Research Articles (Anatomical Pathology)
Recent Submissions
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Incidence of Hodgkin lymphoma in HIV-positive and HIV-negative patients at a tertiary hospital in South Africa (2005 - 2016) and comparison with other African countries
(Health & Medical Publishing Group, 2018-06-26)Background. Hodgkin lymphoma (HL) is the most common non-AIDS-defining cancer in HIV-positive patients. Studies on South African (SA) populations have described the prevalence as 7 - 17% of all lymphomas, 8 - 27% of head ... -
Fatal tumour pulmonary embolism
(Wiley Open Access, 2017)A 30-year-old female with no significant past medical history was referred to our facility with sudden onset of shortness of breath. She had a low clinical probability for pulmonary thromboembolism and a computed ... -
Colonic perineurioma (benign fibroblastic polyp) : case report and review of the literature
(BioMed Central, 2018)Background: Colorectal perineuriomas are uncommon benign mucosal-based proliferations of mesenchymal cells that express perineurial markers, often associated with colonic crypts displaying a serrated/hyperplastic ... -
Exome sequencing in a family with luminal-type breast cancer underpinned by variation in the methylation pathway
(MDPI, 2017-02-22)ENGLISH ABSTRACT: Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain ... -
A biobank to support HIV malignancy research for sub-Saharan Africa
(Health & Medical Publishing Group, 2016)Sub-Saharan Africa has one of the highest incidences of infection with HIV globally, but more people in this region are living longer owing to increased access to antiretroviral therapy. However, along with increased care ... -
Histological and immunohistochemical evaluation of sentinel lymph nodes in breast cancer at a tertiary hospital in the Western Cape, South Africa
(Health & Medical Publishing Group, 2016-04-19)Background. Breast carcinoma remains the most prevalent cancer among women, with over 300 000 deaths annually worldwide. Axillary lymph node status is essential for the clinical staging of breast carcinoma and remains the ... -
Non-allopathic adjuvant management of osteoarthritis by alkalinisation of the diet
(AOSIS Publishing, 2015)Background: Osteoarthritis (OA) is a chronic condition. Nonsteroidal anti-inflammatory drugs recommended for treatment have serious adverse effects. A compelling body of anecdotal evidence alerted the authors to the ... -
The role of MKP-1 in the anti-proliferative effects of glucocorticoids in primary rat pre-osteoblasts
(Public Library of Science, 2015)Glucocorticoid (GC)-induced osteoporosis has been attributed to a GC-induced suppression of pre-osteoblast proliferation. Our previous work identified a critical role for mitogen-activated protein kinase (MAPK) phosphatase-1 ... -
MammaPrint Pre-screen Algorithm (MPA) reduces chemotherapy in patients with early-stage breast cancer
(Health & Medical Publishing Group, 2013-07-03)Background. Clinical and pathological parameters may overestimate the need for chemotherapy in patients with early-stage breast cancer. More accurate determination of the risk of distant recurrence is now possible with use ... -
An evaluation of the diagnostic adequacy and immunocytochemistry of manual liquid-based smears in breast aspirates
(Medpharm Publications, 2013)The aim of this study was to determine if the Syner-Med®/Cell-Solutions® liquid-based cytology (LBC) technique would provide adequate diagnostic material when applied to breast fine-needle aspiration biopsy (FNAB) specimens ... -
The quality of specimens obtained by fine-needle aspiration biopsy : does training make a difference?
(Medpharm Publications, 2012)Background: The aim of this study was to determine the outcome of a one-hour training session on the correct technique of fine-needle aspiration biopsy (FNAB) by assessing adequacy of FNAB specimens received from clinicians ... -
Exome sequencing combined with semantic discovery identifies strong disease-associated candidates in a single case of relapsing remitting multiple sclerosis
(BioMed Central, 2012-10)As known disease-associated variants identified through large cohort-based studies often explain only a small percentage of genetic risk in multifactorial disorders such as multiple sclerosis (MS), alternative methods ... -
Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer’s disease
(SpringerLink, 2012-04)Chronic, multi-factorial conditions caused by a complex interaction between genetic and environmental risk factors frequently share common disease mechanisms, as evidenced by an overlap between genetic risk factors ... -
Complex patterns of genomic admixture within Southern Africa
(PLOS, 2013-03)Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the ... -
CYP2D6 genotyping and use of antidepressants in breast cancer patients : test development for clinical application
(Springer Verlag, 2012-05)Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase ... -
Mycobacterial transport medium for routine culture of fine needle aspiration biopsies
(BMJ Publishing Group, 2010-01)Fine needle aspiration biopsy (FNAB) offers a simple outpatient technique for specimen collection in child tuberculosis suspects with peripheral lymphadenopathy. To perform FNAB with mycobacterial culture on an outpatient ... -
Malacoplakia of the vagina : first case report
(HMPG, 1973-08)The first case of malacoplakia known to have affected the female genital tract is presented. This lesion involved the upper vagina and presented clinically as an infiltrating carcinoma. No evidence of malacoplakia of ... -
Metastatic hepatocellular carcinoma of the heart. A case report
(HMPG, 1978)A metastatic tumour growing in the heart more than 2 years after total removal of the primary hepatic growth is a rare event. Jaundice as a result of bile production by the metastasis is most unusual. The primary tumour ... -
Unusual presentation of choriocarcinoma. A case report
(Health and medical Publishing Group (HMPG), 1979-01)Authors report the management of a case of malignant trophoblastic disease which presented initially as a haematemesis and melaena from a gastric metastasis. The patient had had a tubal sterilization 4 years previously. ... -
Gangrene of the penis after circumcision : a report of 3 cases
(HMPG, 1979-03)Three patients with gangrene of the penis after Xhosa ritual tribal circumcision are reported. A review of complications which may follow circumcision is given.
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