Department of Physiological Sciences
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Investigations into the cytotoxic mechanism of action for the garlic compound ajoene and its derivatives in breast cancer cells
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Breast cancer continues to place a severe burden on women globally. There has been a growing interest in natural compounds for cancer prevention, with several phytochemicals possessing anti-cancer ... -
The role of Serum Amyloid A in NLRP3 inflammasome signalling in breast and colon cancer
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Introduction: Cancer is a complex disease with multiple interactions targeting the organism on cellular, tissue and systemic levels. The main research focus for the past decades has been on the genome ... -
Molecular regulation of autophagy and metastasis in breast cancer: new insights into the role of serum amyloid A
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Introduction: Cytokines, growth factors and acute phase proteins present in the tumour microenvironment regulate inflammatory responses and alter crosstalk between various signalling pathways involved ... -
Intercellular communication between macrophages, myoblasts and fibroblasts in the context of rheumatoid arthritis-associated skeletal muscle wasting
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Approximately 1% of the global population is afflicted with rheumatoid arthritis (RA), of which over a third experience rheumatoid cachexia, a RA-specific form of skeletal muscle wasting. Current patient ... -
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation
(Nature Research (part of Springer Nature), 2019-02-28)Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid ... -
Small extracellular vesicle dynamics and microRNA cargo in response to gradient specific high intensity running
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Skeletal muscle adaptation in response to exercise is a highly dynamic process and small extracellular vesicles (EVs) (30-150 nm) are postulated to be mediators of intercellular communication during ... -
A possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura : results from a pilot study
(Frontiers Media, 2019-11-26)Introduction: Migraine is a debilitating primary headache disorder with a poorly understood aetiology. An extensive body of literature supports the theory of migraine as a systemic vascular inflammatory disorder characterised ... -
The impact of sugar-sweetened beverage intake on rat cardiac function
(Elsevier, 2019-03-12)Aims: Although there is evidence linking sugar-sweetened beverage (SSB) intake with the development of cardio-metabolic diseases, the underlying mechanisms remain unclear. The current study therefore evaluated the effects ... -
Bacterial dysbiosis and translocation in psoriasis vulgaris
(Frontiers Media, 2019-02-04)Psoriasis vulgaris is a chronic inflammatory skin condition, associated with both a physical and a psychological burden. Our understanding of the etiology of this disease remains incomplete. Conventionally, psoriasis has ... -
The impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysis
(MDPI, 2020)Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this ... -
The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells
(Springer Nature, 2019-01-28)Rhabdomyosarcoma (RMS) forms in skeletal muscle and is the most common soft tissue sarcoma in children and adolescents. Current treatment is associated with debilitating side effects and treatment outcomes for patients ... -
Effects of redox disturbances on motility, contractility and muscle tissue pathogenesis
(Hindawi, 2019-06-16)Whether in health or disease, reactive oxygen and nitrogen species (ROS/RNS) affect smooth and striated muscle status and function in ways not always discernible or appreciated. Despite the technological and methodological ... -
Investigating aberrant DNA methylation patterns in LOXL2 as a potential predictor of diabetes-induced cardiac dysfunction
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with 17.9 million deaths annually. CVD pathophysiology is often characterized by increased stiffening of the heart muscle ... -
Schizophrenia: Effect of Fluanxol® treatment on redox status
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Oxidative stress has been implicated in the pathology of schizophrenia, with impaired antioxidant mechanisms observed in these patients. The modulatory role of oxidative stress on the activity of NMDA ... -
The cellular response of triple-negative breast cancer to short-term starvation: implications for chemosensitivity
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Introduction: Breast cancer is currently the most common cancer among women globally. Triplenegative breast cancer (TNBC) is an aggressive and often drug-resistant sub-type of breast cancer that is ... -
An investigation into the role of Serum amyloid A in breast cancer
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: Cancer remains a global challenge that affects many lives. To this extent, much research has gone into understanding this disease and the factors that contribute to it. Over the past 40 years, an ... -
Establishing and validating an unpredictable chronic mild stress rat model in a South African laboratory
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: There is growing concern regarding the societal implications of the increasing burden of chronic stress. In light of this, there are countless animal studies that are currently pursuing the underlying ... -
An evaluation of the role of platelet activation in HIV-related cardiovascular diseases onset
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Background: Although combined anti-retroviral treatment (cART) lowered HIV-AIDS onset, HIVpositive individuals display increased cardiovascular disease (CVD) onset. Enhanced myocardial fibrosis has ... -
An investigation into the role of Serum amyloid A in breast cancer
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Cancer remains a global challenge that affects many lives. To this extent, much research has gone into understanding this disease and the factors that contribute to it. Over the past 40 years, an ... -
Identification of potential biomarkers of cardiotoxicity induced by doxorubicin therapy in a tumour bearing model by targeting specific micro-RNAs
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Introduction: Anthracycline-induced cardiotoxicity, a major side effect of chemotherapeutic drugs such as doxorubicin (DOX), has been a priority within the field of cardio-oncology for a number of decades. ...
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