• Assessment of Epstein-Barr virus in blood from patients with multiple sclerosis 

  Hon G.M.; Hassan M.S.; Rensburg S.J.V.; Erasmus R.T.; Matsha T.E. (2012)

  Viruses such as Epstein-Barr virus (EBV) which can establish latent infections in the central nervous system or the immune system have been associated with chronic neurological disorders, including multiple sclerosis. ...
• A diffusion tensor imaging and neuropsychological study of prospective memory impairment in South African HIV positive individuals 

  Jacqueline H.; Jenny W.-T.; Jean-Paul F.; Bruce S.; Robert P.; Kevin T.; Dan S.; John J. (2012)

  HIV-associated prospective memory (ProM) impairment has emerged, in earlier studies as a significant predictor of medication management and independence in activities of daily living. The relationship between ProM and white ...
• Rates and predictors of failure of first-line antiretroviral therapy and switch to second-line ART in South Africa 

  Fox M.P.; Cutsem G.V.; Giddy J.; Maskew M.; Keiser O.; Prozesky H.; Wood R.; Hernan M.A.; Sterne J.A.C.; Egger M.; Boulle A. (2012)

  Objectives: To measure rates and predictors of virologic failure and switch to second-line antiretroviral therapy (ART) in South Africa. Design: Observational cohort study. Methods: We included ART-naive adult patients ...
• Changes in pediatric HIV-related hospital admissions and mortality in Soweto, South Africa, 1996-2011: Light at the end of the tunnel? 

  Meyers T.; Dramowski A.; Schneider H.; Gardiner N.; Kuhn L.; Moore D. (2012)

  Background: With widespread availability of pediatric antiretroviral therapy and improved access to prevention of mother-to-child transmission (PMTCT), it is important to monitor the impact on pediatric HIV-related hospital ...
• Methamphetamine use by pregnant women: Impact on the neonate and challenges for the perinatal team 

  Madide A.; Smith J.; Odendaal H. (2012)

  [No abstract available]
• Recommendations for the treatment of hypertension in the elderly and very elderly - A scotoma within international guidelines 

  Schafer H.-H.; De Villiers J.N.; Sudano I.; Dischinger S.; Theus G.-R.; Zilla P.; Dieterle T. (2012)

  The recommendations of international scientific societies for the treatment of hypertension in the geriatric population are different. Lack of outcome trials, non-standardised terminology as well as differing levels of ...
• Dopamine transporter binding in social anxiety disorder: The effect of treatment with escitalopram 

  Warwick, James M.; Carey P.D.; Cassimjee N.; Lochner C.; Hemmings, Sian M. J.; Moolman-Smook H.; Beetge E.; Dupont P.; Stein D.J. (2012)

  Social anxiety disorder (SAD) is characterised by fear of social or performance situations where the individual is exposed to unfamiliar people or to possible scrutiny by others. The literature on dopamine ligands and ...
• Pharmacokinetics in stable kidney transplant recipients after conversion from twice-daily to once-daily tacrolimus formulations 

  Van Hooff J.; Van Der Walt I.; Kallmeyer J.; Miller D.; Dawood S.; Moosa M.R.; Christiaans M.; Karpf C.; Undre N. (2012)

  Background: A prolonged-release formulation of tacrolimus for once-daily administration (Tacrolimus QD) has been developed to offer potential improvements in patient adherence. This study compared the pharmacokinetics (PK) ...
• An evaluation of the Shandon Papspin liquid-based oral test using a novel cytologic scoring system 

  Afrogheh A.; Wright C.A.; Sellars S.L.; Wetter J.; Pelser A.; Schubert P.T.; Hille J. (2012)

  Objectives. The aim of this study was to evaluate a cost-effective oral liquid-based cytology screening test, Shandon Papspin (PS). Study Design. We compared the diagnostic accuracy of PS with surgical biopsy in 69 patients. ...
• Early diagnosis of in utero and intrapartum HIV infection in infants prior to 6 weeks of age 

  Lilian R.R.; Kalk E.; Bhowan K.; Berrie L.; Carmona S.; Technau K.; Sherman G.G. (2012)

  Early initiation of antiretroviral therapy reduces HIV-related infant mortality. The early peak of pediatric HIV-related deaths in South Africa occurs at 3 months of age, coinciding with the earliest age at which treatment ...
• Three postpartum antiretroviral regimens to prevent intrapartum HIV infection 

