General Medicine
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Evaluation of factors and patterns influencing the 30-day readmission rate at a tertiary-level hospital in a resource-constrained setting in Cape Town, South Africa
(Health & Medical Publishing Group, 2019)Background. Factors contributing to and causes of hospital readmissions have been investigated worldwide, but very few studies have been performed in South Africa (SA) and none in the Western Cape Province. Objectives. ... -
The significance of non-occupational asbestos exposure in women with mesothelioma
(Wiley Open Access, 2019-01)ENGLISH ABSTRACT: Malignant mesothelioma is a rare and aggressive pleural or peritoneal tumour almost always caused by exposure to asbestos fibres. Exposure to asbestos can cause malignant mesothelioma 30–40 years after ... -
The prevalence and risk factors for diabetes mellitus in healthcare workers at Tygerberg hospital, Cape Town, South Africa : a retrospective study
(MedPharm Publications, 2019)Objectives: To assess the contribution of traditional and modifiable risk factors to the overall risk and prevalence of type 2 diabetes mellitus (T2DM) amongst health workers (HWs) in the public sector. Design: A ... -
The rise and fall of hydroxychloroquine for the treatment and prevention of COVID-19
(American Society of Tropical Medicine and Hygiene, 2021)ENGLISH ABSTRACT: The efficacy and safety of hydroxychloroquine (HCQ) for the prevention and treatment of COVID-19 has received great attention, and most notably, the enthusiasm for HCQ has been one of politicization ... -
Exploring the factors that affect new graduates’ transition from students to health professionals : a systematic integrative review protocol
(BMJ Publishing Group, 2020-05-15)Introduction: To become a competent health professional, the nature of new graduates’ transition plays a fundamental role. The systematic integrative review will aim to identify the existing literature pertaining to the ... -
Staff testing for COVID-19 via an online pre-registration form
(medRxiv, 2020)Background: Healthcare workers are at increased risk of contracting SARS-CoV-2 and potentially causing institutional outbreaks. Staff testing is critical in identifying and isolating infected individuals while also reducing ... -
High HIV prevalence in an early cohort of hospital admissions with COVID-19 in Cape Town, South Africa
(Health & Medical Publishing Group, 2020)Background. South Africa (SA) has a high prevalence of HIV and tuberculosis. Cape Town was the SA metropole most affected in the early stages of the COVID-19 pandemic. Early observational data from Africa may provide ... -
Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics
(Nature Research, 2018-07-09)Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation ... -
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus
(Nature Research, 2018-11-14)Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically ... -
Essential items for reporting of scaling studies of health interventions (SUCCEED) : protocol for a systematic review and Delphi process
(BMC (part of Springer Nature), 2020-01-11)Background: The lack of a reporting guideline for scaling of evidence-based practices (EBPs) studies has prompted the registration of the Standards for reporting studies assessing the impact of scaling strategies of EBPs ... -
Teaching medical students in a new rural longitudinal clerkship : opportunities and constraints
(Levy Library Press, 2018)Background: Medical schools in Africa are responding to the call to increase numbers of medical graduates by up-scaling decentralized clinical training. One approach to decentralized clinical training is the longitudinal ... -
Introducing an e-learning solution for medical education in Liberia
(Levy Library Press, 2018)Background: The Ebola virus epidemic and civil war in Liberia left the country in need of strengthening the health workforce. E-learning in medical education provides relevant learning opportunities for students, develops ... -
An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens : study protocol for a randomized controlled trial
(BioMed Central, 2017-11-25)Background: Current guidelines for treatment of multidrug-resistant tuberculosis (MDR-TB) are largely based on expert opinion and observational data. Fluoroquinolones remain an essential part of MDR-TB treatment, but ... -
Enhanced oxidative stress and other potential biomarkers for retinopathy in type 2 diabetics : beneficial effects of the nutraceutic supplements
(Hindawi, 2015)We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation ... -
Perceived barriers for accessing health services among individuals with disability in four African countries
(Public Library of Science, 2015)ENGLISH ABSTRACT: There is an increasing awareness among researchers and others that marginalized and vulnerable groups face problems in accessing health care. Access problems in particular in low-income countries may ... -
Oral v. pulse intravenous cyclophosphamide : a retrospective analysis of adverse events in a setting with a high burden of infectious disease
(Health & Medical Publishing Group, 2015)Background. Cyclophosphamide (CPM) is still considered to be the first-line treatment for many life-threatening autoimmune conditions. It does, however, carry a significant risk of serious adverse events, especially ... -
Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome type 1
(PLoS, 2014-04-04)The study assesses complexity of the cardiac control directed to the sinus node and to ventricles in long QT syndrome type 1 (LQT1) patients with KCNQ1-A341V mutation. Complexity was assessed via refined multiscale entropy ... -
Oral versus pulse intravenous cyclophosphamide: a retrospective analysis of adverse events in a high infectious diseases burdened setting
(Stellenbosch : Stellenbosch University, 2014-01-14)ENGLISH ABSTRACT: Background Cyclophosphamide (CPM) is still considered to be the first line treatment of many life-threatening autoimmune conditions. It does however carry significant risk for severe adverse events ... -
Challenges in biobank governance in Sub-Saharan Africa
(BioMed Central, 2013-09)Background: Biological sample and data transfer within and out of Africa is steeped in controversy With the H3Africa project now aiming to establish biobanks in Africa, it is essential that there are ethical and ... -
Discourse of final-year medical students during clinical case presentations
(Health and Medical Publishing Group (HMPG), 2011-06)Introduction: The need for medical students to adopt a discourse appropriate to the field is repeatedly emphasised by teaching staff during lectures and ward rounds. The acquisition of such discourse is often not assessed, ...
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