A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents
Date
2020-08-03
Journal Title
Journal ISSN
Volume Title
Publisher
BMC
Abstract
Background: Adolescents experience higher levels of non-adherence to HIV treatment. Drug concentration in hair
promises to be reliable for assessing exposure to antiretroviral (ARV) drugs. Pharmacokinetic modelling can explore
utility of drug in hair. We aimed at developing and validating a pharmacokinetic model based on atazanavir/
ritonavir (ATV/r) in hair and identify factors associated with variabilities in hair accumulation.
Methods: We based the study on secondary data analysis whereby data from a previous study on Zimbabwean
adolescents which collected hair samples at enrolment and 3 months follow-up was used in model development.
We performed model development in NONMEM (version 7.3) ADVAN 13.
Results: There is 16% / 18% of the respective ATV/r in hair as a ratio of steady-state trough plasma concentrations.
At follow-up, we estimated an increase of 30% /42% of respective ATV/r in hair. We associated a unit increase in
adherence score with 2% increase in hair concentration both ATV/r. Thinner participants had 54% higher while
overweight had 21% lower atazanavir in hair compared to normal weight participants. Adolescents receiving care
from fellow siblings had atazanavir in hair at least 54% less compared to other forms of care.
Conclusion: The determinants of increased ATV/r concentrations in hair found in our analysis are monitoring at
follow up event, body mass index, and caregiver status. Measuring drug concentration in hair is feasibly
accomplished and could be more accurate for monitoring ARV drugs exposure.
Description
CITATION:Ngara, B., et al. 2020. A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents. BMC Pharmacology and Toxicology, 21:58, doi:10.1186/s40360-020-00437-y.
The original publication is available at https://bmcpharmacoltoxicol.biomedcentral.com
The original publication is available at https://bmcpharmacoltoxicol.biomedcentral.com
Keywords
Pharmacokinetics -- Modelling, HIV-positive youth -- Zimbabwe, Antiretroviral agents
Citation
Ngara, B., et al. 2020. A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents. BMC Pharmacology and Toxicology, 21:58, doi:10.1186/s40360-020-00437-y