D8/17 in obsessive-compulsive disorder and trichotillomania

Niehaus, D. J. H. ; Knowles, J. A. ; Van Kradenberg, J. ; Du Toit, W. D. ; Kaminer, D. ; Seedat, S. ; Daniels, W. ; Cotton, M. ; Brink, P. ; Beyers, A. D. ; Bouic, P. ; Chapman, F. ; Zabriskie, J. B. ; Stein, D. J. (1999)

CITATION: Niehaus, D. J. H. et al. 1999. D8/17 in obsessive-compulsive disorder and trichotillomania. South African Medical Journal, 89(7):755-756.

The original publication is available at http://www.samj.org.za


The finding that patients with Sydenham's chorea often demonstrate obsessive-compulsive disorder (OeD) has fostered increased interest in possible neuroimmunological mechanisms in OCD.' Increased expression of the B-Iymphocyte antigen 08/17, which has been hypothesised to be a genetically inherited trait marker for susceptibility to rheumatic fever, has recently been demonstrated to be higher in OCD patients than in normal controls.2.3 To date, however, 08/17 expression has been studied in few psychiatric control populations.

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