Chemical Pathology
Collections in this community
Recent Submissions
-
A method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser for the determination of potassium concentrations during hyperkalaemia in patients with kidney disease
(2020-07)Introduction: Hyperkalaemia is a common electrolyte disorder that may cause life-threatening cardiac arrythmias. We aimed to determine the agreement of potassium concentrations between GEM premier 3500 point-of-care blood ... -
Clinical staff knowledge and awareness of point of care testing best practices at Tygerberg Hospital, South Africa
(2020-07-16)Background: Point-of-care testing (POCT) is defined as testing done near or at the site of patient care with the goal of providing rapid information and improving patient outcomes. Point-of-care testing has many advantages ... -
Increase in blood pressure over a 7-year period in a mixed-ancestry South African population
(Health & Medical Publishing Group, 2019)Background. An increase in the prevalence of high blood pressure (BP) has been reported globally and in the South African (SA) population. Objectives. To investigate temporal changes in absolute BP levels and hypertension ... -
Effect of model updating strategies on the performance of prevalent diabetes risk prediction models in a mixed-ancestry population of South Africa
(Public Library of Science, 2019-02-07)Background: Prediction model updating methods are aimed at improving the prediction performance of a model in a new setting. This study sought to critically assess the impact of updating techniques when applying existent ... -
-
Leucocyte telomere length and glucose tolerance status in mixed-ancestry South Africans
(MDPI, 2019)ENGLISH ABSTRACT: Telomeres are DNA-tandem repeats situated at the ends of chromosomes and are responsible for genome stabilization. They are eroded by increased cell division, age and oxidative stress with shortened ... -
The impact of COVID-19 on routine patient care from a laboratory perspective
(Health & Medical Publishing Group, 2020-11-05)Background. Globally, few studies have examined the effect of the COVID-19 pandemic on routine patient care and follow-up. Objectives. To evaluate the effect of the COVID-19 response on biochemical test requests received ... -
An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa
(AOSIS, 2020-04-30)Background: Burkitt lymphoma(BL) is a high grade non-Hodgkin lymphoma, which may be underdiagnosed in South Africa, due to a high burden of infectious diseases such as HIV and TB which may present with similar clinical ... -
Coronavirus disease 2019 (COVID-19) and the reninangiotensin system : a closer look at angiotensin-converting enzyme 2 (ACE2)
(Sage, 2020-05-01)ENGLISH ABSTRACT: Since the first cases of atypical pneumonia linked to the Huanan Seafood Wholesale Market in Wuhan, China were described in late December 2019, the global landscape has changed radically. In March 2020, ... -
Investigation of the role of vitamin D metabolism in South African breast cancer patients using a pathology-supported genetic testing platform
(Stellenbosch : Stellenbosch University., 2020-03)ENGLISH ABSTRACT: The high global breast cancer incidence drives the development of novel genomic approaches for disease prevention and targeted treatment. Towards this goal, a pathology-supported genetic testing (PSGT) ... -
The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease : a cross-sectional study
(BMC (part of Springer Nature), 2020-01-30)Background: To assess whether the agreement between fasting glucose and glycated proteins is affected by chronic kidney disease (CKD) in a community-based sample of 1621 mixed-ancestry South Africans. Methods: CKD was ... -
The discriminatory power of visceral adipose tissue area vs anthropometric measures as a diagnostic marker for metabolic syndrome in South African women
(BMC (part of Springer Nature), 2019-11-08)Background: A number of studies have shown central adiposity, in particular visceral adipose tissue (VAT) accumulation to be a hallmark of metabolic syndrome (MetS). In clinical practice, waist circumference (WC) is used ... -
Haematological profile of chronic kidney disease in a mixed-ancestry South African population : a crosssectional study
(BMJ Publishing Group, 2018-11)Objectives The objectives were to characterise the haematological profile of screen-detected chronic kidney disease (CKD) participants and to correlate the complete blood count measures with the commonly advocated kidney ... -
Electrophoresis test prevalence, requesting patterns, yield and related bone marrow biopsy findings at a South African tertiary hospital : a 5-year retrospective audit
(Health and Medical Publishing Group, 2017)Background. Studies of electrophoresis testing (serum protein electrophoresis (SPE), urine protein electrophoresis (UPE), immunofixation electrophoresis (IFE)) in a South African (SA) pathology laboratory setting are ... -
The association between vitamin D, vitamin D Binding proteins and VDR polymorphisms in diabetic and non-diabetic patients
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Introduction: Type 2 diabetes mellitus (T2DM) is by far the most prevalent form of diabetes manifesting with insulin resistance (IR), abnormal pancreatic β-cell function and hyperglycaemia. Evidence from ... -
Platelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individuals
(Nature Research, 2017)Platelet activation has been described in patients with chronic inflammation, however in type 2 diabetes mellitus it remains controversial. We compared levels of platelet leucocyte aggregates, monocyte and granulocyte ... -
The effect of fructosamine 3 kinase (FN3K) genotypes on the glycation gap in type 2 diabetic and non-diabetic mixed ancestry population of South Africa
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Introduction In2017 the International Diabetes Federation (IDF) reported that approximately 425 million adults aged 20-79 years were estimated to have diabetes mellitus (DM) worldwide. The nonenzymatic ... -
Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans : a cross sectional study
(BioMed Central, 2017-12-20)Background: Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease ... -
Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study)
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT : Chronic kidney disease (CKD) is described as abnormal kidney function in which one third is lost over a period of 3 months and is a global epidemic with a particularly concentrated incidence within ... -
Application of advanced molecular technology in the diagnosis and management of genetic disorders in South Africa
(Health & Medical Publishing Group, 2016)Background. Genetic testing has evolved from a niche speciality for diagnosis of rare disorders and carrier screening to subtyping of complex medical conditions for targeted treatment. Genes causing monogenic disorders are ...
RSS 1.0