Recent Submissions

  • Highly active antiretroviral therapy alters sperm parameters and testicular antioxidant status in diet-induced obese rats 

    Oyeyipo, Ibukun P.; Skosana, Bongekile T.; Everson, Frans P.; Strijdom, Hans; Du Plessis, Stefan S. (Korean Society of Toxicology, 2018)
    The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo ...
  • Nutritional support in sepsis : when less may be more 

    Van Niekerk, Gustav; Meaker, Charne; Engelbrecht, Anna-Mart (BMC (part of Springer Nature), 2020-02-14)
    Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelming. ...
  • The prevalence of type 2 diabetes in South Africa : a systematic review protocol 

    Pheiffer, Carmen; Pillay-Van Wyk, Victoria; Joubert, Jane D.; Levitt, Naomi; Nglazi, Mweete D.; Bradshaw, Debbie (BMJ Publishing Group, 2018-06)
    Introduction Type 2 diabetes mellitus is a major source of morbidity and mortality in South Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local epidemiological data are required to inform ...
  • High fat programming and cardiovascular disease 

    Cerf, Marlon E. (MDPI, 2018)
    ENGLISH ABSTRACT: Programming is triggered through events during critical developmental phases that alter offspring health outcomes. High fat programming is defined as the maintenance on a high fat diet during fetal and/or ...
  • Cardiac glucolipotoxicity and cardiovascular outcomes 

    Cerf, Marlon E. (MDPI, 2018)
    Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the ...
  • Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis 

    Van der Meeren, Olivier; Hatherill, Mark; Nduba, Videlis; Wilkinson, Robert J.; Muyoyeta, Monde; Van Brakel, Elana; Ayles, Helen M.; Henostroza, German; Thienemann, Friedrich; Scriba, Thomas J.; Diacon, Andreas; Blatner, Gretta L.; Demoitie, Marie-Ange; Tameris, Michele; Malahleha, Mookho; Innes, James C.; Hellstrom, Elizabeth; Martinson, Neil; Singh, Tina; Akite, Elaine J.; Khatoon Azam, Aisha; Bollaerts, Anne; Ginsberg, Ann M.; Evans, Thomas G.; Gillard, Paul; Tait, Dereck R. (Massachusetts Medical Society, 2018-10-25)
    BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South ...
  • Spermatozoa : a historical perspective 

    Suarez, Jenniffer Puerta; Du Plessis, Stefan S.; Maya, Walter D. C. (Royan Institute, 2018)
    ENGLISH ABSTRACT: The 100,000th scientific article on the subject of spermatozoa was recently published. Numerous studies evaluated the characteristics of this important cell that led to tremendous discoveries. Since its ...
  • Revisiting the relationship between the ejaculatory abstinence period and semen characteristics 

    Ayad, Bashir M.; Van der Horst, Gerhard; Du Plessis, Stefan S. (Royan Institute, 2018)
    ENGLISH ABSTRACT: Variation in the ejaculatory abstinence period suggested by different guidance bodies have resulted in a growing concern among researchers and clinicians over what the precise period of ejaculatory ...
  • Blood-based DNA methylation biomarkers for type 2 diabetes : potential for clinical applications 

    Willmer, Tarryn; Johnson, Rabia; Louw, Johan; Pheiffer, Carmen (Frontiers Media, 2018)
    ENGLISH ABSTRACT: Type 2 diabetes (T2D) is a leading cause of death and disability worldwide. It is a chronic metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental factors. The ...
  • Diabetes mellitus and male infertility 

    Omolaoye, Temidayo; Du Plessis, Stefan S. (Medknow, 2018)
    ENGLISH ABSTRACT: Infertility is prevalent in about 10%-25% of couples in their reproductive age, analogous to 60-80 million infertile couples globally. Of these infertility cases, 10%-30% are exclusively attributed to ...
  • Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation 

    Blignaut, Marguerite; Loos, Ben; Botchway, Stanley W.; Parker, Anthony W.; Huisamen, Barbara (Springer Nature, 2019)
    The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial ...
  • Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage : a protocol for a systematic review 

    Dludla, Phiwayinkosi V.; Nkambule, Bongani B.; Dias, Stephanie C.; Johnson, Rabia (BMC (part of Springer Nature), 2017)
    Background: Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM ...
  • Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir, emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats 

