Research Articles (Haematological Pathology)
Recent Submissions
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Between a rock and a hard place : COVID-19 and South Africa’s response
(Oxford University Press, 2020)The spread of COVID-19 across China, Asia, Europe and the United States of America was met with public health responses that initially encouraged hand washing and social distancing. They quickly turned to restrictions on ... -
Complete blood count reference intervals from a healthy adult urban population in Kenya
(Public Library of Science, 2018)Background: There are racial, ethnic and geographical differences in complete blood count (CBC) reference intervals (RIs) and therefore it is necessary to establish RIs that are population specific. Several studies have ... -
Cystic partially differentiated nephroblastoma-like lesion following neoadjuvant chemotherapy for nephroblastoma : a case report and review of the literature
(Elsevier, 2020)Cystic partially differentiated nephroblastoma (CPDN) and cystic nephroblastoma are paediatric renal tumours characterised by the presence of a variable combination of primitive epithelium, immature stroma and blastema. Cystic ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Castleman’s disease in the HIV-endemic setting
(Dove Medical Press, 2018)Introduction: Castleman’s disease (CD), first described by Benjamin Castleman in 1954, is a giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell lymphoproliferative disorder with ... -
The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection
(Health & Medical Publishing Group, 2014)Background. A feature of HIV/AIDS is chronic immune activation, which results in a number of complications including inflammation-related disorders and blood cytopaenias. Immune activation status is not routinely tested ... -
Immune activation is associated with decreased thymic function in asymptomatic, untreated HIV infected individuals
(AOSIS Publishing, 2016-07-28)Background: Reduced thymic function causes poor immunological reconstitution in human immunodeficiency virus (HIV)-positive patients on combined antiretroviral therapy (cART). The association between immune activation ... -
HIV/AIDS-related non-Hodgkin’s lymphomas and confounders : preliminary report of the Sub-Saharan Africa Lymphoma Consortium (SSALC)
(BioMed Central, 2012-04)SSALC was established to characterize HIV/AIDS-related lymphoma and the indigenous background of malignant lymphomas (ML) in sub-Saharan Africa. Because WHO classified lymphoma subgroups can vary in prevalence African, ... -
Biomarkers of HIV-associated cancer
(Libertas Academica, 2014)Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ... -
Recommendations for the management of sickle cell disease in South Africa
(Health & Medical Publishing Group, 2014-11)The spectrum of sickle cell disease (SCD) encompasses a heterogeneous group of disorders that include: (i) homozygous SCD (HbSS), also referred to as sickle cell anaemia; (ii) heterozygous SCD (HbAS), also referred to as ... -
The HIV/AIDS epidemic in South Africa : convergence with tuberculosis, socioecological vulnerability, and climate change patterns
(Health & Medical Publishing Group, 2014-08)Recent assessment reports suggest that climate change patterns are threatening social and ecological vulnerability and resilience, with the strong potential of negatively affecting human health. Persons living with HIV/AIDS ... -
A perpetual source of DNA or something really different : ethical issues in the creation of cell lines for African genomics research
(BioMed Central, 2014-08)Background: The rise of genomic studies in Africa - not least due to projects funded under H3Africa - is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these ... -
Modulation of LPS-induced CD4+ T-cell activation and apoptosis by antioxidants in untreated asymptomatic HIV infected participants : an in vitro study
(Hindawi Publishing Corporation, 2013-11)Persistent immune activation characterises HIV infection and is associated with depletion of CD4+ T-cells and increased risk of disease progression. Early loss of gutmucosal integrity results in the translocation of microbial ... -
Guideline for the treatment of myelodysplastic syndromes (MDS) in South Africa
(Health and Medical Publishing Group (HMPG), 2011-12)Introduction. Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal haematopoietic disorders characterised by chronic and progressive cytopenias resulting from ineffective haematopoiesis. Treatment ... -
Myelodysplastic syndromes -- Diagnosis
(Health and Medical Publishing Group (HMPG), 2012-12)This is the second in our series of clinical articles that discuss everyday presentations. Each emphasises practical aspects of team-based care that are relevant for general practitioners, specialists and paramedical ... -
Haemochromatosis : phenotype to genotype or man to molecules
(Health and Medical Publishing Group (HMPG), 2013-06)This is the third in our vignettes that are centred on everyday clinical presentations. Each emphasises practical aspects of team-based care that are applicable to general practitioners, specialists and paramedical ... -
Aplasia versus pancytopenia, including the pure red cell variant
(Health and Medical Publishing Group (HMPG), 2012-09)This is the first in our third series of clinical vignettes that are centred on everyday presentations. Each emphasises practical aspects of team-based care, having relevance for general practitioners, specialists and ... -
Association of deworming with reduced eosinophilia : implications for HIV/AIDS and co-endemic diseases
(Academy of Science of South Africa, 2003-04)Eosinophil counts in venous blood were monitored during a randomized controlled deworming trial (n = 155 children) that lasted for a year, and in a whole-school deworming programme (range 174-256 children) of 2 years' ... -
Effects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon
(Health and Medical Publishing Group (HMPG), 1974)The in vitro and in vivo hematological effects of puff adder (Bitis arietans) venom in the baboon (Papio ursinus) with regard to its effect on coagulation, fibrinolysis and platelet aggregation were studied. There is a ... -
Oorerflike faktor V gebrek (Parahemofilie) : 'n gevalbespreking
(HMPG, 1974)A white boy and his family were investigated for a haemorrhagic diathesis. Both he and his sister, a primipara between 26 and 28 wk pregnant, in May 1973 had a total lack of factor V, demonstrated an abnormal partial ...
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