  Nielsen-Saines K.; Watts D.H.; Veloso V.G.; Bryson Y.J.; Joao E.C.; Pilotto J.H.; Gray G.; Theron G.; Santos B.; Fonseca R.; Kreitchmann R.; Pinto J.; Mussi-Pinhata M.M.; Ceriotto M.; Machado D.; Bethel J.; Morgado M.G.; Dickover R.; Camarca M.; Mirochnick M.; Siberry G.; Grinsztejn B.; Moreira R.I.; Bastos F.I.; Xu J.; Moye J.; Mofenson L.M. (2012)

  BACKGROUND: The safety and efficacy of adding antiretroviral drugs to standard zidovudine prophylaxis in infants of mothers with human immunodeficiency virus (HIV) infection who did not receive antenatal antiretroviral ...
• Is metformin indicated as primary ovulation induction agent in women with PCOS? A systematic review and meta-analysis 

  Siebert T.I.; Viola M.I.; Steyn D.W.; Kruger T.F. (2012)

  Background: A recent meta-analysis has proven that metformin (M) is highly effective for ovulation induction in the clomiphene citrate (CC)-resistant patient. There is uncertainty whether M should be introduced as a primary ...
• 7-year follow up of intra-operative radiotherapy for early breast cancer in a developing country 

  Baatjes K.J.; Apffelstaedt J.P. (2012)

  Scarce radiation resources and an often poor, rural population make single fraction, definitive intra-operative radiation (IORT) ideal for developing countries. From 2002 to 2005 IORT in breast conservation was administered ...
• Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents 

  Diacon A.H.; Maritz J.S.; Venter A.; Van Helden P.D.; Dawson R.; Donald P.R. (2012)

  The measurement of early bactericidal activity (EBA) is the first step in the clinical investigation of antituberculosis agents. EBA is determined by quantifying the viable sputum mycobacterial load on consecutive days of ...
• Letter: The effects of overlapping symptoms on the response to PPI therapy in GERD - Authors' reply 

  Monnikes H.; Schwan T.; Van Rensburg C.; Straszak A.; Theek C.; Sander P.; Luhmann R. (2012)

  [No abstract available]
• Discordant drug susceptibility for mycobacterium tuberculosis within families 

  Seddon J.A.; Jordaan A.M.; Victor T.C.; Schaaf H.S. (2012)

  Children with presumed tuberculosis who are in contact with a multidrug-resistant source case should be treated according to the drug susceptibility of the source case's isolate. However, it is important to obtain a ...
• The role of second-generation 5-HT 3 receptor antagonists in managing chemotherapy-induced nausea and vomiting in hematological malignancies 

  Schwartzberg L.S.; Jacobs P.; Matsouka P.; Azevedo W.; Pinto A. (2012)

  Compared with solid tumor patients, those with hematological malignancies are at particular risk of chemotherapy-induced nausea and vomiting (CINV) because of their young age, exposure to highly-emetogenic induction, ...
• Accurate sperm morphology assessment predicts sperm function 

  Abu Hassan, Abu D.; Franken, D. R.; Hoffman, B.; Henkel, R. (2012)

  Sperm morphology has been associated with in vitro as well as in vivo fertilisation. The study aimed to evaluate the possible relation between the percentage of spermatozoa with normal morphology and the following sperm ...
• Completion of and early response to chemoradiation among human immunodeficiency virus (HIV)-positive and HIV-negative patients with locally advanced cervical carcinoma in South Africa 

  Simonds H.M.; Wright J.D.; Du Toit N.; Neugut A.I.; Jacobson J.S. (2012)

  BACKGROUND: Very few published studies have dealt with the management of locally advanced cervix carcinoma among human immunodeficiency virus (HIV)-positive patients. The objective of this study was to compare the clinical ...
• Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: A pilot study 

  Henkel R.; Fransman W.; Hipler U.-C.; Wiegand C.; Schreiber G.; Menkveld R.; Weitz F.; Fisher D. (2012)

  The biodiversity in South Africa provides more than 30000 higher plants, of which more than 3000 are used by traditional healers to treat diseases. Typha capensis (bulrush) is one of the medicinal plants used in South ...

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