The optimal dosage of ketanserin for patients with severe hypertension in pregnancy
Date
2002
Authors
Van Schie D.L.
De Jeu R.M.
Steyn D.Wilhelm
Odendaal H.J.
Van Geijn H.P.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: To establish the optimal dosage of ketanserin in the treatment of severe hypertension in pregnancy. Study design: A double blind prospective randomised controlled trail, comparing 10mg ketanserin given as intravenous boluses either every 10 or 20min, until the therapeutic goal of 90mmHg (diastolic blood pressure) was reached, to a maximum of eight boluses. Main outcome measures were treatment failures and caesarean sections for fetal distress. Results: There was no difference in reaching the therapeutic goal between patients receiving 10mg ketanserin either every 10 or 20min. Conclusion: Ketanserin appears to be an attractive medicine in the treatment of severe hypertension in pregnancy, but the optimal dosage could not be established. Copyright © 2002 Elsevier Science Ireland Ltd.
Description
Keywords
ketanserin, adult, article, blood pressure regulation, cesarean section, clinical article, clinical trial, controlled clinical trial, controlled study, diastolic blood pressure, double blind procedure, drug efficacy, female, fetus distress, human, male, maternal hypertension, maternal mortality, preeclampsia, priority journal, randomized controlled trial, Adult, Antihypertensive Agents, Cesarean Section, Double-Blind Method, Female, Humans, Hypertension, Ketanserin, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Cardiovascular, Prospective Studies
Citation
European Journal of Obstetrics Gynecology and Reproductive Biology
102
2
102
2