• An analysis of biopsies for suspected skin cancer at a tertiary care dermatology clinic in the Western Cape province of South Africa 

  De Wet, Johann; Steyn, Minette; Jordaan, Henry F.; Smith, Rhodine; Claasens, Saskya; Visser, Willem I. (Hindawi, 2020)

  Background. Skin cancer is a growing health concern worldwide. It is the most common malignancy in South Africa and places a large burden on the public healthcare sector. There is a paucity of published scientific data on ...
• Post-tuberculosis lung health : perspectives from the First International Symposium 

  Allwood, B. W.; van der Zalm, M. M.; Amaral, A. F. S.; Byrne, A.; Datta, S.; Egere, U.; Evans, C. A.; Evans, D.; Gray, D. M.; Hoddinott, G.; Ivanova, O.; Jones, R.; Makanda, G.; Marx, F. M.; Meghji, J.; Mpagama, S.; Pasipanodya, J. G.; Rachow, A.; Schoeman, I.; Shaw, J.; Stek, C.; van Kampen, S.; von Delft, D.; Walker, N. F.; Wallis, R. S.; Mortimer, K. (International Union Against Tuberculosis and Lung Disease, 2020-08-01)

  ALTHOUGH CURABLE, TB frequently leaves the individual with chronic physical and psycho-social impairment, but these consequences have been largely neglected. The 1st International Post-Tuberculosis Symposium (Stellenbosch, ...
• COVID-19 travel restrictions and the International Health Regulations – Call for an open debate on easing of travel restrictions 

  Petersen, Eskild; McCloskey, Brian; Hui, David S.; Kock, Richard; Ntoumi, Francine; Memish, Ziad A.; Kapata, Nathan; Azhar, Esam I.; Pollack, Marjorie; Madoff, Larry C.; Hamer, Davidson H.; Nachega, Jean B.; Pshenichnaya, N.; Zumla, Alimuddin (Elsevier, 2020-05)

  The COVID-19 pandemic caused by the novel coronavirus (SARS-CoV-2) has made national governments worldwide to mandate several generic infection control measures such as physical distancing, self-isolation, and closure of ...
• COVID-19 response in low- and middle-income countries : don’t overlook the role of mobile phone communication 

  Verhagen, Lilly M.; de Groot, R.; Lawrence, C. A.; Taljaard, J.; Cotton, M. F.; Rabie, H. (Elsevier, 2020-07-26)

  Estimates of health capacities in the context of the coronavirus disease 2019 (COVID-19) pandemic indicate that most low- and middle-income countries (LMICs) are not operationally ready to manage this health emergency. ...
• Transition from restrictive to obstructive lung function impairment during treatment and follow-up of active tuberculosis 

  Allwood, Brian W.; Maasdorp, Elizna; Kim, Grace J.; Cooper, Christopher B.; Goldin, Jonathan; van Zyl-Smit, Richard N.; Bateman, Eric D.; Dawson, Rodney (Dove Press, 2020-05)

  Background: Pulmonary tuberculosis (PTB) is associated with many forms of chronic lung disease including the development of chronic airflow obstruction (AFO). However, the nature, evolution and mechanisms responsible for ...
• Evidence to support the classification of hyperglycemia first detected in pregnancy to predict diabetes 6–12 weeks postpartum : a single center cohort study 

  Coetzee, Ankia; Sadhai, Nishendra; Mason, Deidre; Hall, David R.; Conradie, Magda (Elsevier, 2020-09)

  Aims: Diagnostic criteria for type 2 diabetes mellitus (T2DM) applied to women with gestational diabetes mellitus (GDM) may predict postpartum T2DM but requires validation. Methods: Women with GDM aged ≥ 18-years were ...
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  Xpert mycobacterium tuberculosis/rifampicin-detected rifampicin resistance is a suboptimal surrogate for multidrug-resistant tuberculosis in Eastern Democratic Republic of the Congo : diagnostic and clinical implications 

  Bisimwa, Bertin C.; Nachega, Jean B.; Warren, Robin M.; Theron, Grant; Metcalfe, John Z.; Shah, Maunank; Diacon, Andreas H.; Sam-Agudu, Nadia A.; Yotebieng, Marcel; Bulabula, André N. H.; Katoto, Patrick D. M. C.; Chirambiza, Jean-Paul; Nyota, Rosette; Birembano, Freddy M.; Musafiri, Eric M.; Byadunia, Sifa; Bahizire, Esto; Kaswa, Michel K.; Callens, Steven; Kashongwe, Zacharie M. (Oxford University Press, 2020-06)

  Background Rifampicin (RIF) resistance is highly correlated with isoniazid (INH) resistance and used as proxy for multidrug-resistant tuberculosis (MDR-TB). Using MTBDRplus as a comparator, we evaluated the predictive ...
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  The late arrival of coronavirus disease 2019 (COVID-19) in Africa : mitigating pan-continental spread 

  Nachega, Jean; Seydi, Moussa; Zumla, Alimuddin (Oxford University Press, 2020-07)

  The novel coronavirus disease 2019 (COVID-19) has rapidly spread to all 7 continents. Due to yet unknown reasons, the African continent has remained relatively unaffected. We discuss the importance of mitigating pan-continental ...
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  From easing lockdowns to scaling up community-based coronavirus disease 2019 screening, testing, and contact tracing in Africa-shared approaches, innovations, and challenges to minimize morbidity and mortality 

  Nachega, Jean B.; Grimwood, Ashraf; Mahomed, Hassan; Fatti, Geoffrey; Preiser, Wolfgang; Kallay, Oscar; Mbala, Placide K.; Muyembe, Jean-Jacques T.; Rwagasore, Edson; Nsanzimana, Sabin; Ngamije, Daniel; Condo, Jeanine; Sidat, Mohsin; Noormahomed, Emilia V.; Reid, Michael; Lukeni, Beatrice; Suleman, Fatima; Mteta, Alfred; Zumla, Alimuddin (Oxford University Press, 2020-05)

