A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation.

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dc.contributor.advisorKotze, Maritha J.en_ZA
dc.contributor.advisorVan Rensburg, C. J.en_ZA
dc.contributor.authorKruger, F. C.en_ZA
dc.contributor.otherStellenbosch University. Faculty of Health Sciences. Dept. of Medicine. Internal Medicine.
dc.date.accessioned2008-11-07T13:58:29Zen_ZA
dc.date.accessioned2010-06-01T08:21:05Z
dc.date.available2008-11-07T13:58:29Zen_ZA
dc.date.available2010-06-01T08:21:05Z
dc.date.issued2008-12en_ZA
dc.descriptionThesis (PhD (Medicine. Internal Medicine))--Stellenbosch University, 2008.en_ZA
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western countries, extending from steatosis (FLD) to steatohepatitis (NASH). Differentiation between NASH and nonprogressive NAFLD is difficult on clinical grounds therefore a need exists to identify reliable biomarkers of disease progression. The aims of the study were 1) to describe the disease profile of NAFLD/NASH in South African patients of the Western Cape, 2) to investigate the metabolic derangements associated with this condition, including insulin resistance, lipid abnormalities and liver fibrogenesis, and 3) to assess the possible involvement of candidate genes in relation to the disease phenotype in the patient cohort. A total of 233 patients (73% female) were enrolled in this study, consisting of 69% Cape Coloured, 25% Caucasian, 5% Black and 1% Asian individuals. All subjects were obese or overweight based on the assessment of body mass index (BMI). Screening for NAFLD identified 182 patients (87%) with ultrasonographical evidence of fatty infiltration and/or hepatomegaly. Liver biopsies were performed on patients with persistently abnormal liver functions and/or hepatomegaly. NAFLD was confirmed histologically in 111 patients of whom 36% had NASH and 17% advanced liver fibrosis. None of the Black patients had advanced fibrosis.en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/1415
dc.language.isoenen_ZA
dc.publisherStellenbosch : Stellenbosch University
dc.rights.holderStellenbosch University
dc.subjectNon-alcoholic fatty liver diseaseen_ZA
dc.subjectNon-alcoholic steatohepatitisen_ZA
dc.subjectInsulin resistanceen_ZA
dc.subjectLiver cirrhosisen_ZA
dc.subjectDissertations -- Internal medicine
dc.subjectTheses -- Internal medicine
dc.titleA study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation.en_ZA
dc.typeThesis
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Doctoral Degrees (General Internal Medicine)