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Doctoral Degrees (Paediatrics and Child Health)
Recent Submissions
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Clinical predictors of pulmonary embolism in pregnancy and immediate postpartum period: a retrospective, analytical study
(Stellenbosch : Stellenbosch University, 2022, 2022-12)ENGLISH ABSTRACT: Background Although pulmonary embolism (PE) is one of the leading causes of death in pregnancy and postpartum, it has low risk of adverse outcome if diagnosed early and treated appropriately. Ventila ... -
Non-invasive cardiac output monitoring in preterm neonates
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Neonatal hemodynamic compromise is linked to numerous adverse neonatal outcomes. Objective, comprehensive, continuous hemodynamic monitoring of the systemic circulation, in conjunction with the pulmonary ... -
Tuberculosis-associated mortality in South Africa: longitudinal trends and the impact of health system interventions
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Tuberculosis (TB) is estimated to have infected a quarter of the world’s population. In 2019, it was estimated that 10 million people developed TB globally and that the treatment coverage was 71%. In ... -
Improving early diagnosis and referrals to life-saving care for children with cancer in Cameroon
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Childhood cancer is curable, but survival rates in low- and middle-income countries (LMICs), especially sub-Saharan Africa, are generally low. In 2018, the International Society of Paediatric ... -
A comparative study of neuroprotective strategies and outcomes in neonatal hypoxic ischaemic encephalopathy
(Stellenbosch : Stellenbosch University, 2021-03)Background Hypoxic ischaemic encephalopathy affects 1.15 million neonates annually worldwide, the majority of whom are in low to middle income countries. It is the leading cause of death of term neonates in South Africa. ... -
The management and outcomes of neuroblastoma in South Africa
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Neuroblastoma (NB) is the second most diagnosed childhood solid tumour in high-income countries (HIC), but the incidence has not accurately been described in low- and middle-income countries ... -
Complementary surveillance strategies and interventions to inform a tuberculosis care cascade for children
(Stellenbosch : Stellenbosch University, 2021, 2020-12)ENGLISH ABSTRACT: Monitoring and evaluation is an integral component of tuberculosis (TB) control programmes. Children 0-14 years of age contribute substantially to the global TB epidemic, with an estimated 1 million ... -
Neuro-imaging in paediatric HIV, a MRI/DTI study
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: The HIV epidemic has been largely controlled by antiretroviral treatment (ART) which improves neurodevelopmental outcomes. Nevertheless, many HIV-infected (HIV+) children on long-term treatment may have ... -
And therapeutic outcomes lopinavir-ritonavir and a rifampicin containing anti-tuberculosis pharmacokinetics in children with tuberculosis/hiv co-infection treated with regimen
(Stellenbosch : Stellenbosch University, 2019-10-15)ENGLISH ABSTRACT: Background Despite the scale-up of the prevention of mother to child transmission of HIV, an estimated 240,000 children were infected in 2013. Currently, The Joint United Nations Programme on HIV and ... -
The neurodevelopmental outcomes of perinatally HIV-infected children on different antiretroviral treatment (ART) strategies
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: At the commencement of this study, it was apparent that antiretroviral therapy (ART) improved neurodevelopmental outcomes of children infected with HIV. Little was known about the long-term ... -
Neurodevelopmental and behavioural outcome of the HIV-exposed uninfected infant and child
(Stellenbosch : Stellenbosch University., 2020-03)ENGLISH ABSTRACT: The first 1000 days of life represents a crucial phase for cognitive, language and emotional development. Indeed, early childhood development provides a foundation for educational and vocational success. ... -
Addressing critical knowledge gaps to improve and shorten multidrug-resistant tuberculosis treatment regimens in children
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Multidrug-resistant (MDR) tuberculosis (TB), defined as TB disease or infection caused by Mycobacterium tuberculosis with resistance to at least both isoniazid and rifampicin, threatens global TB ... -
Innovative strategies to improve the diagnosis of intrathoracic tuberculosis in children
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Paediatric tuberculosis (TB) contributes approximately 10% of the global TB burden, with over one million estimated new cases and 253,000 TB-related deaths in children during 2016. Paediatric TB is a ... -
The impact of the HPTN 071 (PopART) intervention on mortality and AIDS related morbidity amongst HIV positive adults in South Africa
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: In 2015 WHO recommended antiretroviral treatment (ART) for all HIV-positive individuals regardless of CD4 count and set a target for Universal Access to ART, that >80% of HIV-positive individuals should ... -
Mathematical modelling to project the impact of interventions targeted to previously treated individuals on the trajectory of the tuberculosis epidemic in high tuberculosis prevalence settings
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Better strategies are needed to reduce Mycobacterium tuberculosis (M.tb) transmission in tuberculosis (TB) high-incidence settings. Targeting additional control interventions towards groups at highest TB ... -
How can virtual implementation modelling inform the scale-up of new molecular diagnostic tools for tuberculosis?
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: The aim of this dissertation was to develop an operational model to explain why the expected increase in the number of tuberculosis (TB) cases detected was not found in our empirical study, Policy ... -
Evaluating the impact of an Xpert® MTB/RIF- based TB diagnostic algorithm in a routine operational setting in Cape Town
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: Decades of reliance on slow, inaccurate diagnostic tests have contributed to poor case detection and impeded tuberculosis (TB) control efforts globally. The development of an accurate, rapid molecular ... -
Determinants of healthcare-associated infection among hospitalized children
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: Healthcare-associated infection (HAI) is the most frequent complication of hospitalization resulting in suffering, excess mortality and increased healthcare costs. Although paediatric HAI burden and impact ... -
Prevention and treatment of perinatal and infant tuberculosis in the HIV era
(Stellenbosch : Stellenbosch University, 2016-11-18)ENGLISH ABSTRACT : Infants (<12 months) born to women with tuberculosis are at high risk of Mycobacterium tuberculosis (M. tuberculosis) exposure, infection and disease early in life. In settings with high prevalence of ... -
Social and contextual factors affecting HIV-infected women’s feeding practices for their infants in normal practice settings : effects on growth and morbidity
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: the significant reduction in HIV transmission through breastfeeding by antiretroviral treatment guided the current recommendations favouring breastfeeding which has to be continued until 12 months of ...
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