Department of Medicine
Sub-communities within this community
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Cardiology [40]
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Dermatology [6]
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Endocrinology [4]
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Gastroenterology [2]
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General Medicine [17]
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Infectious Diseases [18]
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Nephrology [19]
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Neurology [10]
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Pulmonology [20]
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Rheumatology [2]
Recent Submissions
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South African guideline on deep brain stimulation for Parkinson’s disease
(Health & Medical Publishing Group, 2017)Background. Parkinson’s disease (PD) is a common neurodegenerative disease, associated with severe impairment of quality of life. Although the motor aspects of the illness are typically successfully treated with medications ... -
EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy
(Elsevier, 2017-09)ENGLISH ABSTRACT: the presurgical evaluation of epilepsy as a reflection of the irritative zone. ESI of ictal scalp EEG to localize the seizure onset zone (SOZ) remains challenging. We investigated the value of an approach ... -
Twelve-year mortality in adults initiating antiretroviral therapy in South Africa
(Wiley Open Access, 2018)Introduction: South Africa has the largest number of individuals living with HIV and the largest antiretroviral therapy (ART) programme worldwide. In September 2016, ART eligibility was extended to all 7.1 million ... -
HIV viral load as an independent risk factor for tuberculosis in South Africa : collaborative analysis of cohort studies
(Wiley Open Access, 2017)Introduction: Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV replication as a risk ... -
Advancing global health through cardiovascular research, mentorship, and capacity building : in memoriam, professor Bongani Mayosi (1967–2018)
(BMC (part of Springer Nature), 2018-10-03)ENGLISH ABSTRACT: No abstract available -
A retrospective audit of mitral valve repair surgery at Tygerberg Hospital
(South African Heart Association, 2018)Background: Mitral valve repair is well established as the preferred treatment modality for the majority of patients with degenerative mitral valve disease requiring intervention. Valve repair offers a distinct event-free ... -
Speckle tracking echocardiography in acute lupus myocarditis : comparison to conventional echocardiography
(BioScientifica, 2017)Aims: Lupus myocarditis occurs in 5–10% of patients with systemic lupus erythematosus (SLE). No single feature is diagnostic of lupus myocarditis. Speckle tracking echocardiography (STE) can detect subclinical left ... -
A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
(BioScientifica, 2017)The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid ... -
Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab
(University of California, 2017)PASH syndrome (pyoderma gangrenosum, acne, and suppurative hidradenitis) forms part of the spectrum of autoinflammatory diseases. We report an unusual case of PASH syndrome in a patient with end-stagerenal disease (ESRD) ... -
Screening for rheumatic heart disease : is a paradigm shift required?
(BioScientifica, 2017)This focused review presents a critical appraisal of the World Heart Federation criteria for the echocardiographic diagnosis of rheumatic heart disease (RHD) and its performance in African RHD screening programmes. It ... -
Shifting tasks from pharmacy to nonpharmacy personnel for providing antiretroviral therapy to people living with HIV : a systematic review and metaanalysis
(BMJ Publishing Group, 2017-8)Objectives Lay people or non-pharmacy health workers with training could dispense antiretroviral therapy (ART) in resource-constrained countries, freeing up time for pharmacists to focus on more technical tasks. ... -
Rheumatic heart disease screening : current concepts and challenges
(Medknow Publications, 2017)Rheumatic heart disease (RHD) is a disease of poverty, is almost entirely preventable, and is the most common cardiovascular disease worldwide in those under 25 years. RHD is caused by acute rheumatic fever (ARF) which ... -
A Validated stable HPLC method for the simultaneous determination of rifampicin and 25-O-desacetyl rifampicin – evaluation of in vitro metabolism
(Akademiai Kiado, 2017)A simple, efficient, and stable high-performance liquid chromatography (HPLC) separation method for a combination of rifampicin (RIF), its major metabolite 25-O-desacetyl rifampicin (25ODESRIF), and neostigmine (NEO) was ... -
Lipoatrophy/lipohypertrophy outcomes after antiretroviral therapy switch in children in the UK/Ireland
(Public Library of Science, 2017)Background: Following widespread use of stavudine, a thymidine analogue, in antiretroviral therapy (ART) over the past three decades, up to a third of children developed lipoatrophy (LA) and/or lipohypertrophy (LH). ... -
A refined multiscale self-entropy approach for the assessment of cardiac control complexity : application to long QT syndrome type 1 patients
(MDPI, 2015-11-13)ENGLISH ABSTRACT: The study proposes the contemporaneous assessment of conditional entropy (CE) and self-entropy (sE), being the two terms of the Shannon entropy (ShE) decomposition, as a function of the time scale via ... -
An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens : study protocol for a randomized controlled trial
(BioMed Central, 2017-11-25)Background: Current guidelines for treatment of multidrug-resistant tuberculosis (MDR-TB) are largely based on expert opinion and observational data. Fluoroquinolones remain an essential part of MDR-TB treatment, but ... -
Residual renal function in chronic dialysis is not associated with reduced erythropoietin-stimulating agent dose requirements : a cross-sectional study
(BioMed Central, 2017-11-25)Background: Anaemia is a very common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment. Residual renal function (RRF) is ... -
Prevention of infective endocarditis associated with dental interventions : South African Heart association position statement, endorsed by the South African Dental Association
(South African Heart Association, 2017)ENGLISH ABSTRACT: Infective endocarditis (IE) is associated with significant morbidity and mortality. Prevention is therefore an important clinical entity. The maintenance of optimal oral health is likely to play the most ... -
Strengthening renal registries and ESRD research in Africa
(Elsevier, 2017)ENGLISH ABSTRACT: In Africa the combination of non-communicable diseases, infectious diseases, exposure to environmental toxins and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic ... -
An overview of the biological disease modifying drugs available for arthritic conditions in South Africa
(Taylor & Francis, 2016)ENGLISH ABSTRACT: The past decade has seen a major change in the treatment options and strategies for rheumatoid arthritis (RA) and the other immune-mediated arthritic diseases. The disease modifying antirheumatic drugs ...
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