    Everson, Frans; Genis, Amanda; Ogundipe, Temitope; De Boever, Patrick; Goswami, Nandu; Lochner, Amanda; Blackhurst, Dee; Strijdom, Hans (Public Library of Science, 2018-12-05)
    HIV-infection, certain antiretroviral drug classes, especially protease inhibitors (PI), and obesity are associated with increased ischaemic heart disease (IHD) risk. However, the effect of PI-free fixed dose combination ...
  • Xpert MTB/RIF assay shows faster clearance of Mycobacterium tuberculosis DNA with higher levels of rifapentine exposure 

    Jayakumar, A.; Savic, R. M.; Everett, C. K.; Benator, D.; Alland, D.; Heilig, C. M.; Weiner, M.; Friedrich, S. O.; Martinson, N. A.; Kerrigan, A.; Zamudio, C.; Goldberg, S. V.; Whitworth, W. C.; Davis, J. L.; Nahid, P. (American Society for Microbiology, 2016-12)
    The Xpert MTB/RIF assay is both sensitive and specific as a diagnostic test. Xpert also reports quantitative output in cycle threshold (CT ) values, which may provide a dynamic measure of sputum bacillary burden when used ...
  • Toxicity associated with tuberculosis chemotherapy in the REMoxTB study 

    Tweed, Conor D.; Crook, Angela M.; Amukoye, Evans I.; Dawson, Rodney; Diacon, Andreas H.; Hanekom, Madeline; McHugh, Timothy D.; Mendel, Carl M.; Meredith, Sarah K.; Murphy, Michael E.; Murthy, Saraswathi E.; Nunn, Andrew J.; Phillips, Patrick P. J.; Singh, Kasha P.; Spigelman, Melvin; Wills, Genevieve H.; Gillespie, Stephen H. (BioMed Central, 2018-07-11)
    Background: The incidence and severity of tuberculosis chemotherapy toxicity is poorly characterised. We used data available from patients in the REMoxTB trial to provide an assessment of the risks associated with the ...
  • Aspalathin reverts doxorubicin-induced cardiotoxicity through increased autophagy and decreased expression of p53/mTOR/p62 signaling 

    Johnson, Rabia; Shabalala, Samukelisiwe; Louw, Johan; Kappo, Abidemi Paul; Muller, Christo John Frederick (MDPI, 2017-11-01)
    ENGLISH ABSTRACT: Doxorubicin (Dox) is an effective chemotherapeutic agent used in the treatment of various cancers. Its clinical use is often limited due to its potentially fatal cardiotoxic side effect. Increasing evidence ...
  • Cardiomyocyte differentiation : experience and observations from 2 laboratories 

    Patten, Victoria; Chabaesele, I.; Sishi, Balindiwe; Van Vuuren, Derick (South African Heart Association, 2017)
    The undifferentiated clonal cell line, H9c2, derived from left ventricular rat heart tissue, has been extensively used in cardiovascular research. In the present study, 2 independent laboratories aimed to investigate the ...
  • Ameliorative potentials of quercetin against cotinine-induced toxic effects on human spermatozoa 

    Goss, Dale; Oyeyipo, Ibukun P.; Skosana, Bongekile T.; Ayad, Bashir M.; Du Plessis, Stefan S. (Hainan Medical University Journal Publisher, 2016)
    Objectives: Cotinine, the principal metabolite of nicotine found in smokers' seminal plasma, has been shown to adversely affect sperm functionality while quercetin, a flavonoid with diverse properties is associated with ...
  • Critical appraisal of conventional semen analysis in the context of varicocele 

    Kruger, Thinus (Frontiers Media, 2016)
    Varicocele is present in approximately 15% of men, and, although it is the most commonly diagnosed cause of male infertility, nearly two-thirds of men with varicoceles remain fertile. It was decided to make use of the ...
  • AMP kinase activation and glut4 translocation in isolated cardiomyocytes 

    Webste, Ingrid; Friedrich, Sven O.; Lochner, Amanda; Huisamen, Barbara (Clinics Cardive Publishing, 2010-04)
    Activation of AMP-activated protein kinase (AMPK) results in glucose transporter 4 (GLUT4) translocation from the cytosol to the cell membrane, and glucose uptake in the skeletal muscles. This increased activation of AMPK ...

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