Recent Submissions

  • Renal denervation : mechanisms and clinical aspects 

    Heradien, Marshall J.; Van Der Bijl, Pieter; Brink, Paul A. (African Association of Nephrology, 2020)
    ENGLISH ABSTRACT: Hypertension is a global health issue of paramount importance, which has not spared the African continent where an unacceptably high prevalence of uncontrolled blood pressure prevails among its population. ...
  • Pattern of renal amyloidosis in South Africa 

    Hassen, Muhammed; Bates, William; Moosa, Mohammed R. (BMC (part of Springer Nature), 2019-11-09)
    Background: Kidney disease is a serious manifestation of systemic amyloidosis and a major cause of morbidity and mortality. Tuberculosis (TB) occurs up to 27 times more commonly in human immunodeficiency virus (HIV) ...
  • Salivary creatinine as a diagnostic tool for evaluating patients with chronic kidney disease 

    Temilola, Dada O.; Bezuidenhout, Karla; Erasmus, Rajiv T.; Stephen, Lawrence; Davids, Mogamat R.; Holmes, Haly (BMC (part of Springer Nature), 2019-10-29)
    Background: Preliminary studies have shown the potential use of salivary creatinine concentration in the diagnosis of chronic kidney disease (CKD). For saliva to replace serum as a diagnostic tool, studies must be done ...
  • Patterns of biopsy-proven renal disease in Cape Town, South Africa, from 1995 to 2017 

    Esmail, Ahmed M (Stellenbosch : Stellenbosch University, 2019-12)
    Introduction: The causes, prevalence and outcomes of renal disease in developing countries may differ compared to developed countries. In most African countries, little data on the topic is available because of the lack ...
  • Calcific uraemic arteriolopathy (calciphylaxis) in patients on renal replacement therapy 

    Sebastian, S.; Jordaan, H. F.; Schneider, J. W.; Moosa, M. R.; Davids, M. R. (Health and Medical Publishing Group, 2017)
    Background. Calcific uraemic arteriolopathy (calciphylaxis) is an unusual and potentially fatal condition characterised by small-vessel calcification and ischaemic skin necrosis. It mainly affects patients with end-stage ...
  • Hypernatraemia in South African hospitalized patients 

    Abohajir, Ali; Rensburg, Megan A.; Davids, M. Razeen (African Association of Nephrology, 2019)
    Background: Hypernatraemia is a common electrolyte problem in hospitalized patients and is associated with a high mortality rate. We determined the incidence, causes, management, and outcomes of hypernatraemia in ...
  • Prevalence of chronic kidney disease and association with cardiovascular risk factors among teachers in Cape Town, South Africa 

    Adeniyi, Aderemi B.; Laurence, Carien E.; Volmink, Jimmy A.; Davids, M. Razeen (Oxford University Press, 2017)
    Background: There is a need to determine the feasibility of conducting studies of chronic diseases among large cohorts of African patients. One aim of the South African feasibility study was to determine the prevalence ...
  • Hypodipsic-hypernatremia syndrome in an adult with polycythemia : a case report 

    Chothia, Mogamat-Yazied; George, Kiran; Sheik, Muhammed; Davids, Mogamat Razeen (BMC (part of Springer Nature), 2018-12-27)
    Background: Hypernatremia is a very common electrolyte disorder and is frequently encountered in out-patient as well as in-hospital settings. We describe an adult who was found to have unexplained relative polycythemia ...
  • Residual renal function in chronic dialysis is not associated with reduced erythropoietin-stimulating agent dose requirements : a cross-sectional study 

    Louw, Elizabeth Helene; Chothia, Mogamat-Yazied (BioMed Central, 2017-11-25)
    Background: Anaemia is a very common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment. Residual renal function (RRF) is ...
  • Strengthening renal registries and ESRD research in Africa 

    Davids, M. Razeen; Caskey, Fergus J.; Young, Taryn; Balbir Singh, Gillian K. (Elsevier, 2017)
    ENGLISH ABSTRACT: In Africa the combination of non-communicable diseases, infectious diseases, exposure to environmental toxins and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic ...
  • An effective approach to chronic kidney disease in South Africa 

