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Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics
(Nature Research, 2018-07-09)Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation ... -
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus
(Nature Research, 2018-11-14)Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically ... -
Teaching medical students in a new rural longitudinal clerkship : opportunities and constraints
(Levy Library Press, 2018)Background: Medical schools in Africa are responding to the call to increase numbers of medical graduates by up-scaling decentralized clinical training. One approach to decentralized clinical training is the longitudinal ... -
Introducing an e-learning solution for medical education in Liberia
(Levy Library Press, 2018)Background: The Ebola virus epidemic and civil war in Liberia left the country in need of strengthening the health workforce. E-learning in medical education provides relevant learning opportunities for students, develops ... -
An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens : study protocol for a randomized controlled trial
(BioMed Central, 2017-11-25)Background: Current guidelines for treatment of multidrug-resistant tuberculosis (MDR-TB) are largely based on expert opinion and observational data. Fluoroquinolones remain an essential part of MDR-TB treatment, but ... -
Enhanced oxidative stress and other potential biomarkers for retinopathy in type 2 diabetics : beneficial effects of the nutraceutic supplements
(Hindawi, 2015)We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation ... -
Perceived barriers for accessing health services among individuals with disability in four African countries
(Public Library of Science, 2015)ENGLISH ABSTRACT: There is an increasing awareness among researchers and others that marginalized and vulnerable groups face problems in accessing health care. Access problems in particular in low-income countries may ... -
Oral v. pulse intravenous cyclophosphamide : a retrospective analysis of adverse events in a setting with a high burden of infectious disease
(Health & Medical Publishing Group, 2015)Background. Cyclophosphamide (CPM) is still considered to be the first-line treatment for many life-threatening autoimmune conditions. It does, however, carry a significant risk of serious adverse events, especially ... -
Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome type 1
(PLoS, 2014-04-04)The study assesses complexity of the cardiac control directed to the sinus node and to ventricles in long QT syndrome type 1 (LQT1) patients with KCNQ1-A341V mutation. Complexity was assessed via refined multiscale entropy ... -
Oral versus pulse intravenous cyclophosphamide: a retrospective analysis of adverse events in a high infectious diseases burdened setting
(Stellenbosch : Stellenbosch University, 2014-01-14)ENGLISH ABSTRACT: Background Cyclophosphamide (CPM) is still considered to be the first line treatment of many life-threatening autoimmune conditions. It does however carry significant risk for severe adverse events ... -
Challenges in biobank governance in Sub-Saharan Africa
(BioMed Central, 2013-09)Background: Biological sample and data transfer within and out of Africa is steeped in controversy With the H3Africa project now aiming to establish biobanks in Africa, it is essential that there are ethical and ... -
Discourse of final-year medical students during clinical case presentations
(Health and Medical Publishing Group (HMPG), 2011-06)Introduction: The need for medical students to adopt a discourse appropriate to the field is repeatedly emphasised by teaching staff during lectures and ward rounds. The acquisition of such discourse is often not assessed, ... -
Advancing research ethics training in Southern Africa (ARESA)
(Health and Medical Publishing Group (HMPG), 2012-12)Southern Africa is a research-rich environment in which research ethics review is critical. The research ethics review system is well established but considerable variability in capacity and training exists among the various ... -
Patients as consumers of health care in South Africa : the ethical and legal implications
(BioMed Central, 2013-03)Background South Africa currently has a pluralistic health care system with separate public and private sectors. It is, however, moving towards a socialised model with the introduction of National Health Insurance. The ... -
An investigation of two animal models of anxiety : central administration of corticotropin-releasing factor on the behaviour and neurochemistry of rats, and the effect of pharmacotherapy on spontaneous stereotypical behaviour and NMDA receptor function in mice
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: Corticotropin-releasing factor (CRF) study Background: Hypothalamic pituitary adrenal (HPA)-axis dysfunction is a common symptom of patients with anxiety disorders like posttraumatic stress disorder ... -
Comparative analysis of familial hypercholestrerolaemia in different populations
(Stellenbosch : Stellenbosch University, 1999-12)ENGLISH SUMMARY: Familial hypercholesterolaemia (FH) and familial defective apolipoprotein B-IOO (FDB) are relatively common disorders of lipid and lipoprotein metabolism caused by mutations in the low density lipoprotein ... -
HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis : a prospective observational study
(Public Library of Science (PLOS), 2008-04)Background: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotheraphy. The impact of human immunodeficiency ... -
Estimating the resources needed and savings anticipated from roll-out of adult male circumcision in sub-Saharan Africa
(Public Library of Science (PLOS), 2008-08)Background: Trials in Africa indicate that medical adult male circumcision (MAMC) reduces the risk of HIV by 60%. MAMC may avert 2 to 8 million HIV infections over 20 years in sub-Saharan Africa and cost less than treating ... -
Post-discharge follow-up of stroke patients at Groote Schuur Hospital - a prospective study
(Health & Medical Publishing Group, 1994)A survey of 59 stroke patients was undertaken between 3 and 6 months after the event to determine whether a weekly stroke round would improve the rate of referral for rehabilitation. Comparison with a previous survey at ... -
Die Geneeskunde Opleidingskompleks, Parowvallei
(Health & Medical Publishing Group, 1975)The building complex erected for training in the area of medicine is described in relation to the thinking which forms the background for these physical facilities. Provision is made for training of students in medicine, ...
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