Chemical Pathology
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Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans : a cross sectional study
(BioMed Central, 2017-12-20)Background: Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease ... -
Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study)
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT : Chronic kidney disease (CKD) is described as abnormal kidney function in which one third is lost over a period of 3 months and is a global epidemic with a particularly concentrated incidence within ... -
Application of advanced molecular technology in the diagnosis and management of genetic disorders in South Africa
(Health & Medical Publishing Group, 2016)Background. Genetic testing has evolved from a niche speciality for diagnosis of rare disorders and carrier screening to subtyping of complex medical conditions for targeted treatment. Genes causing monogenic disorders are ... -
Effects of different missing data imputation techniques on the performance of undiagnosed diabetes risk prediction models in a mixed-ancestry population of South Africa
(Public Library of Science, 2016)Background: Imputation techniques used to handle missing data are based on the principle of replacement. It is widely advocated that multiple imputation is superior to other imputation methods, however studies have ... -
Genome-wide DNA methylation in mixed ancestry individuals with diabetes and prediabetes from South Africa
(Hindawi Publishing Corporation, 2016)Aims. To conduct a genome-wide DNA methylation in individuals with type 2 diabetes, individuals with prediabetes, and control mixed ancestry individuals from South Africa. Methods. We used peripheral blood to perform ... -
A century of trends in adult human height
(eLife Sciences Publications, 2016)ENGLISH SUMMARY : Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to ... -
Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa : a cross-sectional study
(BioMed Central, 2017-07-17)Background: Factors influencing the increasing prevalence of overweight/obesity among children and adolescents in sub-Saharan Africa remain unclear. We assessed the prevalence and determinants of overweight and obesity and ... -
Metabolic syndrome and its predictors in an urban population in Kenya : a cross sectional study
(BioMed Central, 2017-07-04)Abstract Background The metabolic syndrome (MetS) is a clustering of interrelated risk factors which doubles the risk of cardio-vascular disease (CVD) in 5–10 years and ... -
Glucose tolerance, MTHFR C677T and NOS3 G894T polymorphisms, and global DNA methylation in mixed ancestry African individuals
(Hindawi, 2016-08-14)ENGLISH ABSTRACT: The aim of this study is to quantify global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South ... -
High molecular weight adiponectin levels are neither influenced by adiponectin polymorphisms nor associated with insulin resistance in mixed-ancestry hyperglycemic subjects from South Africa
(De Gruyter Open, 2016)Background: High molecular weight (HMW) adiponectin has antiatherogenic, antiinflammatory and antidiabetic properties and these effects have been linked to its effect on high density lipoprotein cholesterol (HDL-c). Single ... -
Methodological issues around the validation of models for predicting diabetes risk in developing countries
(Stellenbosch : Stellenbosh University, 2016-12)ENGLISH SUMMARY: Background: Multivariable diabetes risk prediction models have the potential to contribute to screening strategies, combining several risk factors to predict undiagnosed diabetes or future risk of developing ... -
HbA1c as a screening tool for diabetes mellitus and its use with traditional and novel biochemical parameters to predict cardiovascular risk in a local urban community
(Stellenbosch : Stellenbosh University, 2016-12)ENGLISH SUMMARY: Introduction The global obesity pandemic has reached Africa and the diabetes mellitus (DM) prevalence is increasing in parallel. A high prevalence of DM and risk for cardiovascular disease (CVD) has ... -
Paraoxonase 1 genetic polymorphisms in a mixed ancestry African population
(Hindawi Publishing Corporation, 2014-11-16)Paraoxonase 1 (PON1) activity is markedly influenced by coding polymorphisms, Q/R at position 192 and M/L at position 55 of the PON1 gene. We investigated the frequencies of these polymorphisms and their effects on PON1 ... -
Indices of paraoxonase and oxidative status do not enhance the prediction of subclinical cardiovascular disease in mixed-ancestry South Africans
(Hindawi Publishing Corporation, 2014-03-27)We evaluated the association of indices of paraoxonase (PON1) and oxidative status with subclinical cardiovascular disease (CVD) in mixed-ancestry South Africans. Participantswere 491 adults (126 men)whowere stratified by ... -
Molecular investigation of genetic factors associated with insulin resistance and obesity in a South African population
(Stellenbosch : Stellenbosh University, 2015-12)ENGLISH ABSTRACT: Background: The aetiopathogenesis of type 2 diabetes and the associated insulin resistance have been shown to have a strong genetic basis. Several genetic variants of the peroxisome proliferatoractivat ... -
Distribution and association of hs-CRP with cardiovascular risk variables of metabolic syndrome in adolescent learners
(AOSIS Publishing, 2012-06)Objective: Metabolic syndrome (MetS) and its associated cardiovascular risk are on the increase in children. High-sensitivity C-reactive protein (hs-CRP) has emerged as a useful marker for inflammation associated with ... -
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa
(BioMed Central, 2014-01)Background: The peroxisome proliferator-activated receptor gamma (PPARG), Pro12Ala and the insulin receptor substrate (IRS1), Gly972Arg confer opposite effects on insulin resistance and type 2 diabetes mellitus (T2DM). We ... -
Optimal waist-to-height ratio values for cardiometabolic risk screening in an ethnically diverse sample of South African urban and rural school boys and girls
(PLoS, 2013-08-13)Background The proposed waist-to-height ratio (WHtR) cut-off of 0.5 is less optimal for cardiometabolic risk screening in children in many settings. The purpose of this study was to determine the optimal WHtR for children ... -
The development and application of a polymerase chain reaction (PCR) based assay to determine the impact of genetic variation in South African patients diagnosed with depression
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Major Depressive Disorder (MDD) is a severe debilitating medical condition that may lead to suicide. Due to a poor understanding of the biological mechanisms underlying the disease process therapeutic ... -
Analysis of single nucleotide polymorphisms with opposite effects on serum iron parameters in South African patients with multiple sclerosis
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: There is growing interest in how genetic and environmental risk factors interact to confer risk for dysregulated iron homeostasis, which is considered a possible pathogenic mechanism in multiple sclerosis ...
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