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Pulmonology
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Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection
(American Society for Clinical Investigation, 2021-05)T cells are involved in control of coronavirus disease 2019 (COVID-19), but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we used flow cytometry ... -
Post-tuberculosis lung health : perspectives from the First International Symposium
(International Union Against Tuberculosis and Lung Disease, 2020-08-01)ALTHOUGH CURABLE, TB frequently leaves the individual with chronic physical and psycho-social impairment, but these consequences have been largely neglected. The 1st International Post-Tuberculosis Symposium (Stellenbosch, ... -
Transition from restrictive to obstructive lung function impairment during treatment and follow-up of active tuberculosis
(Dove Press, 2020-05)Background: Pulmonary tuberculosis (PTB) is associated with many forms of chronic lung disease including the development of chronic airflow obstruction (AFO). However, the nature, evolution and mechanisms responsible for ... -
Fourteen-Day Bactericidal Activity, Safety, and Pharmacokinetics of Linezolid in Adults with Drug-Sensitive Pulmonary Tuberculosis
(2020-01)Background: Linezolid is increasingly used for the treatment of tuberculosis resistant to first-line agents, but the most effective dosing strategy is yet unknown. Methods: Between November 2014 and November 2016, we ... -
The utility of hand-held mobile spirometer technology in a resource-constrained setting
(Health & Medical Publishing Group, 2019)Background. Mobile phone-linked spirometry technology has been designed specifically for evaluating lung function at primary care level. The Air-Smart Spirometer is the first mobile spirometer accepted in Europe for the ... -
Relationship between chest radiographic characteristics, sputum bacterial load, and treatment outcomes in patients with extensively drug-resistant tuberculosis
(Elsevier, 2019)Background: Data about the relationship between chest radiographs and sputum bacillary load, with treatment outcomes, in patients with extensively drug-resistant tuberculosis (XDR-TB) from HIV/TB endemic settings are ... -
Recommendations for lung cancer screening in Southern Africa
(AME Publishing, 2019-07-09)ENGLISH ABSTRACT: Lung cancer remains the leading cause of cancer-related deaths in southern Africa. Early trials of chest radiograph-based screening in males at high risk for lung cancer found no mortality benefit of a ... -
Management of chronic obstructive pulmonary disease—A position statement of the South African Thoracic Society : 2019 update
(AME Publishing, 2019-10-06)ENGLISH ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a significant cause of death and disability in both developed and developing countries. It is increasing in frequency and demands increasing utilisation of ... -
An endotracheal plasmablastic lymphoma
(S. Karger AG, Basel, 2019)ENGLISH ABSTRACT: We describe an exceptionally rare case of a male patient with newly diagnosed advanced human immunodeficiency virus (HIV) infection, who presented with a plasmablastic lymphoma involving the right maxillary ... -
A severity-of-illness score in patients with tuberculosis requiring intensive care
(Health & Medical Publishing Group, 2021-03-02)Background. We previously retrospectively validated a 6-point severity-of-illness score aimed at identifying patients at risk of dying of tuberculosis (TB) in the intensive care unit (ICU). Parameters included septic shock, ... -
Corticosteroids in critical COVID-19 : are all corticosteroids equal?
(Health & Medical Publishing Group, 2021-06-04)Background. The hyperinflammation seen as part of a dysregulated immune response to SARS-CoV-2 in its most severe form leads to acute respiratory distress syndrome (ARDS), multiorgan failure and death. Corticosteroid therapy ... -
Transition from restrictive to obstructive lung function impairment during treatment and follow-up of active tuberculosis
(Dove Medical Press, 2020)Background: Pulmonary tuberculosis (PTB) is associated with many forms of chronic lung disease including the development of chronic airflow obstruction (AFO). However, the nature, evolution and mechanisms responsible for ... -
The global initiative for asthma 2019 recommendation for mild asthma – a critique
(AOSIS, 2020-03-05)Recognising that mild asthmatics are at risk of exacerbations and mortality, the Global Initiative for Asthma (GINA) issued an updated strategy in 2019. This was premised on two studies culminating in their recommendation ... -
COVID-19 in Africa : care and protection for frontline healthcare workers
(BioMed Central, 2020)Medical staff caring for COVID-19 patients face mental stress, physical exhaustion, separation from families, stigma, and the pain of losing patients and colleagues. Many of them have acquired SARS-CoV-2 and some have ... -
The utility of high-flow nasal cannula oxygen therapy in the management of respiratory failure secondary to COVID-19 pneumonia
(Health & Medical Publishing Group, 2020-05-07)COVID-19 is a potentially fatal infection caused by SARS-CoV-2.[1] As of 4 May 2020, more than 6 000 cases had been confirmed in South Africa (SA) with numbers rising steadily, a situation that will place a major strain ... -
Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion
(BMC (part of Springer Nature), 2019-12-05)Background: Bronchoalveolar lavage is a useful bronchoscopy technique. However, studies in “normal” children populations are few. Furthermore, the anti-inflammatory effects of exogenous pulmonary surfactants on ... -
Contemporary best practice in the management of malignant pleural effusion
(SAGE Publications, 2018)ENGLISH ABSTRACT: Malignant pleural effusion (MPE) affects more than 1 million people globally. There is a dearth of evidence on the therapeutic approach to MPE, and not surprisingly a high degree of variability in the ... -
Post-pulmonary tuberculosis complications in South Africa and a potential link with pulmonary hypertension : premise for clinical and scientific investigations
(Health & Medical Publishing Group, 2018)The magnitude of the pulmonary tuberculosis (TB) epidemic in South Africa (SA) and globally[1] has received increased attention. Efforts have been made to explore new and improved diagnostic[2] and treatment strategies,[3] ... -
Predictors of treatment success in smoking cessation with varenicline combined with nicotine replacement therapy v. varenicline alone
(Health & Medical Publishing Group, 2018-01)Background. Identification of the predictors of treatment success in smoking cessation may help healthcare workers to improve the effectiveness of attempts at quitting. Objective. To identify the predictors of success ... -
Five-year follow-up of participants diagnosed with chronic airflow obstruction in a South African Burden of Obstructive Lung Disease (BOLD) survey
(Health & Medical Publishing Group, 2018-02-01)Background. A community-based prevalence survey performed in two suburbs in Cape Town, South Africa (SA), in 2005, using the international Burden of Obstructive Lung Disease (BOLD) method, confirmed a prevalence of chronic ...
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