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Chemical Pathology
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Pioneering BRCA1/2 Point-Of-Care Testing for Integration of Germline and Tumor Genetics in Breast Cancer Risk Management: A Vision for the Future of Translational Pharmacogenomics
(Frontiers Media S.A, 2021-09)Research performed in South African (SA) breast, ovarian and prostate cancer patients resulted in the development of a rapid BRCA point-of-care (POC) assay designed as a time- and cost-effective alternative to laboratory-based ... -
Establishing Ghanaian adult reference intervals for hematological parameters controlling for latent anemia and inflammation
(Wiley, 2020-09)Background: In Ghana, diagnostic laboratories rely on reference intervals (RIs) provided by manufacturers of laboratory analyzers which may not be appropriate. This study aimed to establish RIs for hematological ... -
Circulating miR-30a-5p and miR-182-5p in prediabetes and screen-detected diabetes mellitus
(Dove Press, 2020-12)Background: microRNAs (miRNAs) have been touted as potential diagnostic and prognostic biomarkers for various diseases. The aim of the present study was to evaluate the diagnostic value of miR-30a-5p and miR-182-5p for ... -
Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2)
(BMJ Publishing Group Ltd & Association of Clinical Pathologists, 2021-04)The renin–angiotensin system is mainly associated with the regulation of blood pressure, but recently many other functions of this system have been described. ACE2, an 805-amino acid monocarboxypeptidase type I transmembrane ... -
Assessment of the association of plant- based diets with cardiovascular disease risk profile in Africa: a systematic review and meta-analysis protocol
(BMJ Publishing, 2020-06)Introduction Cardiovascular disease (CVD) is currently the leading cause of death worldwide. In Africa where infectious diseases are still the leading cause of death, the contribution of non-communicable diseases led by ... -
A method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser for the determination of potassium concentrations during hyperkalaemia in patients with kidney disease
(2020-07)Introduction: Hyperkalaemia is a common electrolyte disorder that may cause life-threatening cardiac arrythmias. We aimed to determine the agreement of potassium concentrations between GEM premier 3500 point-of-care blood ... -
Clinical staff knowledge and awareness of point of care testing best practices at Tygerberg Hospital, South Africa
(2020-07-16)Background: Point-of-care testing (POCT) is defined as testing done near or at the site of patient care with the goal of providing rapid information and improving patient outcomes. Point-of-care testing has many advantages ... -
Increase in blood pressure over a 7-year period in a mixed-ancestry South African population
(Health & Medical Publishing Group, 2019)Background. An increase in the prevalence of high blood pressure (BP) has been reported globally and in the South African (SA) population. Objectives. To investigate temporal changes in absolute BP levels and hypertension ... -
Case report : an index of suspicion in hyponatraemia
(Hrvatsko društvo za medicinsku biokemiju, 2019)Serum indices can give valuable information and should be interpreted as a result. Lipaemia can influence results through different mechanisms, an important one being the electrolyte exclusion effect. A case of pseudohyponatraemia ... -
Effect of model updating strategies on the performance of prevalent diabetes risk prediction models in a mixed-ancestry population of South Africa
(Public Library of Science, 2019-02-07)Background: Prediction model updating methods are aimed at improving the prediction performance of a model in a new setting. This study sought to critically assess the impact of updating techniques when applying existent ... -
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Leucocyte telomere length and glucose tolerance status in mixed-ancestry South Africans
(MDPI, 2019)ENGLISH ABSTRACT: Telomeres are DNA-tandem repeats situated at the ends of chromosomes and are responsible for genome stabilization. They are eroded by increased cell division, age and oxidative stress with shortened ... -
The impact of COVID-19 on routine patient care from a laboratory perspective
(Health & Medical Publishing Group, 2020-11-05)Background. Globally, few studies have examined the effect of the COVID-19 pandemic on routine patient care and follow-up. Objectives. To evaluate the effect of the COVID-19 response on biochemical test requests received ... -
Reference intervals for common chemistry and haematology laboratory tests in a healthy Kenyan population: variation with age, sex, BMI and comparison with a South African
(2020-12)ENGLISH ABSTRACT: Introduction Laboratory results play an important role in assessment of one’s health status including detection of sub-clinical disease. Reference intervals (RIs) have been shown to vary across different ... -
An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa
(AOSIS, 2020-04-30)Background: Burkitt lymphoma(BL) is a high grade non-Hodgkin lymphoma, which may be underdiagnosed in South Africa, due to a high burden of infectious diseases such as HIV and TB which may present with similar clinical ... -
Coronavirus disease 2019 (COVID-19) and the reninangiotensin system : a closer look at angiotensin-converting enzyme 2 (ACE2)
(Sage, 2020-05-01)ENGLISH ABSTRACT: Since the first cases of atypical pneumonia linked to the Huanan Seafood Wholesale Market in Wuhan, China were described in late December 2019, the global landscape has changed radically. In March 2020, ... -
Investigation of the role of vitamin D metabolism in South African breast cancer patients using a pathology-supported genetic testing platform
(Stellenbosch : Stellenbosch University., 2020-03)ENGLISH ABSTRACT: The high global breast cancer incidence drives the development of novel genomic approaches for disease prevention and targeted treatment. Towards this goal, a pathology-supported genetic testing (PSGT) ... -
The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease : a cross-sectional study
(BMC (part of Springer Nature), 2020-01-30)Background: To assess whether the agreement between fasting glucose and glycated proteins is affected by chronic kidney disease (CKD) in a community-based sample of 1621 mixed-ancestry South Africans. Methods: CKD was ... -
The discriminatory power of visceral adipose tissue area vs anthropometric measures as a diagnostic marker for metabolic syndrome in South African women
(BMC (part of Springer Nature), 2019-11-08)Background: A number of studies have shown central adiposity, in particular visceral adipose tissue (VAT) accumulation to be a hallmark of metabolic syndrome (MetS). In clinical practice, waist circumference (WC) is used ... -
Haematological profile of chronic kidney disease in a mixed-ancestry South African population : a crosssectional study
(BMJ Publishing Group, 2018-11)Objectives The objectives were to characterise the haematological profile of screen-detected chronic kidney disease (CKD) participants and to correlate the complete blood count measures with the commonly advocated kidney ...
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