Research Articles (Molecular Biology and Human Genetics)
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Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis : a combined in silico and in vitro study
(Elsevier, 2019)ENGLISH ABSTRACT: The shortcomings of conventional tuberculosis treatments resulting from the development of drug resistance in Mycobacterium tuberculosis drive a need for the formulation of novel therapeutic agents. The ... -
Overcoming limitations of tuberculosis information systems : researcher and clinician perspectives
(International Union Against Tuberculosis and Lung Disease, 2019)Setting: Tuberculosis (TB) diagnosis and treatment requires patients to have multiple encounters with health care systems and the different stakeholders who play a role in curing them to coordinate their efforts. To ... -
Discovery and validation of a prognostic proteomic signature for tuberculosis progression : a prospective cohort study
(Public Library of Science, 2019)Background: A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to ... -
Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation
(ARKAT USA, 2019)ENGLISH ABSTRACT: 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the ... -
Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm
(Nature Research, 2019-09-17)ENGLISH ABSTRACT: Abdominal aortic aneurysm (AAA) is characterized by transmural infiltration of myeloid cells at the vascular injury site. Previously, we reported preventive effects of Notch deficiency on the development ... -
Tuberculosis research in South Africa over the past 30 years : from bench to bedside
(South African Medical Association, 2019-12-05)ENGLISH ABSTRACT: The South African Medical Research Council Centre for Tuberculosis Research has a rich history of high-impact research that has influenced our understating of this hyper-epidemic which is further exacerbated ... -
Bioactive compounds and biological functions of garlic (Allium sativum L.)
(MDPI, 2019)ENGLISH ABSTRACT: Garlic (Allium sativum L.) is a widely consumed spice in the world. Garlic contains diverse bioactive compounds, such as allicin, alliin, diallyl sulfide, diallyl disulfide, diallyl trisulfide, ajoene, ... -
Detection of tuberculosis recurrence, diagnosis and treatment response by a blood transcriptomic risk signature in HIV-infected persons on antiretroviral therapy
(Frontiers Media, 2019)ENGLISH ABSTRACT: HIV-infected individuals are at high risk of tuberculosis disease and those with prior tuberculosis episodes are at even higher risk of disease recurrence. A non-sputum biomarker that identifies individuals ... -
On the impact of the pangenome and annotation discrepancies while building protein sequence databases for bacteria proteogenomics
(Frontiers Media, 2019)ENGLISH ABSTRACT: In proteomics, peptide information within mass spectrometry (MS) data from a specific organism sample is routinely matched against a protein sequence database that best represent such organism. However, ... -
Antibacterial activities of crude secondary metabolite extracts from pantoea species obtained from the stem of solanum mauritianum and their effects on two cancer cell lines
(MDPI, 2019)ENGLISH ABSTRACT: Endophytes are microorganisms that are perceived as non-pathogenic symbionts found inside plants since they cause no symptoms of disease on the host plant. Soil conditions and geography among other factors ... -
Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa : a retrospective cohort analysis
(Public Library of Science, 2019-10-17)ENGLISH ABSTRACT: South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a ... -
Relationships between housing and management factors and clinical health events in elephants in North American zoos
(Public Library of Science, 2019-06-06)ENGLISH ABSTRACT: Elephants experience a number of health issues that can contribute to their well-being and survival. In managed populations, housing conditions and management practices can influence individual health, ... -
The level of the endoplasmic reticulum stress chaperone protein, binding immunoglobulin protein (BiP), decreases following successful tuberculosis treatment
(Elsevier, 2019)ENGLISH ABSTRACT: An increased Mycobacterium tuberculosis burden inside the host leads to higher demand of response proteins. This in turn results in metabolic shift and cellular stress, which is caused by the accumulation ... -
Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell–killing capability
(American Society for Clinical Investigation, 2019)ENGLISH ABSTRACT: Tuberculosis patients and mice infected with live Mycobacterium tuberculosis accumulate high numbers of myeloid-derived suppressor cells (MDSCs). Here, we hypothesized that dead M. tuberculosis vaccines ... -
Detection of second line drug resistance among drug resistant Mycobacterium tuberculosis isolates in Botswana
(MDPI, 2019-10-28)ENGLISH ABSTRACT: The emergence and transmission of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis (M.tb) strains is a threat to global tuberculosis (TB) control. The early detection ... -
Long-term impact of neonatal intake of oleanolic acid on the expression of AMP-activated protein kinase, adiponectin and inflammatory cytokines in rats fed with a high fructose diet
(MDPI, 2019-01-22)ENGLISH ABSTRACT: AMP-activated protein kinase (AMPK) is known to regulate both glucose and lipid metabolism, which play vital roles in the development of metabolic syndrome. One way of regulating AMPK is through hormonal ... -
Bedaquiline microheteroresistance after cessation of tuberculosis treatment
(Massachusetts Medical Society, 2019-05-30)ENGLISH ABSTRACT: Bedaquiline improves survival among persons with multidrug-resistant tuberculosis (MDR-TB).1 We report the case of a 65-year-old South African man who was negative for human immunodeficiency virus and in ... -
Effect of Xpert MTB/RIF on clinical outcomes in routine care settings : individual patient data meta-analysis
(Elsevier, 2019-02)Background: Xpert MTB/RIF, the most widely used automated nucleic acid amplification test for tuberculosis, is available in more than 130 countries. Although diagnostic accuracy is well documented, anticipated improvements ... -
Evaluating antibacterial and anticancer activity of crude extracts of bacterial endophytes from Crinum macowanii Baker bulbs
(Wiley Open Access, 2019)The results from this study revealed that crude extracts isolated from bacterial endophytes obtained from Crinum macowanii bulbs showed activity against both Gram-positive and Gram-negative pathogenic bacteria, while ... -
Bcells and their regulatory functions during Tuberculosis : latency and active disease
(Elsevier, 2019)ENGLISH ABSTRACT: Tuberculosis (TB) is a global epidemic with devastating consequences. Emerging evidence suggests that B-cells have the ability to modulate the immune response and understanding these roles during Mycobacterium ...
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