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An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens : study protocol for a randomized controlled trial
(BioMed Central, 2017-11-25)Background: Current guidelines for treatment of multidrug-resistant tuberculosis (MDR-TB) are largely based on expert opinion and observational data. Fluoroquinolones remain an essential part of MDR-TB treatment, but ... -
Enhanced oxidative stress and other potential biomarkers for retinopathy in type 2 diabetics : beneficial effects of the nutraceutic supplements
(Hindawi, 2015)We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation ... -
Perceived barriers for accessing health services among individuals with disability in four African countries
(Public Library of Science, 2015)ENGLISH ABSTRACT: There is an increasing awareness among researchers and others that marginalized and vulnerable groups face problems in accessing health care. Access problems in particular in low-income countries may ... -
Oral v. pulse intravenous cyclophosphamide : a retrospective analysis of adverse events in a setting with a high burden of infectious disease
(Health & Medical Publishing Group, 2015)Background. Cyclophosphamide (CPM) is still considered to be the first-line treatment for many life-threatening autoimmune conditions. It does, however, carry a significant risk of serious adverse events, especially ... -
Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome type 1
(PLoS, 2014-04-04)The study assesses complexity of the cardiac control directed to the sinus node and to ventricles in long QT syndrome type 1 (LQT1) patients with KCNQ1-A341V mutation. Complexity was assessed via refined multiscale entropy ... -
Oral versus pulse intravenous cyclophosphamide: a retrospective analysis of adverse events in a high infectious diseases burdened setting
(Stellenbosch : Stellenbosch University, 2014-01-14)ENGLISH ABSTRACT: Background Cyclophosphamide (CPM) is still considered to be the first line treatment of many life-threatening autoimmune conditions. It does however carry significant risk for severe adverse events ... -
Challenges in biobank governance in Sub-Saharan Africa
(BioMed Central, 2013-09)Background: Biological sample and data transfer within and out of Africa is steeped in controversy With the H3Africa project now aiming to establish biobanks in Africa, it is essential that there are ethical and ... -
Discourse of final-year medical students during clinical case presentations
(Health and Medical Publishing Group (HMPG), 2011-06)Introduction: The need for medical students to adopt a discourse appropriate to the field is repeatedly emphasised by teaching staff during lectures and ward rounds. The acquisition of such discourse is often not assessed, ... -
Advancing research ethics training in Southern Africa (ARESA)
(Health and Medical Publishing Group (HMPG), 2012-12)Southern Africa is a research-rich environment in which research ethics review is critical. The research ethics review system is well established but considerable variability in capacity and training exists among the various ... -
Patients as consumers of health care in South Africa : the ethical and legal implications
(BioMed Central, 2013-03)Background South Africa currently has a pluralistic health care system with separate public and private sectors. It is, however, moving towards a socialised model with the introduction of National Health Insurance. The ... -
An investigation of two animal models of anxiety : central administration of corticotropin-releasing factor on the behaviour and neurochemistry of rats, and the effect of pharmacotherapy on spontaneous stereotypical behaviour and NMDA receptor function in mice
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: Corticotropin-releasing factor (CRF) study Background: Hypothalamic pituitary adrenal (HPA)-axis dysfunction is a common symptom of patients with anxiety disorders like posttraumatic stress disorder ... -
Comparative analysis of familial hypercholestrerolaemia in different populations
(Stellenbosch : Stellenbosch University, 1999-12)ENGLISH SUMMARY: Familial hypercholesterolaemia (FH) and familial defective apolipoprotein B-IOO (FDB) are relatively common disorders of lipid and lipoprotein metabolism caused by mutations in the low density lipoprotein ... -
HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis : a prospective observational study
(Public Library of Science (PLOS), 2008-04)Background: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotheraphy. The impact of human immunodeficiency ... -
Estimating the resources needed and savings anticipated from roll-out of adult male circumcision in sub-Saharan Africa
(Public Library of Science (PLOS), 2008-08)Background: Trials in Africa indicate that medical adult male circumcision (MAMC) reduces the risk of HIV by 60%. MAMC may avert 2 to 8 million HIV infections over 20 years in sub-Saharan Africa and cost less than treating ... -
Alcohol, aspirin, depression, smoking, stress and the patient with a gastric ulcer
(Health and Medical Publishing Group -- HMPG, 1976-02)It would seem that a gastric ulcer is the product of an interaction between chronic gastritis, the acid (and pepsin) of the gastric juice, and one or more precipitating factors. In a group of 194 consecutive patients with ... -
Allergic asthma in different population groups in the western Cape : causative and complicating factors
(Health and Medical Publishing Group -- HMPG, 1988-02)Allergic asthma is a disease with a well-defined aetiology, the recognition and elimination of which could be achieved with relatively simple and inexpensive prophylactic treatment. Some of the well-known factors - respiratory ... -
Amoebic lung abscesses : a case report
(Health and Medical Publishing Group -- HMPG, 1989-04)A case of multiple amoebic lung abscesses without indication of direct extension from a subclinical liver abscess, which delayed correct diagnosis, is reported. Severe constitutional symptoms, life-threatening haemoptysis ...
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