Nuclear Medicine
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Evaluation of BCL-2 and PARP-1 as potential therapeutic targets to radiosensitise lung cancer
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH SUMMARY : Lung cancer remains the most incident malignancy worldwide, representing 13% of all cancers. It is also the leading cause of death in the world, accounting for 18 18.2% of global cancer-related deaths. ... -
Dual energy window imaging for optimisation of P/V ratios in VP SPECT
(SpringerOpen, 2021)Purpose: Ventilation–perfusion single-photon emission computed tomography (VP SPECT) plays an important role in pulmonary embolism diagnosis. Rapid results may be obtained using same-day ventilation followed by perfusion ... -
Semiquantitative analysis of FDG PET brain scans using Neurostat and SPM
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH SUMMARY : Background: Positron emission tomography using Fluorine-18 2-Fluoro-2-Deoxy-D-Glucose (FDG-PET) has an established role in the investigation of multiple neurological conditions such as neurolupus and ... -
Peptide receptor radionuclide therapy of neuroendocrine tumors : how important is internal dosimetry?
(Health and Medical Publishing Group, 2019)No abstract available -
Influence of acquisition time and smoothing parameters on Ga-68 wholebody PET/CT image quality
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH SUMMARY : PET/CT image optimization has been extensively investigated for 18F–FDG PET imaging. Although 68Ga–tracers are already widely used in PET, optimized imaging and reconstruction are still missing. The aim ... -
Optimization of production methods for gallium-68 PET radiopharmaceuticals in a hospital radiopharmacy
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH SUMMARY : Production of radiopharmaceuticals intended for human use and research purposes is generally performed in well-equipped commercial or research facilities that usually have access to advanced equipment for ... -
Implementation of guidelines on hospital radiopharmacy in low-income settings
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH SUMMARY : Although radiopharmacy is more than 50 years old, it is still in a stage of rapid development. This dissertation focuses on quality issues in radiopharmacies in developing countries. Guidelines for ... -
Validation of a cost-effective alternative for a radiochromatography method to be used in a developing country
(SpringerOpen (part of Springer Nature), 2020-04-10)Introduction: The radiochemical purity (RCP) of technetium-99m labelled radiopharmaceuticals (RP) is important to ensure optimal scintigraphic image quality. In low-income settings, it may not be possible to use compendial ... -
Methamphetamine dependence with and without psychotic symptoms : a multi-modal brain imaging study
(Elsevier, 2018)Objective: Methamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with ... -
Validation of equations to estimate glomerular filtration rate in South Africans of mixed ancestry
(Health & Medical Publishing Group, 2020-02-26)Background. The Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations are two commonly used formulae to estimate glomerular filtration rate (GFR) in adults. ... -
The College of Nuclear Physicians of South Africa practice guidelines on peptide receptor radionuclide therapy in neuroendocrine tumours
(Health and Medical Publishing Group, 2018)Background: Peptide receptor radionuclide therapy (PRRT) for metastatic or inoperable neuroendocrine tumours (NETs) is a systemic therapy which targets somatostatin receptors overexpressed by differentiated NETs for ... -
Glomerular filtration rate measurement and estimation : improvement and validation of existing methods
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH SUMMARY : Glomerular filtration rate (GFR) is regarded as the best measure of kidney function. It can either be measured or estimated. This dissertation aims to provide a better understanding of GFR measurement in ... -
Social anxiety disorder : Functional neuroimaging and social cognitive features
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH SUMMARY : Neuroimaging has enabled important progress in understanding the neurobiology of social anxiety disorder (SAD). Functional neuroimaging experiments in SAD have mostly focused on regional neural activity ... -
Investigation into various aspects of radiolabelling somatostatin peptide derivatives with 68Ga eluted from a SnO2-based 68Ge/68Ga generator
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH SUMMARY : 68Ge/68Ga generators ensure the supply of 68Ga for positron emission tomography (PET), for instance for somatostatin receptor imaging with 68Ga-DOTA-labelled somatostatin analogues. There are various ... -
Appropriate indications for positron emission tomography/computed tomography : College of Nuclear Physicians of the Colleges of Medicine of South Africa
(Health & Medical Publishing Group, 2016)Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment of response to treatment, which is made possible by positron emission tomography/computed ... -
An update on the management of breast cancer in Africa
(BioMed Central, 2017-02-14)ENGLISH SUMMARY : Background: There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the ... -
Monitoring various eluate characteristics of the iThemba LABS SnO2-based 68Ge/68Ga generator over time and validation of quality control methods for the radiochemical purity assessment of 68Ga-labelled DOTA peptide formulations
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY : PET imaging with gallium-68 (68Ga) has become widely used due to the availability of 68Ge/68Ga generators and DOTA-derivatised peptide ligands for radiolabelling. The purpose of this study was to monitor ... -
Evaluation of the effect of low and intermediate frequency electromagnetic waves on radiosensitivity
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH SUMMARY : The incidence of epidemic Kaposi’s sarcoma in HIV/AIDS patients is high due to their compromised immune system. HIV-positive individuals presenting with cancer tend to be more sensitive to ionizing radiation ... -
Evaluation of small molecule inhibitors of HER2, PI3K, mTOR and Bcl-2 for their radiomodulatory effects in human breast cancer cell lines
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH SUMMARY : Breast cancer remains the most commonly diagnosed cancer in women. It is responsible for 32% of all cancers and 15% of all cancer-related deaths in females. Patients with triple-negative breast ... -
Validation of radiochemical purity analysis methods used in two tertiary public hospitals in South Africa
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH SUMMARY : Radiopharmaceutical kits are supplied by manufacturers with package inserts containing information about the kit including validated methods of preparation and radiochemical purity (RCP) analysis. Validated ...
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