NMR spectroscopy as basis for characterization of pluronic® F108 and its derivatives

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dc.contributor.authorYanic C.
dc.contributor.authorBredenkamp M.W.
dc.contributor.authorJacobs E.P.
dc.contributor.authorSpies H.S.C.
dc.contributor.authorSwart P.
dc.date.accessioned2011-05-15T15:59:27Z
dc.date.available2011-05-15T15:59:27Z
dc.date.issued2000
dc.description.abstractThe hydroxyl end groups of Pluronic®F108 {a triblock copolymer surfactant of poly(ethylene glycol) and poly(propylene glycol) [PEG-PPG-PEG]) were modified into primary amine, sulfonic acid, and quaternary ammonium equivalents for use in affinity chromatography. NMR was used for monitoring the efficacy of modifications on intermediaries and final products. The primary amine equivalents were prepared via conversion of the hydroxyl groups to a tosylate, its displacement with an azide, followed by reduction to the primary amine. The sulfonic acid equivalents were prepared via hydroxyl group tosylation, the displacement of tosylate with thiol, and its oxidation to sulfonic acid. The conversion to trimethyl ammonium was achieved via hydroxyl group tosylation, tosylate displacement by halide, and halide displacement with trimethylamine. © 2000 John Wiley & Sons, Inc.
dc.description.versionArticle
dc.identifier.citationJournal of Applied Polymer Science
dc.identifier.citation78
dc.identifier.citation1
dc.identifier.issn218995
dc.identifier.urihttp://hdl.handle.net/10019.1/11189
dc.subjectAffinity chromatography
dc.subjectAmines
dc.subjectAmmonium compounds
dc.subjectChemical modification
dc.subjectDerivatives
dc.subjectMass spectrometry
dc.subjectNuclear magnetic resonance spectroscopy
dc.subjectOrganic acids
dc.subjectOxidation
dc.subjectPolyethylene glycols
dc.subjectSurface active agents
dc.subjectGlycol triblock copolymer
dc.subjectHydroxyl group tosylation
dc.subjectPolypropylene glycol
dc.subjectSulfonic acid
dc.subjectTosylate
dc.subjectTrimethylamine
dc.subjectBlock copolymers
dc.titleNMR spectroscopy as basis for characterization of pluronic® F108 and its derivatives
dc.typeArticle
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