Medical Microbiology
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B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
One Health approach in the prevention and control of mycobacterial infections in Tanzania : lessons learnt and future perspectives
(BMC (part of Springer Nature), 2019-11-27)Background: One Health (OH) is an integrated approach, formed inclusive of using multiple disciplines to attain optimal health for humans, animals, and the environment. The increasing proximity between humans, livestock, ... -
Laboratory based antimicrobial resistance surveillance for Pseudomonas aeruginosa blood isolates from South Africa
(Journal of Infection in Developing Countries, 2018)Introduction: Antimicrobial resistant bacterial infections are widespread globally and increases in antimicrobial resistance presents a major threat to public health. Pseudomonas aeruginosa is an opportunistic healthcare ... -
Whole-genome sequence of a mycobacterium goodii isolate from a pediatric patient in South Africa
(American Society for Microbiology, 2018)ENGLISH ABSTRACT: We describe here the draft genome sequence of a Mycobacterium goodii isolate from a pediatric patient in Western Cape, South Africa. To our knowledge, this is the second reported genome of this rapidly ... -
The carriage of antibiotic resistant Gram-negative organisms in children in the Cape Town community and the impact of antibiotic exposure on the development of resistance (a TB-CHAMP sub-study)
(Stellenbosch : Stellenbosch University, 2019-12)Introduction Antibiotic resistance has become a major issue across the globe and the situation is worsening in low- and middle-income countries. In sub-Saharan Africa and the world at large, antibiotic resistance research ... -
Xenorhabdus khoisanae SB10 produces Lys-rich PAX lipopeptides and a Xenocoumacin in its antimicrobial complex
(BMC (part of Springer Nature), 2019-06-13)Background: Xenorhabdus spp. live in close symbiosis with nematodes of the Steinernema genus. Steinernema nematodes infect an insect larva and release their symbionts into the haemocoel of the insect. Once released into the ... -
Development of functional immune readouts for the confirmation of mendelian susceptibility to mycobacterial disease and related primary immunodeficiencies
(Stellenbosch : Stellenbosch University, 2019-04)Background: Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalence ... -
Surveillance of healthcare-associated infection in hospitalised South African children : Which method performs best?
(Health & Medical Publishing Group, 2017)Background. In 2012, the South African (SA) National Department of Health mandated surveillance of healthcare-associated infection (HAI), but made no recommendations of appropriate surveillance methods. Methods. Prospective ... -
Beta-lactam resistance mechanisms in Enterobacter species isolates from Tygerberg Hospital.
(Stellenbosch : Stellenbosch University, 2018-10-31)Background Resistance to carbapenem antibiotics in Gram-negative bacteria is a major public health problem due to limited treatment options. In Enterobacter species, carbapenemase production and reduced membrane permeability, ... -
Stool culture for diagnosis of pulmonary tuberculosis in children
(American Society for Microbiology, 2017-12)Bacteriological confirmation of Mycobacterium tuberculosis is achieved in the minority of young children with tuberculosis (TB), since specimen collection is resource intensive and respiratory secretions are mostly ... -
Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa : phenotypic and genotypic analysis of isolates
(BioMed Central, 2017-9)Background: Workers in clinical microbiology laboratories are exposed to a variety of pathogenic microorganisms. Salmonella species is among the most commonly reported bacterial causes of laboratory-acquired infections. ... -
Molecular detection of Mycobacterium tuberculosis in stool of children with suspected intrathoracic tuberculosis
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH SUMMARY: The bacteriological confirmation of tuberculosis in children is challenging. The current diagnostic gold standard, liquid culture of respiratory specimens, has low sensitivity in paucibacillary paediatric ... -
The epidemiology of Gram negative bacteraemia at Tygerberg Hospital
(Stellenbosch : Stellenbosch University, 2018-03)Background Escherichia coli and Klebsiella pneumoniae are common causes of Bloodstream Infections (BSI). β-lactam antibiotics, such as cephalosporins and carbapenems, are commonly used to treat these infections. Increasing ... -
First report of Wohlfahrtiimonas chitiniclastica bacteraemia in South Africa
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: No abstract available -
Plasmid-mediated mcr-1 colistin resistance in Escherichia coli and Klebsiella spp. clinical isolates from the Western Cape region of South Africa
(BioMed Central, 2017-08-03)Background: Colistin is a last resort antibiotic for the treatment of carbapenem-resistant Gram negative infections. Until recently, mechanisms of colistin resistance were limited to chromosomal mutations which confer a ... -
Rationale and design of the African group A streptococcal infection registry : the AFROStrep study
(BMJ Publishing Group, 2016)Introduction: Group A β-haemolytic Streptococcus (GAS), a Gram-positive bacterium, also known as Streptococcus pyogenes, causes pyoderma, pharyngitis and invasive disease. Repeated GAS infections may lead to autoimmune ... -
Characteristics and outcome of children with juvenile dermatomyositis in Cape Town: a cross-sectional study
(BioMed Central, 2016-11-11)Background: Juvenile dermatomyositis (JDM) is a rare idiopathic inflammatory childhood myopathy of uncertain aetiology. The demographic and clinical presentation of JDM may differ by race and geographic regions. Few ... -
Molecular characterization of Staphylococcus aureus isolates from various healthcare institutions in Nairobi, Kenya : a cross sectional study
(BioMed Central, 2016-09-20)Background: Staphylococcus aureus (S. aureus) has established itself over the years as a major cause of morbidity and mortality both within the community and in healthcare settings. Methicillin resistant S. aureus (MRSA) ... -
Genotypic and epidemiological characterization of Methicillin resistant Staphylococcus aureus (MRSA) and Coagulase Negative Staphylococcal (CoNS) strains isolated at Tygerberg Hospital
(Stellenbosch : Stellenbosch University, 2016-12)Background The global burden of methicillin resistant Staphylococcus aureus (MRSA) can be largely attributed to S. aureus’ ability to acquire the resistance element, SCCmec (Staphylococcal chromosome complex mec). ... -
The molecular epidemiology of pneumocystis jirovecii in Cape Town, South Africa
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : Pneumocystis jirovecii is an opportunistic fungal pathogen that causes Pneumocystis pneumonia (PCP) in immunocompromized hosts. PCP is associated with substantial morbidity, and mortality rates range ...
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