The optimal dosage of ketanserin for patients with severe hypertension in pregnancy

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dc.contributor.authorVan Schie D.L.
dc.contributor.authorDe Jeu R.M.
dc.contributor.authorSteyn D.Wilhelm
dc.contributor.authorOdendaal H.J.
dc.contributor.authorVan Geijn H.P.
dc.date.accessioned2011-05-15T16:16:21Z
dc.date.available2011-05-15T16:16:21Z
dc.date.issued2002
dc.description.abstractObjective: To establish the optimal dosage of ketanserin in the treatment of severe hypertension in pregnancy. Study design: A double blind prospective randomised controlled trail, comparing 10mg ketanserin given as intravenous boluses either every 10 or 20min, until the therapeutic goal of 90mmHg (diastolic blood pressure) was reached, to a maximum of eight boluses. Main outcome measures were treatment failures and caesarean sections for fetal distress. Results: There was no difference in reaching the therapeutic goal between patients receiving 10mg ketanserin either every 10 or 20min. Conclusion: Ketanserin appears to be an attractive medicine in the treatment of severe hypertension in pregnancy, but the optimal dosage could not be established. Copyright © 2002 Elsevier Science Ireland Ltd.
dc.description.versionArticle
dc.identifier.citationEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.identifier.citation102
dc.identifier.citation2
dc.identifier.issn03012115
dc.identifier.other10.1016/S0301-2115(01)00611-X
dc.identifier.urihttp://hdl.handle.net/10019.1/13744
dc.subjectketanserin
dc.subjectadult
dc.subjectarticle
dc.subjectblood pressure regulation
dc.subjectcesarean section
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdiastolic blood pressure
dc.subjectdouble blind procedure
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjectfetus distress
dc.subjecthuman
dc.subjectmale
dc.subjectmaternal hypertension
dc.subjectmaternal mortality
dc.subjectpreeclampsia
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectAdult
dc.subjectAntihypertensive Agents
dc.subjectCesarean Section
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectKetanserin
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectPregnancy Complications, Cardiovascular
dc.subjectProspective Studies
dc.titleThe optimal dosage of ketanserin for patients with severe hypertension in pregnancy
dc.typeArticle
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