Research Articles (Anatomical Pathology)
Recent Submissions
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Postmortem lung biopsies from four patients with COVID-19 at a tertiary hospital in Cape Town, South Africa
(Health & Medical Publishing Group, 2020-10-19)Background. An outbreak of a novel coronavirus in China in late 2019 has resulted in a global pandemic. The virus (SARS-CoV-2) causes a severe acute respiratory syndrome and had been responsible for >14 000 deaths in South ... -
The initial impact of the COVID-19 pandemic on the diagnosis of new cancers at a large pathology laboratory in the public health sector, Western Cape Province, South Africa
(Health & Medical Publishing Group, 2021)Background. The COVID-19 pandemic has disrupted cancer diagnostic services. A decline in the number of new cancers being diagnosed over a relatively short term implies a delay in diagnosis and subsequent treatment. This ... -
Unusual presentation of atrial myxoma : a case report and review of the literature
(International Scientific Information, 2021)BACKGROUND: Although rare, atrial myxoma is the most common benign cardiac tumor. The recognized triad of presenting symptoms relates to constitutional, embolic, and obstructive effects produced by the tumor. However, the ... -
Reclassification of early stage breast cancer into treatment groups by combining the use of immunohistochemistry and microarray analysis
(Academy of Science of South Africa, 2019)ENGLISH ABSTRACT: Immunohistochemistry (IHC) is routinely used to approximate breast cancer intrinsic subtypes, which were initially discovered by microarray analysis. However, IHC assessment of oestrogen receptor (ER), ... -
Speech production changes wih the use of a multichannel cochlear implant in postlingually hearing impaired adult
(AOSIS, 1994)Profoundly deaf cochlear implant users provide an interesting population in which to assess the role of distorted auditory feedback in speech, since their electrically stimulated hearing is significantly different from ... -
Hyperplastic polyp or sessile serrated lesion? the contribution of serial sections to reclassification
(BMC (part of Springer Nature), 2020)Background: The histological discrimination of hyperplastic polyps from sessile serrated lesions can be difficult. Sessile serrated lesions and hyperplastic polyps are types of serrated polyps which confer different ... -
Incidence of Hodgkin lymphoma in HIV-positive and HIV-negative patients at a tertiary hospital in South Africa (2005 - 2016) and comparison with other African countries
(Health & Medical Publishing Group, 2018-06-26)Background. Hodgkin lymphoma (HL) is the most common non-AIDS-defining cancer in HIV-positive patients. Studies on South African (SA) populations have described the prevalence as 7 - 17% of all lymphomas, 8 - 27% of head ... -
Fatal tumour pulmonary embolism
(Wiley Open Access, 2017)A 30-year-old female with no significant past medical history was referred to our facility with sudden onset of shortness of breath. She had a low clinical probability for pulmonary thromboembolism and a computed ... -
Colonic perineurioma (benign fibroblastic polyp) : case report and review of the literature
(BioMed Central, 2018)Background: Colorectal perineuriomas are uncommon benign mucosal-based proliferations of mesenchymal cells that express perineurial markers, often associated with colonic crypts displaying a serrated/hyperplastic ... -
Exome sequencing in a family with luminal-type breast cancer underpinned by variation in the methylation pathway
(MDPI, 2017-02-22)ENGLISH ABSTRACT: Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain ... -
A biobank to support HIV malignancy research for sub-Saharan Africa
(Health & Medical Publishing Group, 2016)Sub-Saharan Africa has one of the highest incidences of infection with HIV globally, but more people in this region are living longer owing to increased access to antiretroviral therapy. However, along with increased care ... -
Histological and immunohistochemical evaluation of sentinel lymph nodes in breast cancer at a tertiary hospital in the Western Cape, South Africa
(Health & Medical Publishing Group, 2016-04-19)Background. Breast carcinoma remains the most prevalent cancer among women, with over 300 000 deaths annually worldwide. Axillary lymph node status is essential for the clinical staging of breast carcinoma and remains the ... -
Non-allopathic adjuvant management of osteoarthritis by alkalinisation of the diet
(AOSIS Publishing, 2015)Background: Osteoarthritis (OA) is a chronic condition. Nonsteroidal anti-inflammatory drugs recommended for treatment have serious adverse effects. A compelling body of anecdotal evidence alerted the authors to the ... -
The role of MKP-1 in the anti-proliferative effects of glucocorticoids in primary rat pre-osteoblasts
(Public Library of Science, 2015)Glucocorticoid (GC)-induced osteoporosis has been attributed to a GC-induced suppression of pre-osteoblast proliferation. Our previous work identified a critical role for mitogen-activated protein kinase (MAPK) phosphatase-1 ... -
MammaPrint Pre-screen Algorithm (MPA) reduces chemotherapy in patients with early-stage breast cancer
(Health & Medical Publishing Group, 2013-07-03)Background. Clinical and pathological parameters may overestimate the need for chemotherapy in patients with early-stage breast cancer. More accurate determination of the risk of distant recurrence is now possible with use ... -
An evaluation of the diagnostic adequacy and immunocytochemistry of manual liquid-based smears in breast aspirates
(Medpharm Publications, 2013)The aim of this study was to determine if the Syner-Med®/Cell-Solutions® liquid-based cytology (LBC) technique would provide adequate diagnostic material when applied to breast fine-needle aspiration biopsy (FNAB) specimens ... -
The quality of specimens obtained by fine-needle aspiration biopsy : does training make a difference?
(Medpharm Publications, 2012)Background: The aim of this study was to determine the outcome of a one-hour training session on the correct technique of fine-needle aspiration biopsy (FNAB) by assessing adequacy of FNAB specimens received from clinicians ... -
Exome sequencing combined with semantic discovery identifies strong disease-associated candidates in a single case of relapsing remitting multiple sclerosis
(BioMed Central, 2012-10)As known disease-associated variants identified through large cohort-based studies often explain only a small percentage of genetic risk in multifactorial disorders such as multiple sclerosis (MS), alternative methods ... -
Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer’s disease
(SpringerLink, 2012-04)Chronic, multi-factorial conditions caused by a complex interaction between genetic and environmental risk factors frequently share common disease mechanisms, as evidenced by an overlap between genetic risk factors ... -
Complex patterns of genomic admixture within Southern Africa
(PLOS, 2013-03)Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the ...
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