Research Articles (Stellenbosch Institute for Advanced Studies)
Recent Submissions
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General criterion for harmonicity
(American Physical Society, 2017)Inspired by Kubo-Anderson Markov processes, we introduce a new class of transfer matrices whose largest eigenvalue is determined by a simple explicit algebraic equation. Applications include the free energy calculation for ... -
Review and recommendations on management of adult female thalassemia patients with hypogonadism based on literature review and experience of ICET-A network specialists
(PAGEpress, 2017)Background: Multi-transfused thalassemia major (TM) patients frequently develop severe endocrine complications, mainly due to iron overload, anemia and chronic liver disease, which require prompt diagnosis, treatment and ... -
A smartphone-based consultation system for acute burns – methodological challenges related to follow-up of the system
(Taylor & Francis Open, 2017)Background: A smartphone-based consultation system for acute burns is currently being implemented in the Western Cape, South Africa. Even though studies indicate that similar systems for burns tend to support valid diagnosis ... -
Medical mobile technologies – what is needed for a sustainable and scalable implementation on a global scale?
(Taylor & Francis Open, 2017)Current advances within medical technology show great potential from a global health perspective. Inexpensive, effective solutions to common problems within diagnostics, medical procedures and access to medical information ... -
Image-based mHealth for remote diagnostic assistance a means to promote equity in quality care
(Taylor & Francis Open, 2017)No abstract -
Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations
(Taylor & Francis Open, 2017)Data from many high- and low- or middle-income countries have linked exposures during key developmental periods (in particular pregnancy and infancy) to later health and disease. Africa faces substantial challenges with ... -
The archaeology of teaching and the evolution of Homo docens
(University of Chicago Press, 2017-4)Teaching is present in all human societies, while within other species it is very limited. Something happened during the evolution of Homo sapiens that also made us Homo docens—the teaching animal. Based on discussions ... -
Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries
(eLife Sciences Publications, 2017)Lateralization is a fundamental principle of nervous system organization but its molecular determinants are mostly unknown. In humans, asymmetric gene expression in the fetal cortex has been suggested as the molecular basis ... -
How spatial scale shapes the generation and management of multiple ecosystem services
(Ecological Society of America, 2017)The spatial extent of ecological processes has consequences for the generation of ecosystem services related to them. However, management often fails to consider issues of scale when targeting ecological processes underpinning ... -
Evolution of computational models in BioModels Database and the Physiome Model Repository
(BioMed Central, 2018-04-12)ENGLISH SUMMARY : Background: A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and ... -
Tracking the cellulolytic activity of Clostridium thermocellum biofilms
(BioMed Central, 2013-11-29)Background Microbial cellulose conversion by Clostridium thermocellum 27405 occurs predominantly through the activity of substrate-adherent bacteria organized in thin, primarily single cell-layered biofilms. The importance ... -
Still Bay Point-production strategies at Hollow Rock Shelter and Umhlatuzana Rock Shelter and Knowledge-transfer systems in Southern Africa at about 80-70 thousand years ago
(Public Library of Science, 2016)It has been suggested that technological variations associated with Still Bay assemblages of southern Africa have not been addressed adequately. Here we present a study developed to explore regional and temporal variations ... -
Systems approach to the study of brain damage in the very preterm newborn
(Frontiers Media, 2016)Background: A systems approach to the study of brain damage in very preterm newborns has been lacking. Methods: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and ... -
TRAPLINE : a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation
(BioMed Central, 2016)Background: Technical advances in Next Generation Sequencing (NGS) provide a means to acquire deeper insights into cellular functions. The lack of standardized and automated methodologies poses a challenge for the analysis ... -
Death domain signaling by disulfide-linked dimers of the p75 neurotrophin receptor mediates neuronal death in the CNS
(Society for Neuroscience, 2016-05-18)The p75 neurotrophin receptor (p75NTR) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway. The oligomeric state and activation mechanism that enable p75NTR to mediate these ... -
COMODI : an ontology to characterise differences in versions of computational models in biology
(BioMed Central, 2016-07-11)Background: Open model repositories provide ready-to-reuse computational models of biological systems. Models within those repositories evolve over time, leading to different model versions. Taken together, the underlying ... -
Strategies for managing complex social-ecological systems in the face of uncertainty : examples from South Africa and beyond
(Resilience Alliance, 2015)Improving our ability to manage complex, rapidly changing social-ecological systems is one of the defining challenges of the 21st century. This is particularly crucial if large-scale poverty alleviation is to be secured ... -
On the physiology of jouissance : interpreting the mesolimbic dopaminergic reward functions from a psychoanalytic perspective
(Frontiers, 2013-11-06)Jouissance is a Lacanian concept, infamous for being impervious to understanding and which expresses the paradoxical satisfaction that a subject may derive from his symptom. On the basis of Freud’s “experience of satisfaction” ... -
After Fukushima : the precautionary principle revisited
(AOSIS Publishing, 2012-12-06)Etienne de Villiers, more than other theologians, elaborates on basic elements of a Christian ethics of responsibility. He distinguishes between retrospective and prospective responsibility. The prospective aspect attracted ... -
Anti-inflammatory effects of reactive oxygen species : a multi-valued logical model validated by formal concept analysis
(BioMed Central, 2014-09)Background: Recent findings suggest that in pancreatic acinar cells stimulated with bile acid, a pro-apoptotic effect of reactive oxygen species (ROS) dominates their effect on necrosis and spreading of inflammation. The ...
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