    Moosa, Mohammed Rafique; Meyers, Anthony M.; Gottlich, Errol; Naicker, Sarala (Health & Medical Publishing Group, 2016)
    ENGLISH ABSTRACT: Very few patients with end-stage kidney disease in South Africa receive renal replacement treatment (RRT), despite the rapidly growing demand, because of resource constraints. Nephrologists who agonise ...
  • Peritoneal dialysis technique survival at Tygerberg hospital in Cape Town, South Africa 

    Kapembwa, Kenneth Chali (Stellenbosch : Stellenbosch University, 2017-03)
    Background: Peritoneal dialysis (PD) technique failure invariably occurs in patients with end-stage renal disease who are treated with this modality and results in increased morbidity and mortality. Various factors have ...
  • Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy 

    Sebastian, Sajith; Filmalter, Christelle; Harvey, Justin; Chothia, Mogamat-Yazied (Oxford University Press European Renal Association, 2016-06-19)
    Background: Intradialytic hypertension (IDH) increases morbidity and mortality. The prevalence in South Africa is unknown. The pathogenesis is unclear, but it has been suggested that IDH may be due to subclinical fluid ...
  • A renal registry for Africa : first steps 

    Davids, M. Razeen; Eastwood, John B.; Selwood, Neville H.; Arogundade, Fatiu A.; Ashuntantang, Gloria; Gharbi, Mohammed Benghanem; Jarraya, Faical; MacPhee, Iain A. M.; McCulloch, Mignon; Plange-Rhule, Jacob; Swanepoel, Charles R.; Adu, Dwomoa (Oxford University Press European Renal Association, 2016)
    ENGLISH ABSTRACT: There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African ...
  • Gitelman syndrome in a South African family presenting with hypokalaemia and unusual food cravings 

    Van der Merwe, Pieter Du Toit; Rensburg, Megan A.; Haylett, William L.; Bardien, Soraya; Davids, M. Razeen (BioMed Central, 2017-01-26)
    Background Gitelman syndrome (GS) is an autosomal recessive renal tubular disorder characterised by renal salt wasting with hypokalaemia, metabolic alkalosis, hypomagnesaemia and hypocalciuria. It is caused by mutations ...
  • Quality of life in patients on chronic dialysis in South Africa : a comparative mixed methods study 

    Tannor, Elliot K.; Archer, Elize; Kapembwa, Kenneth; Van Schalkwyk, Susan C.; Davids, M. Razeen (BioMed Central, 2017-01-05)
    Background: The increasing prevalence of treated end-stage renal disease and low transplant rates in Africa leads to longer durations on dialysis. Dialysis should not only be aimed at prolonging lives but also improve ...
  • Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans 

    Mogueo, Amelie; Echouffo-Tcheugui, Justin B.; Matsha, Tandi E.; Erasmus, Rajiv T.; Kengne, Andre P. (BioMed Central, 2015-07-04)
    Background: Chronic kidney disease (CKD) is a global challenge. Risk models to predict prevalent undiagnosed CKD have been published. However, none was developed or validated in an African population. We validated the Korean ...
  • Use of the accountability for reasonableness approach to improve fairness in accessing dialysis in a middle- income country 

    Moosa, Mohammed Rafique; Maree, Jonathan David; Chirehwa, Maxwell T.; Benatar, Solomon R. (Public Library of Science, 2016)
    Universal access to renal replacement therapy is beyond the economic capability of most low and middle-income countries due to large patient numbers and the high recurrent cost of treating end stage kidney disease. In ...
  • Important causes of chronic kidney disease in South Africa 

    Moosa, M. R.; Van der Walt, I.; Naicker, S.; Meyers, A. M. (Health & Medical Publishing Group, 2015)
    In hypertensive patients without chronic kidney disease (CKD) the goal is to keep blood pressure (BP) at ≤140/90 mmHg. When CKD is present, especially where there is proteinuria of ≥0.5 g/day, the goal is a BP of ≤130/80 ...
  • Bolus administration of intravenous glucose in the treatment of hyperkalemia : a randomized controlled trial 

    Chothia, Mogamat-Yazied; Halperin, Mitchell L.; Rensburg, Megan A.; Hassan, Mogamat Shafick; Davids, Mogamat Razeen (Karger, 2014-02)
    Background: Hyperkalemia is a common medical emergency that may result in serious cardiac arrhythmias. Standard therapy with insulin plus glucose reliably lowers the serum potassium concentration ([K + ]) but carries ...

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