General Internal Medicine
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Effect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in research collaboration
(2020-12)In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), ... -
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation
(Nature Research (part of Springer Nature), 2019-02-28)Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid ... -
Management of lymphoma in a centre with high HIV and tuberculosis prevalence
(Stellenbosch : Stellenbosch University, 2021-12)Background The staging and management of patients with lymphoma (PWL) can be challenging and is particularly so in environments of high HIV and TB prevalence such as South Africa, for which there is little guidance. The ... -
miRNA signature of healthy vs impaired mesenchymal stem cells as a biomarker for autologous stem cell therapy
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Background: Globally, approximately 463 million adults are living with diabetes. This growing prevalence of diabetes places an increased burden on the health systems of low-to-middle income countries such ... -
Post-tuberculosis health-related quality of life, lung function and exercise capacity in a cured pulmonary tuberculosis population in the Breede Valley District, South Africa
(AOSIS, 2019)Background: Pulmonary tuberculosis (PTB) remains a major concern worldwide. Albeit curable, PTB continues to negatively affect patients’ health-related quality of life (HRQoL) and functioning even after cure. Objectives: To ... -
Reconceptualising health professions education in South Africa
(Academy of Science of South Africa, 2018)No abstract available. -
An investigation into the effects of ex vivo antioxidant treatment on the regenerative potential of mesenchymal stem cells following prolonged exposure to a pathological microenvironment associated with diabetes mellitus in vivo
(Stellenbosch -- Stellenbosch University., 2019-12)ENGLISH ABSTRACT: Obesity-associated type-2 diabetes mellitus (T2DM) is a multifactorial disease that causes severe comorbidities such as non-healing wounds. Non-healing diabetic wounds affect 15-25% of all diabetic patients ... -
Hereditary angio-oedema in the Western Cape Province, South Africa
(Health & Medical Publishing Group, 2018-03-28)Background. Hereditary angio-oedema (HAE) is an autosomal dominant condition caused by a deficiency in the C1-esterase inhibitor protein, resulting in increased bradykinin release. It presents clinically with recurrent ... -
Seasonal variations in tuberculosis diagnosis among HIV-positive individuals in Southern Africa : analysis of cohort studies at antiretroviral treatment programmes
(BMJ Publishing Group, 2018-01)Objectives Seasonal variations in tuberculosis diagnoses have been attributed to seasonal climatic changes and indoor crowding during colder winter months. We investigated trends in pulmonary tuberculosis (PTB) diagnosis ... -
South African guideline on deep brain stimulation for Parkinson’s disease
(Health & Medical Publishing Group, 2017)Background. Parkinson’s disease (PD) is a common neurodegenerative disease, associated with severe impairment of quality of life. Although the motor aspects of the illness are typically successfully treated with medications ... -
A retrospective study evaluating the efficacy of identification and management of sepsis at a district-level hospital internal medicine department in the Western Cape Province, South Africa, in comparison with the guidelines stipulated in the 2012 Surviving Sepsis Campaign
(Health & Medical Publishing Group, 2017)Background. Currently there is little information on the identification, management and outcomes of patients with sepsis in developing countries. Simple cost-effective measures such as accurate identification of patients ... -
A refined multiscale self-entropy approach for the assessment of cardiac control complexity : application to long QT syndrome type 1 patients
(MDPI, 2015-11-13)ENGLISH ABSTRACT: The study proposes the contemporaneous assessment of conditional entropy (CE) and self-entropy (sE), being the two terms of the Shannon entropy (ShE) decomposition, as a function of the time scale via ... -
Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial
(BioMed Central, 2016)Background: The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin ... -
The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: Diseases resulting from the dysregulation of adipocyte and osteoblast differentiation include diabetes type II and osteoporosis. Both adipocytes and osteoblasts are derived from the same progenitor cell ... -
Low-Pass filtering approach via empirical mode decomposition improves short-scale entropy-based complexity estimation of QT interval variability in long QT syndrome type 1 patients
(MDPI, 2014-09-05)Entropy-based complexity of cardiovascular variability at short time scales is largely dependent on the noise and/or action of neural circuits operating at high frequencies. This study proposes a technique for canceling ... -
Development and usability evaluation of a multimedia e-learning resource for electrolyte and acid-base disorders
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: We have developed an innovative multimedia e-learning resource, the Electrolyte Workshop, to provide students and clinicians with instruction and the opportunity for simulated practice in managing ... -
A historical perspective of allogeneic and autologous immunohaematopoietic stem cell transplantation in South Africa and a study of the non-haematologic consequences
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: HISTORICAL PERSPECTIVE Stem cell therapy was commenced after using rabbits as research models. Once this process was successful, the first human transplant was done in 1974. Certain prerequisites were ... -
South African renal registry annual report 2012
(South African Renal Society, 2012-04)INTRODUCTION: This first report of the new South African Renal Registry provides data on renal replacement therapy (RRT) for patients with end-stage renal disease (ESRD) in South Africa. Our previous registry, the ... -
The effect of highly active antiretroviral therapy on Human Papilloma Virus Infection and Cervical Dysplasia in women living with HIV
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Title The Effect of Highly Active Antiretroviral Therapy on Human Papilloma Virus Infection and Cervical Cytological Abnormalities in Women Living With HIV Background Human Papillomavirus (HPV) infection ... -
A longitudinal study of the stability of the dentition following orthodontic treatment
(Stellenbosch : Stellenbosch University, 1992)ENGLISH ABSTRACT: The maintenance of dental alignment following orthodontic treatment has been, and continues to be, a challenge for the orthodontist (McReynolds and Little, 1991). Orthodontists should endeavour to ...
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