Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder

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dc.contributor.authorDelucchi K.L.
dc.contributor.authorKaterberg H.
dc.contributor.authorStewart S.E.
dc.contributor.authorDenys D.A.J.P.
dc.contributor.authorLochner C.
dc.contributor.authorStack D.E.
dc.contributor.authorDen Boer J.A.
dc.contributor.authorVan Balkom A.J.L.M.
dc.contributor.authorJenike M.A.
dc.contributor.authorStein D.J.
dc.contributor.authorCath D.C.
dc.contributor.authorMathews C.A.
dc.date.accessioned2011-05-25T08:49:50Z
dc.date.available2011-05-25T08:49:50Z
dc.date.issued2011
dc.description.abstractObjective: Obsessive-compulsive disorder (OCD) is phenomenologically heterogeneous, and findings of underlying structure classification based on symptom grouping have been ambiguous to date. Variable-centered approaches, primarily factor analysis, have been used to identify homogeneous groups of symptoms; but person-centered latent methods have seen little use. This study was designed to uncover sets of homogeneous groupings within 1611 individuals with OCD based on symptoms. Method: Latent class analysis models using 61 obsessive-compulsive symptoms collected from the Yale-Brown Obsessive-Compulsive Scale were fit. Relationships between latent class membership and treatment response, sex, symptom severity, and comorbid tic disorders were tested for relationship to class membership. Results: Latent class analysis models of best fit yielded 3 classes. Classes differed only in frequency of symptom endorsement. Classes with higher symptom endorsement were associated with earlier age of onset, being male, higher Yale-Brown Obsessive-Compulsive Scale symptom severity scores, and comorbid tic disorders. There were no differences in treatment response between classes. Conclusions: These results provide support for the validity of a single underlying latent OCD construct, in addition to the distinct symptom factors identified previously via factor analyses. © 2011 Elsevier Inc. All rights reserved.
dc.description.versionArticle
dc.identifier.citationComprehensive Psychiatry
dc.identifier.citation52
dc.identifier.citation3
dc.identifier.citation334
dc.identifier.citation341
dc.identifier.issn0010440X
dc.identifier.other10.1016/j.comppsych.2010.06.007
dc.identifier.urihttp://hdl.handle.net/10019.1/14712
dc.titleLatent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder
dc.typeArticle
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