Department of Obstetrics and Gynaecology
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A case series of post-partum haemorrhage managed using Ellavi uterine balloon tamponade in a rural regional hospital
(AOSIS, 2021-05)Uterine balloon tamponade (UBT) should be attempted once emergency measures have been applied and medical treatment for post-partum haemorrhage (PPH) resulting from an atonic uterus has failed. Sinapi Biomedical (Pty) Ltd ... -
Using a composite maternal-infant outcome measure in tuberculosis prevention studies among pregnant women
(Oxford University Press, 2021-08-02)Background: Tuberculosis (TB-)-preventive therapy (TPT) among pregnant women reduces risk of TB in mothers and infants, but timing of initiation should consider potential adverse effects. We propose an analytical approach ... -
Pregnancy outcomes of women conceiving on antiretroviral therapy (ART) compared to those commenced on ART during pregnancy
(Oxford University Press, 2021-07)Background: Globally, the number of infected women of childbearing age living with human immunodeficiency virus (HIV) and conceiving on antiretroviral therapy (ART) is increasing. Evidence of ART safety at conception and ... -
Individual and composite adverse pregnancy outcomes in a randomized trial on isoniazid preventative therapy among women living with human immunodeficiency virus
(Oxford University Press, 2021-06-01)Background: International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1078, a randomized noninferiority study designed to compare the safety of starting isoniazid preventive therapy (IPT) in women living ... -
Effects of pregnancy and isoniazid preventive therapy on mycobacterium tuberculosis interferon gamma response assays in women with HIV
(Oxford University Press, 2020-07)Background Pregnancy is accompanied by immune suppression. We hypothesized that Mycobacterium tuberculosis-specific inflammatory responses used to identify latent tuberculosis infection (LTBI) lose positivity during ... -
Transitional objects of grief
(Comprensive Psychiatry, 2020-01)Background: Transitional objects provide security and symbolic connection with valued others when separated from them. Bereaved parents often keep, cherish and visit saved objects of their deceased child. This research ... -
Human oocyte and ovarian tissue vitrification in fertility preservation for women: an audit and prospective study
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH SUMMARY: Introduction: Female fertility preservation [FP] is of interest, due to the advancement in cancer therapy and the resultant increased survival rate. Methods of FP include embryo vitrification, oocyte ... -
Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage
(John Wiley & Sons, 2020)Objective: To assess the additional value of fetal multiplanar (axial, coronal and sagittal) neurosonography and magnetic resonance imaging (MRI) to that of the standard axial ultrasound planes in diagnosing brain damage ... -
INTERGROWTH-21st v. local South African growth standards (Theron-Thompson) for identification of small-for-gestational-age fetuses in stillbirths : a closer look at variation across pregnancy
(Health & Medical Publishing Group, 2019)Background. Global growth standards for fetuses were recently developed (INTERGROWTH-21st). It has been advocated that professional bodies should adopt these global standards. Objectives. To compare the ability of ... -
Evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia
(MDPI, 2021-11-05)ENGLISH ABSTRACT: Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of ... -
Neural tube defect diagnosis and outcomes at a tertiary South African hospital with intensive case ascertainment
(Health & Medical Publishing Group, 2019)Background. Neural tube defects (NTDs) are an important category of birth defect, but surveillance remains inadequate in South Africa. Objectives. To assess the identification of NTDs at a tertiary hospital using a range ... -
Endometrial cancer in young women. A retrospective matched cohort study.
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: OBJECTIVE: Endometrial cancer is the second most common gynaecological cancer in South Africa. It typically arises in the sixth and seventh decades of life. However, an increasing number of premenopausal ... -
Early onset pre-eclampsia with severe features necessitating fetal delivery: outcome of pregnancies with birthweight 1000-1800g at Tygerberg Hospital 2017
(Stellenbosch : Stellenbosch University, 2021-12)Introduction: Expectant management of early onset pre-eclampsia (EOPE) is an established practice at Tygerberg Hospital and some other tertiary institutions in South Africa. Its outcome has been documented in several ... -
Outcomes of assisted reproductive technologies in women 40 years and older at Tygerberg Hospital
(Stellenbosch : Stellenbosch University, 2021-12)Objective: To evaluate the outcomes of ART in women age of 40 years and above Design: Retrospective descriptive study Setting: Tygerberg Academic Hospital, Reproductive Medicine Unit Population: All women aged 40 years ... -
Pain management protocol for oocyte retrieval in low-resource setting assisted reproductive technology: Patient survey
(Stellenbosch : Stellenbosch University, 2021-12)Introduction: Assisted reproductive technology (ART) involves a series of procedures, the cost of which may prevent many from achieving reproduction desire s. To cut on the cost , oocyte retrieval has evolved into an ... -
Audit of term elective caesarean section outcomes at Tygerberg Academic Hospital
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Aim The aim of this study was to determine the proportion of patients intended for elective caesarean section (ELCS) at 39+0 weeks who are converted to emergency caesarean sections (EMCS) or normal ... -
Uptake rate of prenatal genetic screening and invasive testing in pregnant women over the age of 37 in Tygerberg Hospital and factors influencing this.
(2021-12)Introduction Prenatal screening in pregnant women of advanced maternal age has been shown to be ineffective in Cape Town. This study aims to determine the uptake rate of prenatal screening and invasive testing by ... -
Slow acceptance of universal antiretroviral therapy (ART) among mothers enrolled in IMPAACT PROMISE studies across the globe
(Springer, 2019)ENGLISH ABSTRACT: The PROMISE trial enrolled asymptomatic HIV-infected pregnant and postpartum women not eligible for antiretroviral treatment (ART) per local guidelines and randomly assigned proven antiretroviral strategies ... -
Bone involvement in patients with cervical carcinoma : a single-institution cohort study
(Taylor & Francis, 2019-12-13)Introduction: Bony metastases in cervical carcinoma are rare; however, autopsy studies indicate that they are underdiagnosed. A retrospective study was undertaken to describe the risk factors and tumour characteristics and ... -
Stillbirth risk across pregnancy by size for gestational age in Western Cape Province, South Africa : application of the fetuses-at-risk approach using perinatal audit data
(South African Medical Association, 2019-11-27)Background: There is little published work on the risk of stillbirth across pregnancy for small-for-gestational-age (SGA) and large-for-gestational (LGA) pregnancies in low-resource settings. Objectives: To compare ...
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