Masters Degrees (Chemical Pathology)
Recent Submissions
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Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study)
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT : Chronic kidney disease (CKD) is described as abnormal kidney function in which one third is lost over a period of 3 months and is a global epidemic with a particularly concentrated incidence within ... -
The development and application of a polymerase chain reaction (PCR) based assay to determine the impact of genetic variation in South African patients diagnosed with depression
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Major Depressive Disorder (MDD) is a severe debilitating medical condition that may lead to suicide. Due to a poor understanding of the biological mechanisms underlying the disease process therapeutic ... -
Analysis of single nucleotide polymorphisms with opposite effects on serum iron parameters in South African patients with multiple sclerosis
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: There is growing interest in how genetic and environmental risk factors interact to confer risk for dysregulated iron homeostasis, which is considered a possible pathogenic mechanism in multiple sclerosis ... -
Development of a high-throughput genotyping assay for detection of functional polymorphisms involved in homocysteine metabolism and the methylation process implicated in multiple sclerosis
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: The aetiology of multiple sclerosis (MS) remains largely unknown due to the multifactorial nature of disease susceptibility determined by both environmental and genetic factors. Progress has been made ... -
Investigation of the relationship between genetic and environmental risk factors associated with obesity and insulin resistance in South African patients with non-alcoholic fatty liver disease(NAFLD)
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The disease spectrum of NAFLD extends from steatosis (types 1,2) to non-alcoholic steatohepatitis (NASH) ... -
The occurance of genetic variations in the MYH9 gene and their association with CKD in a mixed South African population
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: The purpose of this study was to investigate the association of the selected MYH9 single nucleotide polymorphisms (SNPs) with chronic kidney disease (CKD) and its related co-morbidities in the South African ... -
Free light chains in patients with HIV: establishing local reference ranges and their association with stage of disease, chronic antigen stimulation and the effect of Haart
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Background: Serum free light chains (FLC) are associated with imbalances in heavy and light chain production. Abnormal FLC ratios have been associated with risk of progression in certain diseases. ... -
Lipoprotein X : biochemical predictors and detection by non-denaturing polyacrylamide gradient gel electrophoresis
(Stellenbosch : Stellenbosch University, 2007-12)ENGLISH ABSTRACT: Lipoprotein X (LpX) is an abnormal cholesterol-containing particle that may be present in the serum of subjects with cholestasis, lecithin:cholesterol acyltransferase (LCAT) deficiency and parenteral ... -
Development of a pathology-supported genetic test for improved clinical management of patients diagnosed with multiple sclerosis
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: The aetiology of multiple sclerosis (MS) remains largely unknown, due to its multifactorial nature with environmental and genetic factors contributing to the risk. Several investigations highlighted the ...
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