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Research Articles (General Internal Medicine)
Recent Submissions
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Effect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in research collaboration
(2020-12)In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), ... -
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation
(Nature Research (part of Springer Nature), 2019-02-28)Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid ... -
Post-tuberculosis health-related quality of life, lung function and exercise capacity in a cured pulmonary tuberculosis population in the Breede Valley District, South Africa
(AOSIS, 2019)Background: Pulmonary tuberculosis (PTB) remains a major concern worldwide. Albeit curable, PTB continues to negatively affect patients’ health-related quality of life (HRQoL) and functioning even after cure. Objectives: To ... -
Reconceptualising health professions education in South Africa
(Academy of Science of South Africa, 2018)No abstract available. -
Hereditary angio-oedema in the Western Cape Province, South Africa
(Health & Medical Publishing Group, 2018-03-28)Background. Hereditary angio-oedema (HAE) is an autosomal dominant condition caused by a deficiency in the C1-esterase inhibitor protein, resulting in increased bradykinin release. It presents clinically with recurrent ... -
Seasonal variations in tuberculosis diagnosis among HIV-positive individuals in Southern Africa : analysis of cohort studies at antiretroviral treatment programmes
(BMJ Publishing Group, 2018-01)Objectives Seasonal variations in tuberculosis diagnoses have been attributed to seasonal climatic changes and indoor crowding during colder winter months. We investigated trends in pulmonary tuberculosis (PTB) diagnosis ... -
South African guideline on deep brain stimulation for Parkinson’s disease
(Health & Medical Publishing Group, 2017)Background. Parkinson’s disease (PD) is a common neurodegenerative disease, associated with severe impairment of quality of life. Although the motor aspects of the illness are typically successfully treated with medications ... -
A retrospective study evaluating the efficacy of identification and management of sepsis at a district-level hospital internal medicine department in the Western Cape Province, South Africa, in comparison with the guidelines stipulated in the 2012 Surviving Sepsis Campaign
(Health & Medical Publishing Group, 2017)Background. Currently there is little information on the identification, management and outcomes of patients with sepsis in developing countries. Simple cost-effective measures such as accurate identification of patients ... -
A refined multiscale self-entropy approach for the assessment of cardiac control complexity : application to long QT syndrome type 1 patients
(MDPI, 2015-11-13)ENGLISH ABSTRACT: The study proposes the contemporaneous assessment of conditional entropy (CE) and self-entropy (sE), being the two terms of the Shannon entropy (ShE) decomposition, as a function of the time scale via ... -
Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial
(BioMed Central, 2016)Background: The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin ... -
Low-Pass filtering approach via empirical mode decomposition improves short-scale entropy-based complexity estimation of QT interval variability in long QT syndrome type 1 patients
(MDPI, 2014-09-05)Entropy-based complexity of cardiovascular variability at short time scales is largely dependent on the noise and/or action of neural circuits operating at high frequencies. This study proposes a technique for canceling ... -
South African renal registry annual report 2012
(South African Renal Society, 2012-04)INTRODUCTION: This first report of the new South African Renal Registry provides data on renal replacement therapy (RRT) for patients with end-stage renal disease (ESRD) in South Africa. Our previous registry, the ... -
Neurological ageing factors : neurobiology of ageing and prevention of dementia
(Health & Medical Publishing Group, 2005-06)By the year 2000 the total human population passed the 6 billion mark. It is estimated to peak at 9 billion around 2070 before declining to 8.4 billion at the end of the century. The decline will largely be due to reduced ... -
Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on antiretroviral therapy
(Public Library of Science (PLOS), 2008-05)Background World Health Organization (WHO) guidelines for monitoring HIV-infected individuals taking combination antiretroviral therapy (cART) in resource-limited settings recommend using CD4þ T cell (CD4) count changes ... -
The outcome of HIV-positive patients admitted to intensive care units with acute kidney injury
(InTech, 2012)Acute kidney injury is a serious clinical problem with significant morbidity and mortality. Several factors are recognized to aggravate the outcome including advanced age, gender, oliguria and the serum creatinine level. ... -
Abnormal serum lipoprotein levels as a risk factor for the development of human lenticular opacities
(Clinics Cardiv Publishing, 2003-04)Aim: To determine whether an association exists between the different plasma lipoprotein constituents and the prevalence of lenticular opacities in dyslipidaemic subjects. Methods: Adult patients (n = 115) of both genders ... -
Patients’ motivations for participating in cardiovascular clinical trials : a local perspective
(Clinics Cardiv Publishing, 2009-08)Objective: To investigate patients’ motivations for participating in cardiovascular clinical trials. Methods: Patients attending TREAD Research, located within Tygerberg Hospital, Parow, Western Cape, between January 2005 ... -
Mendelian-inherited heart disease : a gateway to understanding mechanisms in heart disease : update on work done at the University of Stellenbosch
(Clinics Cardiv Publishing, 2009-02)The presence of founder effects in South Africa for many single-gene diseases, which include heart diseases such as progressive familial heart block types I and II, hypertrophic cardiomyopathy and the long QT syndromes, ... -
A comparison of stimulation frequency and electro-augmentation on Myocardial function, extensibility, coronary flow rate, oxygen consumption and glucose metabolism
(Clinics Cardiv Publishing, 2009-02)See full text. -
Beta-blockers and the treatment of hypertension : it is time to move on
(Clinics Cardiv Publishing, 2007-12)Existing solid scientific evidence with hard outcome data should be the basis for treatment guidelines, and where such evidence is lacking, we must invest in research. A case in point is the initiation of antihypertensive ...
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