Research Articles (Stellenbosch Institute for Advanced Studies)
Recent Submissions
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Projected climatic and hydrologic changes to lake Victoria Basin Rivers under three RCP emission scenarios for 2015–2100 and impacts on the water sector
(MDPI, 2019)Rivers in the Lake Victoria Basin support a multitude of ecosystem services, and the economies of the riparian countries (Kenya, Tanzania, Uganda, Rwanda, and Burundi) rely on their discharge, but projections of their ... -
Mce3R stress-resistance pathway is vulnerable to small-molecule targeting that improves tuberculosis drug activities
(American Chemical Society, 2019)One-third of the world’s population carries Mycobacterium tuberculosis (Mtb), the infectious agent that causes tuberculosis (TB), and every 17 s someone dies of TB. After infection, Mtb can live dormant for decades in ... -
A continuous-time persistent random walk model for flocking
(AIP Publishing, 2018)A classical random walker is characterized by a random position and velocity. This sort of random walk was originally proposed by Einstein to model Brownian motion and to demonstrate the existence of atoms and molecules. ... -
They are my future : childbearing desires and motivations among women with disabilities in Ghana - implications for reproductive healthcare
(BMC, 2020-10-06)Background: Previous research has highlighted widespread public mis/perceptions that portray women with disabilities (WWDs) as asexual, less likely to marry, and often not interested in childbearing. However, evidence ... -
Effectiveness of the baby-friendly community initiative in promoting exclusive breastfeeding among HIV negative and positive mothers : a randomized controlled trial in Koibatek Sub-County, Baringo, Kenya
(BMC (part of Springer Nature), 2020-07-14)Background: Although the baby-friendly community initiative (BFCI) has been proposed as a community-level approach to improve infant feeding practices, there is little data on its variation in effectiveness by HIV status. ... -
An integrative network-driven pipeline for systematic identification of lncRNA-associated regulatory network motifs in metastatic melanoma
(BMC (part of Springer Nature), 2020-07-23)Background: Melanoma phenotype and the dynamics underlying its progression are determined by a complex interplay between different types of regulatory molecules. In particular, transcription factors (TFs), microRNAs ... -
COVID-19 Disease map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms
(Springer Nature, 2020)We announce the COVID-19 Disease Map (https://doi.org/10.17881/covid19-disease-map), an effort to build a comprehensive, standardized knowledge repository of SARS-CoV-2 virus-host interaction mechanisms, guided by input ... -
Causal cognition, force dynamics and early hunting technologies
(Frontiers Media, 2018)With this contribution we analyze ancient hunting technologies as one way to explore the development of causal cognition in the hominin lineage. Building on earlier work, we separate seven grades of causal thinking. By ... -
Understanding iron metabolism : lessons from transfusion-dependent Thalassemia
(Oman Medical Specialty Board, 2018)No abstract available -
Upscaling biodiversity : estimating the species–area relationship from small samples
(Ecological Society of America, 2018)The challenge of biodiversity upscaling, estimating the species richness of a large area from scattered local surveys within it, has attracted increasing interest in recent years, producing a wide range of competing ... -
Childhood obesity in urban Ghana : evidence from a cross-sectional survey of in-school children aged 5–16 years
(BMC (part of Springer Nature), 2019-11-26)Background: Childhood obesity is a growing public health concern in many low-income urban settings; but its determinants are not clear. The purpose of this study is to assess the prevalence of childhood obesity and associated ... -
Transfusion in Haemoglobinopathies : review and recommendations for local blood banks and transfusion services in Oman
(Sultan Qaboos University, 2018)Sickle cell disease and homozygous β-thalassaemia are common haemoglobinopathies in Oman, with many implications for local healthcare services. The transfusions of such patients take place in many hospitals throughout the ... -
Developmental origins of health and disease in Africa - influencing early life
(Elsevier, 2018)It is well established that Africa is undergoing rapid transitions resulting in a triple burden of malnutrition, infectious diseases, and non-communicable diseases (NCDs).1,2 That health systems are unlikely to be able to ... -
Diffusion markers of dendritic density and arborization in gray matter predict differences in intelligence
(Nature Research (part of Springer Nature), 2018)Previous research has demonstrated that individuals with higher intelligence are more likely to have larger gray matter volume in brain areas predominantly located in parieto-frontal regions. These findings were usually ... -
Two distance memories in desert ants - modes of interaction
(Public Library of Science, 2018-10-10)Navigation plays an essential role for many animals leading a mobile mode of life, and for central place foragers in particular. One important prerequisite for navigation is the ability to estimate distances covered during ... -
Competition between silicifiers and non-silicifiers in the past and present ocean and its evolutionary impacts
(Frontiers Media, 2018)Competition is a central part of the evolutionary process, and silicification is no exception: between biomineralized and non-biomineralized organisms, between siliceous and non-siliceous biomineralizing organisms, and ... -
Coupling, reinforcement, and speciation
(University of Chicago Press, 2018)During the process of speciation, populations may diverge for traits and at their underlying loci that contribute barriers to gene flow. These barrier traits and barrier loci underlie individual barrier effects, by which ... -
Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons
(The Company of Biologists, 2018-05-18)GFRα1, a receptor for glial cell line-derived neurotrophic factor (GDNF), is critical for the development of the main olfactory system. The olfactory bulb (OB) of Gfra1 knockout mice shows significant reductions in the ... -
Risky sexual behaviour and contraceptive use in contexts of displacement : insights from a cross-sectional survey of female adolescent refugees in Ghana
(BMC (part of Springer Nature), 2019-08-16)Background: Difficulty in accessing sexual and reproductive healthcare is one of the challenges young refugee women face worldwide, in addition to sexual exploitation, violence and abuse. Although Ghana hosts several ... -
Primary processing neuropils associated with the malleoli of camel spiders (Arachnida, Solifugae) : a re-evaluation of axonal pathways
(BMC (part of Springer Nature), 2019-08-02)Background - Arachnids possess highly specialized and unorthodox sense organs, such as the unique pectines of Scorpiones and the malleoli of Solifugae. While the external morphology, numbers, and shapes of sensory organs ...
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