A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation.
Date
2008-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Stellenbosch : Stellenbosch University
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western
countries, extending from steatosis (FLD) to steatohepatitis (NASH). Differentiation between
NASH and nonprogressive NAFLD is difficult on clinical grounds therefore a need exists to
identify reliable biomarkers of disease progression.
The aims of the study were 1) to describe the disease profile of NAFLD/NASH in South African
patients of the Western Cape, 2) to investigate the metabolic derangements associated with this
condition, including insulin resistance, lipid abnormalities and liver fibrogenesis, and 3) to
assess the possible involvement of candidate genes in relation to the disease phenotype in the
patient cohort.
A total of 233 patients (73% female) were enrolled in this study, consisting of 69% Cape
Coloured, 25% Caucasian, 5% Black and 1% Asian individuals. All subjects were obese or
overweight based on the assessment of body mass index (BMI). Screening for NAFLD identified
182 patients (87%) with ultrasonographical evidence of fatty infiltration and/or hepatomegaly.
Liver biopsies were performed on patients with persistently abnormal liver functions and/or
hepatomegaly. NAFLD was confirmed histologically in 111 patients of whom 36% had NASH
and 17% advanced liver fibrosis. None of the Black patients had advanced fibrosis.
Description
Thesis (PhD (Medicine. Internal Medicine))--Stellenbosch University, 2008.
Keywords
Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Insulin resistance, Liver cirrhosis, Dissertations -- Internal medicine, Theses -- Internal medicine