Medical Microbiology
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Association between clinical and environmental factors and the gut microbiota profiles in young South African children
(Nature Research (part of Springer Nature), 2021)ENGLISH ABSTRACT: Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe the baseline or control microbiota in each ... -
Optimizing antibiotic prescribing : collective approaches to managing a common-pool resource
(Wiley, 2019)Background: Antimicrobial resistance (AMR) is one of the greatest threats in 21st century medicine. AMR has been characterized as a social dilemma. A familiar version describes the situation in which a collective resource ... -
Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial
(Elsevier, 2019)Background: New anti-tuberculosis regimens that are shorter, simpler, and less toxic than those that are currently available are needed as part of the global effort to address the tuberculosis epidemic. We aimed to investigate ... -
Carbapenemase-producing Enterobacteriaceae colonisation in adult inpatients : a point prevalence study
(AOSIS, 2019)Background: Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) have been increasing worldwide in recent years, but data regarding the prevalence and clinical significance of CPE colonisation in South ... -
Clonal expansion of colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa
(Elsevier, 2020)Objectives: To describe colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa. Methods: A. baumannii isolates identified on Vitek 2 Advanced Expert System were collected from Tygerberg Hospital ... -
Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
(AOSIS, 2021)ENGLISH ABSTRACT: Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage ... -
Characterisation of mcr-4.3 in a colistin-resistant Acinetobacter nosocomialis clinical isolate from Cape Town, South Africa
(Elsevier, 2021)Objectives: Colistin resistance in Acinetobacter spp. is increasing, resulting in potentially untreatable noso- comial infections. Plasmid-mediated colistin resistance is of particular concern due to its low fitness cost ... -
Characterisation of mobile colistin resistance genes (mcr‑3 and mcr‑5) in river and storm water in regions of the Western Cape of South Africa
(BMC (part of Springer Nature), 2021)Background: Colistin is regarded as a last-resort antimicrobial against multi-drug resistant Gram-negative bacteria (GNB), therefore the dissemination of colistin resistance in the environment is of great concern. Horizontal ... -
Bacterial infection, antibiotic use and COVID-19 : lessons from the intensive care unit
(Health & Medical Publishing Group, 2021-04-14)Background. Empirical broad-spectrum antibiotics are frequently prescribed to patients with severe COVID-19, motivated by concern about bacterial coinfection. There is no evidence of benefit from such a strategy, while the ... -
Investigating the role of respiratory co-infections and the nasopharyngeal microbiome in children with suspected pulmonary tuberculosis
(Stellenbosch : Stellenbosch University, 2020-12)Introduction: Tuberculosis (TB) is a global health problem, causing morbidity, mortality and devastating social and economic impacts. Pediatric TB is particularly challenging due to difficulties in diagnosis. ... -
The effect of storage conditions on microbial communities in stool
(Public Library of Science, 2020)Microbiome research has experienced a surge of interest in recent years due to the advances and reduced cost of next-generation sequencing technology. The production of high quality and comparable data is dependent on ... -
The association between pathogen factors and clinical outcomes in patients with Staphylococcus aureus bacteraemia in a tertiary hospital, Cape Town
(Elsevier on behalf of International Society for Infectious Diseases, 2019-11-29)Background: Staphylococcus aureus is a serious pathogen, able to cause life-threatening infections such as bacteraemia. The association between S. aureus microbial characteristics and clinical outcomes is under- investigated ... -
The prevalence and molecular mechanisms of mupirocin resistance in Staphylococcus aureus isolates from a Hospital in Cape Town, South Africa
(BMC (part of Springer Nature), 2020-03-14)Abstract Background: Antimicrobial resistance is an increasingly serious problem in public health globally. Monitoring resistance levels within healthcare and community settings is critical to combat its ongoing increase. ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Optimisation and comparison of a phenotypic maldi-tof assay with molecular and phenotypic methods for the rapid identification of selected fungal, nocardia and nontuberculous mycobacteria.
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been utilised in clinical microbiology laboratories for several years, but is mostly used for the rapid and ... -
The carriage of antimicrobial resistance in community children – a TB-CHAMP sub-study.
(Stellenbosch : Stellenbosch University., 2019-12)Introduction: The world-wide rise in antimicrobial resistance (AMR) is threatening the effectivity of antibiotics and the control of infectious diseases. The challenge of AMR is considerably exacerbated by the presence ... -
One Health approach in the prevention and control of mycobacterial infections in Tanzania : lessons learnt and future perspectives
(BMC (part of Springer Nature), 2019-11-27)Background: One Health (OH) is an integrated approach, formed inclusive of using multiple disciplines to attain optimal health for humans, animals, and the environment. The increasing proximity between humans, livestock, ... -
Laboratory based antimicrobial resistance surveillance for Pseudomonas aeruginosa blood isolates from South Africa
(Journal of Infection in Developing Countries, 2018)Introduction: Antimicrobial resistant bacterial infections are widespread globally and increases in antimicrobial resistance presents a major threat to public health. Pseudomonas aeruginosa is an opportunistic healthcare ... -
Whole-genome sequence of a mycobacterium goodii isolate from a pediatric patient in South Africa
(American Society for Microbiology, 2018)ENGLISH ABSTRACT: We describe here the draft genome sequence of a Mycobacterium goodii isolate from a pediatric patient in Western Cape, South Africa. To our knowledge, this is the second reported genome of this rapidly ... -
The carriage of antibiotic resistant Gram-negative organisms in children in the Cape Town community and the impact of antibiotic exposure on the development of resistance (a TB-CHAMP sub-study)
(Stellenbosch : Stellenbosch University, 2019-12)Introduction Antibiotic resistance has become a major issue across the globe and the situation is worsening in low- and middle-income countries. In sub-Saharan Africa and the world at large, antibiotic resistance research ...
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