Membrane saturated fatty acids and disease progression in Multiple Sclerosis patients

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dc.contributor.authorHon, G. M.
dc.contributor.authorHassan, M. S.
dc.contributor.authorVan Rensburg, S. J.
dc.contributor.authorAbel, S.
dc.contributor.authorErasmus R. T.
dc.contributor.authorMatsha, T.
dc.date.accessioned2011-05-15T15:59:58Z
dc.date.available2011-05-15T15:59:58Z
dc.date.issued2009
dc.description.abstractThe risk of developing multiple sclerosis is associated with increased dietary intake of saturated fatty acids. We determined the fatty acid composition within the different phospholipid fractions of red blood and peripheral blood mononuclear cell membranes of 31 patients diagnosed with multiple sclerosis and 30 healthy control subjects using gas chromatography. Individual saturated fatty acids were correlated with the severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale. Significant increases were found in multiple sclerosis peripheral blood mononuclear cell membrane sphingomyelin C14:0 and phosphatidylinositol C22:0. In the peripheral blood mononuclear cell membranes, C22:0 and C24:0 showed positive correlations, while C14:0, C16:0 and C20:0 showed inverse correlations with the Functional System Scores. In conclusion, this study is in accordance with previous studies that have shown an increase in shorter long-chain SATS in MS patients. In addition, this study also showed that higher C14:0 and C16:0 reflected better disease outcome as demonstrated by the inverse correlation with the EDSS and FSS. We have also characterized the specific SATS, that is, long-chain SATS that may increase the risk of developing MS. © 2009 Springer Science+Business Media, LLC.
dc.description.versionArticle
dc.identifier.citationMetabolic Brain Disease
dc.identifier.citation24
dc.identifier.citation4
dc.identifier.issn8857490
dc.identifier.other10.1007/s11011-009-9159-0
dc.identifier.urihttp://hdl.handle.net/10019.1/11457
dc.subjectC reactive protein
dc.subjectsaturated fatty acid
dc.subjectadult
dc.subjectarticle
dc.subjectblood sampling
dc.subjectcell membrane
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdietary intake
dc.subjectdisease course
dc.subjectdisease severity
dc.subjecterythrocyte membrane
dc.subjectExpanded Disability Status Scale
dc.subjectfat intake
dc.subjectfemale
dc.subjectgas chromatography
dc.subjecthuman
dc.subjectlipid composition
dc.subjectmale
dc.subjectmultiple sclerosis
dc.subjectperipheral blood mononuclear cell
dc.subjectAdult
dc.subjectBiological Markers
dc.subjectCausality
dc.subjectDietary Fats
dc.subjectDisability Evaluation
dc.subjectDisease Progression
dc.subjectErythrocytes
dc.subjectFatty Acids
dc.subjectFemale
dc.subjectHumans
dc.subjectLeukocytes, Mononuclear
dc.subjectMale
dc.subjectMembrane Lipids
dc.subjectMiddle Aged
dc.subjectMolecular Weight
dc.subjectMultiple Sclerosis
dc.subjectPhosphatidylinositols
dc.subjectSphingomyelins
dc.titleMembrane saturated fatty acids and disease progression in Multiple Sclerosis patients
dc.typeArticle
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