The efficacy and safety of complete pericardial drainage by means of intrapericardial fibrinolysis for the prevention of complications of pericardial effusion : a systematic review protocol
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
BMJ Publishing Group
Abstract
ENGLISH SUMMARY : Introduction:
Intrapericardial fibrinolysis has been
proposed as a means of preventing complications of pericardial effusion such as cardiac tamponade,
persistent and recurrent pericardial effusion, and pericardial constriction. There is a need to understand
the efficacy and safety of this procedure because it shows promise.
Methods and analysis: We aim to assess the effects of intrapericardial fibrinolysis in the treatment of
pericardial effusion. We will search PubMed, the Cochrane Library, African Journals online, Cumulative
Index to Nursing and Allied Health Literature, Trip database, Clinical trials.gov and the WHO International
Clinical Trials Registry Platform for studies that evaluate the efficacy and/or safety of complete
pericardial fluid drainage by intrapericardial fibrinolysis irrespective of study design, geographical location, language, age of participants, aetiology of pericarditis or types of fibrinolytics. Two authors will do the search independently, screen the search outputs for potentially
eligible studies and assess whether the studies meet the inclusion criteria. Discrepancies between the two
authors will be resolved through discussion and arbitration by a third author. Data from the selected
studies shall be extracted using a standardised data collection form which will be piloted before use. The
methodological quality of studies will be assessed using the Cochrane Collaboration’s tools for assessing
risk of bias for experimental studies and non-randomised studies, respectively. The primary meta-
analysis will use random effects models due to expected interstudy heterogeneity. Dichotomous data
will be analysed using relative risk and continuous with data mean differences, both with 95% CIs.
Description
CITATION: Kakia, A., et al. 2016. The efficacy and safety of complete pericardial drainage by means of intrapericardial fibrinolysis for the prevention of complications of pericardial effusion : a systematic review protocol. BMJ Open, 6:e007842,
doi:10.1136/bmjopen-2015-007842.
The original publication is available at http://bmjopen.bmj.com
The original publication is available at http://bmjopen.bmj.com
Keywords
Pericardium -- Paracentesis, Injections, Intraperitoneal, Intrapericardial fibrinolysis, Systematic reviews (Medical research)
Citation
Kakia, A., et al. 2016. The efficacy and safety of complete pericardial drainage by means of intrapericardial fibrinolysis for the prevention of complications of pericardial effusion : a systematic review protocol. BMJ Open, 6:e007842,
doi:10.1136/bmjopen-2015-007842