Research Articles (Molecular Biology and Human Genetics)
Recent Submissions
-
Elucidation of a human urine metabolite as a seryl-leucine glycopeptide and as a biomarker of effective anti-tuberculosis therapy
(American Chemical Society, 2018-12-26)ENGLISH ABSTRACT: The evaluation of new tuberculosis (TB) therapies is limited by the paucity of biomarkers to monitor treatment response. Previous work detected an uncharacterized urine metabolite with a molecular mass ... -
Genetic association of lipids and lipid drug targets with abdominal aortic aneurysm : a meta-analysis
(American Medical Association, 2018)Importance Risk factors for abdominal aortic aneurysm (AAA) are largely unknown, which has hampered the development of nonsurgical treatments to alter the natural history of disease. Objective To investigate the ... -
Epidemiology of tuberculosis in multi-host wildlife systems : implications for black (diceros bicornis) and white (ceratotherium simum) rhinoceros
(Frontiers Media, 2020)Cases of tuberculosis (TB) resulting from infection with Mycobacterium tuberculosis complex (MTBC) have been recorded in captive white (Ceratotherium simum) and black (Diceros bicornis) rhinoceros. More recently, cases ... -
Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease
(BioMed Central, 2020-10-01)Background: Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually ... -
Novel kinase platform for the validation of the anti-tubercular activities of Pelargonium sidoides (Geraniaceae)
(BMC (part of Springer Nature), 2020-09-29)Background: Pelargonium sidoides is an important traditional medicine in South Africa with a well-defined history of both traditional and documented use of an aqueous-ethanolic formulation of the roots of P. sidoides (EPs ... -
Turning up the volume for precision herbal medicine in Africa in an era of COVID-19 and planetary biodiversity loss
(Mary Ann Liebert, 2020)What would it take in terms of the structural reforms in science, technology, and culture to cultivate sustainable therapeutic and preventive medicine innovations against zoonotic infections such as coronavirus disease ... -
The VetMAX™ M. tuberculosis complex PCR kit detects MTBC DNA in antemortem and postmortem samples from white rhinoceros (Ceratotherium simum), African elephants (Loxodonta africana) and African buffaloes (Syncerus caffer)
(BMC (part of Springer Nature), 2020)Background: Bovine tuberculosis and tuberculosis are chronic infectious diseases caused by the Mycobacterium tuberculosis complex members, Mycobacterium bovis and Mycobacterium tuberculosis, respectively. Infection with ... -
Identification of a novel WAS mutation in a South African patient presenting with atypical Wiskott-Aldrich syndrome : a case report
(BioMed Central, 2020-06-05)Background: The X-linked recessive primary immunodeficiency disease (PIDD) Wiskott-Aldrich syndrome (WAS) is identified by an extreme susceptibility to infections, eczema and thrombocytopenia with microplatelets. ... -
Extract from used Xpert MTB/ RIF Ultra cartridges is useful for accurate second-line drug-resistant tuberculosis diagnosis with minimal rpoB-amplicon cross-contamination risk
(Nature Research (part of Springer Nature), 2020)Xpert MTB/RIF Ultra (Ultra) detects Mycobacterium tuberculosis and rifampicin resistance. Follow-on drug susceptibility testing (DST) requires additional sputum. Extract from the diamond-shaped chamber of the cartridge ... -
Association of simple renal cysts and chronic kidney disease with large abdominal aortic aneurysm
(BMC (part of Springer Nature), 2020-05-29)Background: Abdominal aortic aneurysms (AAA) primarily affect men over 65 years old who often have many other diseases, with similar risk factors and pathobiological mechanisms to AAA. The aim of this study was to assess the ... -
Charge syndrome : genetic aspects and dental challenges, a review and case presentation
(BMC (part of Springer Nature), 2020-05-08)Background: CHARGE syndrome (CS) is a rare genetic condition (OMIM #214800). The condition has a variable phenotypic expression. Historically, the diagnosis of CHARGE syndrome was based on the presence of specific clinical ... -
Identifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics
(BioMed Central, 2020-03-23)Background: Transcriptional responses required to maintain cellular homeostasis or to adapt to environmental stress, is in part mediated by several nucleic-acid associated proteins. In this study, we sought to establish ... -
Putting RFMix and ADMIXTURE to the test in a complex admixed population
(BMC (part of Springer Nature), 2020)Background: Global and local ancestry inference in admixed human populations can be performed using computational tools implementing distinct algorithms. The development and resulting accuracy of these tools has been ... -
Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa : a systematic review
(BMC (part of Springer Nature), 2020)Background: The burden of drug resistant tuberculosis in Africa is largely driven by the emergence and spread of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis strains. MDR-TB is ... -
Automated IS6110-based fingerprinting of Mycobacterium tuberculosis : reaching unprecedented discriminatory power and versatility
(Public Library of Science, 2018)Background: Several technical hurdles and limitations have restricted the use of IS6110 restriction fragment length polymorphism (IS6110 RFLP), the most effective typing method for detecting recent tuberculosis (TB) ... -
Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa
(Public Library of Science, 2018-08-01)Objective: To investigate the distribution of Mycobacterium tuberculosis genotypes across Africa. Methods: The SITVIT2 global repository and PUBMED were searched for spoligotype and published genotype data respectively, ... -
Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique
(Public Library of Science, 2018)Bovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal products. In order to ... -
Margarida Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique
(Public Library of Science, 2018)ENGLISH ABSTRACT: Bovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal ... -
Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis
(Nature Research, 2018-02-08)We investigated host-derived biomarkers that were previously identified in QuantiFERON supernatants, in a large pan-African study. We recruited individuals presenting with symptoms of pulmonary TB at seven peripheral ... -
Modulation of inflammatory cytokines and islet morphology as therapeutic mechanisms of Basella alba in streptozotocin-induced diabetic rats
(Korean Society of Toxicology, 2018)The mechanism of the previously reported antidiabetic effect of Basella alba is unknown. This study investigated the role of B. alba aqueous leaf extract in the modulation of inflammatory cytokines and islet morphology ...
RSS 1.0