Bacteremia in human immunodeficiency virus-infected children in Cape Town, South Africa

Le Roux D.M. ; Cotton M.F. ; Le Roux S.M. ; Whitelaw A. ; Lombard C.J. ; Zar H.J. (2011)


Bacteremia contributes to morbidity of HIV-infected children. In a randomized controlled trial evaluating trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis, 47 bacteremias were detected. The incidence rate of bacteremia increased in the first 3 months after starting combination antiretroviral therapy (cART), but decreased by 74% once children were established on cART for more than 3 months. Children should be prioritized for early cART. Copyright © 2011 by Lippincott Williams & Wilkins.

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