Prostaglandin effects in the neuroendocrine mammalian brain

Macfarlane C. M.
Taljaard J. J. F.
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Various prostaglandins (PGs) have been found in several areas of the brain. PGs of the E series have been found in the pituitary and pineal glands and the median eminence, and they have been shown to influence hypothalamic endocrine-release characteristics and release of melatonin from the pineal gland. It has been suggested that they may act, along with membrane phospholipids, as a link between neuronal depolarization, calcium uptake and neurotransmitter release. They may also influence postsynaptic effects of neurotransmitters. These latter effects may be due to interaction with membrane phospholipid- and cyclic nucleotide-induced changes of specific protein kinases. The PGs may act as intracellular mediators of neuro-endocrine control.
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Calcium absorption, Prostaglandin, Prostaglandin d2, Prostaglandin e2, Prostaglandin f2 alpha, Prostaglandin g2, Prostaglandin h2, Protein kinase, Central nervous system, Endocrine system, Hypothalamus, Neuroendocrinology, Endocrine Glands, Membrane Lipids, Neurons, Neurosecretory systems, Neurotransmitters, Norepinephrine, Phospholipids, Pineal Gland, Pituitary Hormones, Rats as laboratory animals, Synaptic transmission, Tissue distribution, Endocrine gland metabolism, Neuro-endocrine control, Hypothalamic output and secretion, Interneuron interaction
Macfarlane, C.M., Taljaard, J.J.M. 1985. Prostaglandin effects in the neuroendocrine mammalian brain. South African Medical Journal, vol. 67, March 30. pp. 503-506