40360-020-00437-y.
dc.descriptionThe original publication is available at https://bmcpharmacoltoxicol.biomedcentral.com
dc.description.abstractBackground: Adolescents experience higher levels of non-adherence to HIV treatment. Drug concentration in hair promises to be reliable for assessing exposure to antiretroviral (ARV) drugs. Pharmacokinetic modelling can explore utility of drug in hair. We aimed at developing and validating a pharmacokinetic model based on atazanavir/ ritonavir (ATV/r) in hair and identify factors associated with variabilities in hair accumulation. Methods: We based the study on secondary data analysis whereby data from a previous study on Zimbabwean adolescents which collected hair samples at enrolment and 3 months follow-up was used in model development. We performed model development in NONMEM (version 7.3) ADVAN 13. Results: There is 16% / 18% of the respective ATV/r in hair as a ratio of steady-state trough plasma concentrations. At follow-up, we estimated an increase of 30% /42% of respective ATV/r in hair. We associated a unit increase in adherence score with 2% increase in hair concentration both ATV/r. Thinner participants had 54% higher while overweight had 21% lower atazanavir in hair compared to normal weight participants. Adolescents receiving care from fellow siblings had atazanavir in hair at least 54% less compared to other forms of care. Conclusion: The determinants of increased ATV/r concentrations in hair found in our analysis are monitoring at follow up event, body mass index, and caregiver status. Measuring drug concentration in hair is feasibly accomplished and could be more accurate for monitoring ARV drugs exposure.
dc.description.urihttps://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-00437-y
dc.description.versionPublisher's version
dc.format.extent9 pagesen_ZA
dc.identifier.citationNgara, B., et al. 2020. A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents. BMC Pharmacology and Toxicology, 21:58, doi:10.1186/s40360-020-00437-y
dc.identifier.issn2050-6511 (online)
dc.identifier.otherdoi:10.1186/s40360-020-00437-y
dc.identifier.urihttp://hdl.handle.net/10019.1/108799
dc.language.isoen_ZAen_ZA
dc.publisherBMCen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectPharmacokinetics -- Modellingen_ZA
dc.subjectHIV-positive youth -- Zimbabween_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.titleA population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescentsen_ZA
dc.typeArticleen_ZA
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