Masters Degrees (Physiological Sciences)
Recent Submissions
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The cellular response of triple-negative breast cancer to short-term starvation: implications for chemosensitivity
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Introduction: Breast cancer is currently the most common cancer among women globally. Triplenegative breast cancer (TNBC) is an aggressive and often drug-resistant sub-type of breast cancer that is ... -
Establishing and validating an unpredictable chronic mild stress rat model in a South African laboratory
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: There is growing concern regarding the societal implications of the increasing burden of chronic stress. In light of this, there are countless animal studies that are currently pursuing the underlying ... -
An evaluation of the role of platelet activation in HIV-related cardiovascular diseases onset
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Background: Although combined anti-retroviral treatment (cART) lowered HIV-AIDS onset, HIVpositive individuals display increased cardiovascular disease (CVD) onset. Enhanced myocardial fibrosis has ... -
The effects of bacterial inflammagens from Porphyromonas gingivalis on blood clotting
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Abnormal blood coagulation, systemic inflammation and microbial dysbiosis are shared pathological characteristics of cardiovascular and neurodegenerative diseases. In addition, defective clotting processes ... -
A comparison of the wound healing dynamics in an acute and newly developed chronic wound model using Neutral endopeptidase, an inhibitor of Substance P.
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Chronic wounds affect millions of people with diabetes world-wide. Various diabetic wound healing animal models exist, none of which currently replicate chronic wounds in diabetic patients. Animal models ... -
The endothelium: an essential barrier between chronic stress and vascular pathology
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: In recent years, chronic stress has emerged as an influential and understudied risk factor for the onset of cardiovascular disease. While much is known regarding the physiological systems that orchestrate ... -
An assessment of ischemia-reperfusion injury in rats exposed to chronic psychological stress
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Cardiovascular disease remains the leading cause of death worldwide. Apart from known risk factors such as poor dietary intake, physical inactivity and smoking, chronic psychological stress is emerging as ... -
Investigating the amyloidogenic potential of serum amyloid a in type ii diabetes mellitus
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Introduction: Type II Diabetes Mellitus (T2DM) is a non-communicable disease associated with chronic low-grade inflammation and persistent activation of the acute phase response (APR). Serum amyloid A ... -
The role of lipoteichoic acid on amyloidogenesis and its effect on erythrocytes and platelets
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Hypercoagulation and amyloidogenesis are commonly known as hallmarks for inflammation. Hypercoagulation and amyloidogenesis are linked to quite a few communicable and non-communicable ailments such as ... -
The role of Gingko biloba extract on autophagy modulation, protein clearance and neuronal cell death in an in vitro model of Alzheimer's disease
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Introduction: Alzheimer’s disease (AD) is a complex neurological disease, characterized by two protein aggregate forms, namely extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary ... -
Neuromuscular junction endplate morphology, acetylcholine receptor aggregation and accessory protein co-localisation during regeneration of a skeletal muscle crush injury
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: At the neuromuscular junction (NMJ), peripheral nerves innervate the skeletal muscle to relay neural transmission. The acetylcholine receptors (AChRs) are located on the post-synaptic membrane and ... -
Investigating the effects of diet-induced obesity on acute Doxorubicin-induced cardiotoxicity in a tumour-bearing model
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Introduction: Obesity is a well-known global pandemic that is fundamentally caused by an energy imbalance between calories consumed and calories expended. A major consequence to obesity are metabolic ... -
A matter of life or death : autophagy in the context of prolonged doxorubicin therapy
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Introduction Doxorubicin (DOX) is an effective treatment against a variety of cancers, and thus remains a commonly used chemotherapeutic drug. The chief side effect of DOX treatment is cardiotoxicity. ... -
Dynamic interactions between skeletal muscle and breast cancer cells following chemotherapeutic treatment
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Background: Breast cancer is the most common cancer found among women of South Africa with the prominent effective form of treatment being chemotherapy. Many cancer patients receiving chemotherapeutic ... -
The comparison between two high-intensity interval training protocols on skeletal muscle and satellite cell dynamics
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Introduction: High intensity interval training (HIIT) interventions are popularly used by endurance athletes to increase muscle strength, peak speed and aerobic capacity. Running involves the use of both ... -
The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Introduction: Breast cancer is frequently diagnosed in women in both developed and developing countries and poses a major health problem throughout the world. The current standard treatment for breast ... -
Potential for modulation of cancer-associated oxidative stress : an in vitro investigation
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: While cancer is a chronic, complex disease associated with a multitude of steps in its initiation and progression, all cancers generally have similar underlying maladaptive physiological mechanisms which ... -
TKTL1 plays a critical role in ameliorating intracellular oxidative stress under hyperglycemic conditions
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Diabetes is a growing, global concern, reaching a prevalence far beyond the projected statistics. Hyperglycemia is a common denominator of type 1 and type 2 diabetes mellitus that if left untreated, ... -
Investigating the effects of chronic doxorubicin and ghrelin treatment on hepatic tissue
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX) is an effective and widely used chemotherapeutic agent. However, its toxicity on healthy tissue limits its usage. DOX is known to induce damage mainly via oxidative stress ... -
Neuro- and immunomodulatory effects of Sceletium tortuosum
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Chronic lifestyle stress translates to chronic physiological and psychological conditions. Continual stress-response activation plays a key role in the development of inflammatory diseases, such as diabetes, ...
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