Research Articles (Molecular Biology and Human Genetics)
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The neuromyelitis optica presentation and the aquaporin-4 antibody in HIV-seropositive and seronegative patients in KwaZulu-Natal, South Africa
(AOSIS Publishing, 2017)Background: The association of the anti-aquaporin-4 (AQP-4) water channel antibody with neuromyelitis optica (NMO) syndrome has been described from various parts of the world. There has been no large study describing this ... -
Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression
(Public Library of Science, 2017)Aims: Infiltration of macrophages and apoptosis of vascular smooth muscle cells (VSMCs) promote the development of abdominal aortic aneurysm (AAA). Previously, we demonstrated that global Notch1 deficiency prevents the ... -
A sex-stratified genome-wide association study of tuberculosis using a multi-ethnic genotyping array
(Frontiers Media, 2019)Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a complex disease with a known human genetic component. Males seem to be more affected than females and in most countries the TB notification rate is twice as ... -
Evaluating the accuracy of imputation methods in a five-way admixed population
(Frontiers Media, 2019)Genotype imputation is a powerful tool for increasing statistical power in an association analysis. Meta-analysis of multiple study datasets also requires a substantial overlap of SNPs for a successful association analysis, ... -
Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and anatomical pathology
(Public Library of Science, 2017)Tuberculosis caused by Mycobacterium bovis is endemic in the African buffalo (Syncerus caffer) population in the Kruger National Park and other conservation areas in South Africa. The disease has been diagnosed in a total ... -
Paratuberculosis in a domestic dog in South Africa
(AOSIS Publishing, 2017)This case report shows that Mycobacterium avium subsp. paratuberculosis (MAP) infection can cause clinical disease in domestic dogs, and should be considered as a differential diagnosis for gastrointestinal inflammatory ... -
Current use and acceptability of novel diagnostic tests for active tuberculosis : a worldwide survey
(Sociedade Brasileira de Pneumologia e Tisiologia, 2017-09-03)Objective: To determine the current use and potential acceptance (by tuberculosis experts worldwide) of novel rapid tests for the diagnosis of tuberculosis that are in line with World Health Organization target product ... -
A pilot study evaluating the utility of commercially available antibodies for flow cytometric analysis of Panthera species lymphocytes
(BMC (part of Springer Nature), 2018-12-19)Background: The immune response against tuberculosis in lions is still poorly defined and our understanding is hampered by the lack of lion specific reagents. The process for producing antibodies against a specific antigen ... -
The X chromosome and sex-specific effects in infectious disease susceptibility
(BMC (part of Springer Nature), 2019-01-08)ENGLISH ABSTRACT: The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome. ... -
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform
(Public Library of Science, 2017-03-29)ENGLISH ABSTRACT: Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl ... -
Detection of a combination of serum IgG and IgA antibodies against selected mycobacterial targets provides promising diagnostic signatures for active TB
(Impact Journals, 2017-03-24)ENGLISH ABSTRACT: Immunoglobulin G (IgG) based tests for the diagnosis of active tuberculosis (TB) disease often show a lack of specificity in TB endemic regions, which is mainly due to a high background prevalence of ... -
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
(Nature Research (part of Springer Nature), 2017)ENGLISH ABSTRACT: The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic ... -
Genetic resistance to mycobacterium tuberculosis infection and disease
(Frontiers Media, 2017)Natural history studies of tuberculosis (TB) have revealed a spectrum of clinical outcomes after exposure to Mycobacterium tuberculosis, the cause of TB. Not all individuals exposed to the bacterium will become diseased ... -
Exome sequencing identifies a novel MAP3K14 mutation in recessive atypical combined immunodeficiency
(Frontiers, 2017-11)ENGLISH ABSTRACT: Primary immunodeficiency disorders (PIDs) render patients vulnerable to infection with a wide range of microorganisms and thus provide good in vivo models for the assessment of immune responses during ... -
The kinetics of the humoral and interferon-gamma immune responses to experimental Mycobacterium bovis infection in the white rhinoceros (Ceratotherium simum)
(Frontiers, 2017-12)ENGLISH ABSTRACT: Mycobacterium bovis is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (Ceratotherium simum). Control of the disease relies on the indirect detection of infection ... -
TBVAC2020 : advancing tuberculosis vaccines from discovery to clinical development
(Frontiers, 2017-10)TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early ... -
Impact of alcohol consumption on tuberculosis treatment outcomes : a prospective longitudinal cohort study protocol
(BioMed Central, 2018-09-29)Background: An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not ... -
Susceptibility to tuberculosis is associated with PI3K-dependent increased mobilization of neutrophils
(Frontiers Media, 2018)Neutrophilia is a condition commonly observed in patients with late-stage tuberculosis, but evidence suggests that increased neutrophil influx begins early after infection in susceptible hosts and functions to promote a ... -
Direct susceptibility testing of Mycobacterium tuberculosis for Pyrazinamide by Use of the Bactec MGIT 960 system
(American Society for Microbiology, 2016-05)Pyrazinamide (PZA) is a key antituberculosis drug, yet no rapid susceptibility test is commercially available. PZA drug susceptibility testing (DST) was performed directly on sputum samples from 327 patients and compared ... -
GenoType MTBDRsl assay for resistance to second-line anti-tuberculosis drugs
(Cochrane, 2016-09-08)Background: Genotype® MTBDRsl (MTBDRsl) is a rapid DNA-based test for detecting specific mutations associated with resistance to fluoroquinolones and second-line injectable drugs (SLIDs) in Mycobacterium tuberculosis ...
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