  The arrival of coronavirus disease 2019 (COVID-19) on the African continent resulted in a range of lockdown measures that curtailed the spread of the infection but caused economic hardship. African countries now face ...
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  Diverse Human Immunodeficiency Virus-1 Drug Resistance Profiles at Screening for ACTG A5288: A Study of People Experiencing Virologic Failure on Second-line Antiretroviral Therapy in Resource-limited Settings 

  Wallis, Carole L.; Hughes, Michael D.; Ritz, Justin; Viana, Raquel; de Jesus, Carlos Silva; Saravanan, Shanmugam; van Schalkwyk, Marije; Mngqibisa, Rosie; Salata, Robert; Mugyenyi, Peter; Hogg, Evelyn; Hovind, Laura; Wieclaw, Linda; Gross, Robert; Godfrey, Catherine; Collier, Ann C.; Grinsztejn, Beatriz; Mellors, John W. (Oxford University Press, 2020-10)

  Background: Human immunodeficiency virus (HIV) drug resistance profiles are needed to optimize individual patient management and to develop treatment guidelines. Resistance profiles are not well defined among individuals ...
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  Survival of South African patients on renal replacement therapy 

  Jardine, Thabiet; Wong, Esther; Steenkamp, Retha; Caskey, Fergus J.; Davids, Mogamat Razeen (European Renal Association - European Dialysis and Transplant Association (ERA-EDTA), 2020-10)

  Background The majority of South Africans rely on a resource-constrained public healthcare sector, where access to renal replacement therapy (RRT) is strictly rationed. The incidence of RRT in this sector is only 4.4 per ...
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  ‘Building on shaky ground’—challenges to and solutions for primary care guideline implementation in four provinces in South Africa : a qualitative study 

  Kredo, Tamara; Cooper, Sara; Abrams, Amber Louise; Muller, Jocelyn; Schmidt, Bey-Marrié; Volmink, Jimmy; Atkins, Salla (BMJ Publishing, 2020-05)

  Objectives Clinical guidelines support evidence-informed quality patient care. Our study explored perspectives of South African subnational health managers regarding barriers to and enablers for implementation for all ...
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  Effect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in research collaboration 

  Nachega, Jean B; Sam-Agudu, Nadia A; Budhram, Samantha (2020-12)

  In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), ...
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  Fourteen-Day Bactericidal Activity, Safety, and Pharmacokinetics of Linezolid in Adults with Drug-Sensitive Pulmonary Tuberculosis 

  Diacon, Andreas; De Jager, Veronique R; Dawson, Rodney (2020-01)

  Background: Linezolid is increasingly used for the treatment of tuberculosis resistant to first-line agents, but the most effective dosing strategy is yet unknown. Methods: Between November 2014 and November 2016, we ...
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  The South African SHARE-TAVI registry : incidence and risk factors leading to conduction disturbances requiring permanent pacemaker implantation 

  Du Toit, Rudolf; Doubell, Anton; Abelson, Mark; Hellig, Farrel; Horak, Adie; Mabin, Thomas; Klug, Eric; Schaafsma, Elizabeth; Van Wyk, Jacques; Scherman, Jacques; Ntsekhe, Mpiko; Weich, Hellmuth (South African Heart Association, 2021)

  Background: One of the most common complications post transcatheter aortic valve implantation (TAVI) is the development of heart block requiring permanent pacemaker implantation (PPM). The incidence of PPM in international ...
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  The hidden continuum of HIVassociated cardiomyopathy : a focussed review with case reports 

  Robbertse, Pieter-Paul; Doubell, Anton; Nachega, Jean; Herbst, Philip (South African Heart Association, 2021)

  ENGLISH ABSTRACT: HIV-associated cardiomyopathy (HIVAC) is a poorly understood group of diseases with a poor prognosis once ventricular dysfunction is present. Cardiovascular magnetic resonance has revealed a previously ...
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  Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation 

  Page, Martin J.; Thomson, Greig J. A.; Nunes, J. Massimo; Engelbrecht, Anna-Mart; Nell, Theo A.; De Villiers, Willem J. S.; De Beer, Maria C.; Engelbrecht, Lize; Kell, Douglas B.; Pretorius, Etheresia (Nature Research (part of Springer Nature), 2019-02-28)

  Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid ...
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  The state of kidney transplantation in South Africa 

  Moosa, M. R. (Health & Medical Publishing Group, 2019)

  Background. Kidney transplantation has been performed in South Africa (SA) since 1966. Transplants were initially limited to public hospitals, and the entry of the private sector heralded a new era in organ transplantati ...
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  Evaluation of factors and patterns influencing the 30-day readmission rate at a tertiary-level hospital in a resource-constrained setting in Cape Town, South Africa 

  Dreyer, R.; Viljoen, A. J. (Health & Medical Publishing Group, 2019)

  Background. Factors contributing to and causes of hospital readmissions have been investigated worldwide, but very few studies have been performed in South Africa (SA) and none in the Western Cape Province. Objectives. ...
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  The utility of hand-held mobile spirometer technology in a resource-constrained setting 

  Du Plessis, E.; Swart, F.; Maree, D.; Heydenreich, J.; Van Heerden, J.; Esterhuizen, T. M.; Irusen, E. M.; Koegelenberg, C. F. N. (Health & Medical Publishing Group, 2019)

  Background. Mobile phone-linked spirometry technology has been designed specifically for evaluating lung function at primary care level. The Air-Smart Spirometer is the first mobile spirometer accepted in Europe for the ...

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