Masters Degrees (Physiological Sciences)
Recent Submissions
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Investigating the amyloidogenic potential of serum amyloid a in type ii diabetes mellitus
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Introduction: Type II Diabetes Mellitus (T2DM) is a non-communicable disease associated with chronic low-grade inflammation and persistent activation of the acute phase response (APR). Serum amyloid A ... -
The role of lipoteichoic acid on amyloidogenesis and its effect on erythrocytes and platelets
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Hypercoagulation and amyloidogenesis are commonly known as hallmarks for inflammation. Hypercoagulation and amyloidogenesis are linked to quite a few communicable and non-communicable ailments such as ... -
The role of Gingko biloba extract on autophagy modulation, protein clearance and neuronal cell death in an in vitro model of Alzheimer's disease
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Introduction: Alzheimer’s disease (AD) is a complex neurological disease, characterized by two protein aggregate forms, namely extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary ... -
Neuromuscular junction endplate morphology, acetylcholine receptor aggregation and accessory protein co-localisation during regeneration of a skeletal muscle crush injury
(Stellenbosch : Stellenbosch University, 2019-02)ENGLISH ABSTRACT: At the neuromuscular junction (NMJ), peripheral nerves innervate the skeletal muscle to relay neural transmission. The acetylcholine receptors (AChRs) are located on the post-synaptic membrane and ... -
Investigating the effects of diet-induced obesity on acute Doxorubicin-induced cardiotoxicity in a tumour-bearing model
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Introduction: Obesity is a well-known global pandemic that is fundamentally caused by an energy imbalance between calories consumed and calories expended. A major consequence to obesity are metabolic ... -
A matter of life or death : autophagy in the context of prolonged doxorubicin therapy
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Introduction Doxorubicin (DOX) is an effective treatment against a variety of cancers, and thus remains a commonly used chemotherapeutic drug. The chief side effect of DOX treatment is cardiotoxicity. ... -
Dynamic interactions between skeletal muscle and breast cancer cells following chemotherapeutic treatment
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Background: Breast cancer is the most common cancer found among women of South Africa with the prominent effective form of treatment being chemotherapy. Many cancer patients receiving chemotherapeutic ... -
The comparison between two high-intensity interval training protocols on skeletal muscle and satellite cell dynamics
(Stellenbosch : Stellenbosch University, 2019-02)ENGLISH ABSTRACT: Introduction: High intensity interval training (HIIT) interventions are popularly used by endurance athletes to increase muscle strength, peak speed and aerobic capacity. Running involves the use of both ... -
The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Introduction: Breast cancer is frequently diagnosed in women in both developed and developing countries and poses a major health problem throughout the world. The current standard treatment for breast ... -
Potential for modulation of cancer-associated oxidative stress : an in vitro investigation
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: While cancer is a chronic, complex disease associated with a multitude of steps in its initiation and progression, all cancers generally have similar underlying maladaptive physiological mechanisms which ... -
TKTL1 plays a critical role in ameliorating intracellular oxidative stress under hyperglycemic conditions
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Diabetes is a growing, global concern, reaching a prevalence far beyond the projected statistics. Hyperglycemia is a common denominator of type 1 and type 2 diabetes mellitus that if left untreated, ... -
Investigating the effects of chronic doxorubicin and ghrelin treatment on hepatic tissue
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX) is an effective and widely used chemotherapeutic agent. However, its toxicity on healthy tissue limits its usage. DOX is known to induce damage mainly via oxidative stress ... -
Neuro- and immunomodulatory effects of Sceletium tortuosum
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Chronic lifestyle stress translates to chronic physiological and psychological conditions. Continual stress-response activation plays a key role in the development of inflammatory diseases, such as diabetes, ... -
Investigation into potential endocrine disruptive effects of Sceletium tortuosum
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Depression has been recognised by the World Health Organisation (WHO) as the leading cause of disability, affecting an estimated 300 million people globally. To date antidepressants are prescribed as the ... -
The potential toxic effects of chronic doxorubicin treatment on the rat pancreas and the role of ghrelin in this context
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX), is a chemotherapeutic drug that has potent anti-neoplastic actions. It is for this reason that it remains one of the most widely used chemotherapeutic agents that has led ... -
Ageing-associated oxidative stress and inflammation are alleviated by products from grapes
(Hindawi, 2016)Advanced age is associated with increased incidence of a variety of chronic disease states which share oxidative stress and inflammation as causative role players. Furthermore, data point to a role for both cumulative ... -
Exosome dynamics and changes in a selection of their microRNA cargo in response to an acute bout of eccentrically-biased exercise in healthy human volunteers
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Background: Extracellular vesicles (EVs) are nanoscale (30 to 1000 nm diameter) mediators of intercellular information transfer, shuttling diverse cargos including functional nucleic acids, proteins and ... -
Development of a transendothelial shuttle by macrophage modification
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Background: Targeted stem cell delivery via macrophage modification is a novel and relatively non-invasive therapeutic intervention. Monocytes circulate through the vasculature and infiltrate damaged ... -
Elucidation of molecular mechanisms that may contribute to polyphenol-induced effects on neutrophil chemokinesis
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Grape-derived products are high in polyphenols and are known to have anti-oxidant and anti-inflammatory effects. In vivo studies in the context of muscle injury-induced inflammation have proven grape ... -
Are early proteomic and metabolic changes induced by long-term sugar-sweetened beverage consumption the key to unlocking the cardio-metabolic pandemic?
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: INTRODUCTION: Cardio-metabolic diseases (e.g. type 2 diabetes mellitus) are a major cause of mortality worldwide. The incidence of cardio-metabolic diseases continues to increase, especially in low and ...
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