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Doctoral Degrees (Clinical Pharmacology)
Recent Submissions
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Development of a direct ADR reporting tool for patients to address under-reporting of ADRs to the National Pharmacovigilance Unit in South Africa
(Stellenbosch : Stellenbosch University, 2022-12)ENGLISH ABSTRACT: High standards of public health can be achieved through efficient and safe utilisation of healthcare products and the continuous monitoring thereof. Pharmacovigilance (PV), defined as the science and ... -
Drug repurposing and optimisation to improve tuberculosis treatment
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Tuberculosis, a leading infectious cause of mortality, morbidity, and reduced quality of life with loss of income, remains a huge public health burden particularly in resource-limited settings. The golden ... -
Intravitreal Bevacizumab as anti-vascular endothelial growth factor in the management of complications of diabetic retinopathy
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Bevacizumab is a complete full-length humanized antibody that binds to all subtypes of vascular endothelial growth factor (VEGF) and is used successfully in tumor therapy as a systemic drug. Recent ... -
Pharmacokinetic Herb-Drug Interactions involving african traditional medicines - fingerprint analysis and in vitro metabolism studies
(Stellenbosch : Stellenbosch University, 2018-12)Introduction Traditional, complementary and alternative medicines have been used to treat various health conditions. The use of such medicines among HIV/AIDS and TB patients in sub- Saharan Africa has increased considerably, ... -
Immunoactive, Antibacterial and Drug-Carrying properties of selective surfactants
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Surfactant replacement therapy is used the treatment of neonatal respiratory distress syndrome as surfactant’s biophysical behaviour helps to maintain proper lung function and reduces the work associated ... -
Biomarkers of HIV associated malignancies and of drug interaction between anti-retrovirals (ARVs) and chemotherapy
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: INTRODUCTION: Altered immune mechanisms play a critical role in the pathogenesis of Non-Hodgkin lymphoma (NHL), as evidenced by increased rates of NHL among HIV+ patients [De Roos et al., 2012; Mellgren ... -
Pharmacokinetic herb-drug interaction study of selected traditional medicines used as complementary and alternative medicine (CAM) for HIV/AIDS
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Introduction The increasing intake of traditional medicines among HIV/AIDS patients in sub-Saharan Africa needs urgent consideration by clinicians and other healthcare providers since the safety of such ... -
In vitro assessment of some traditional medications used in South Africa for pharmacokinetics drug interaction potential
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Introduction Earlier studies have shown the popularity of herbal products among people as traditional, complementary or alternative medication. One of the major clinical risks in the concomitant administration ... -
A critical appraisal of the clinical pharmacokinetics of isoniazid
(Stellenbosch : University of Stellenbosch, 1996-12)The work presented in this thesis has contributed to the clarification of a number of issues related to the clinical pharmacokinetics of isoniazid and hydrozine in juvenile and adult patients of both sexes subject to ...
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