Effect of chronic antidepressant treatment on noradrenergic modulation of [3H]dopamine release from rat nucleus accumbens and striatal slices
Date
1987
Authors
Russell V.A.
Nurse B.
Lamm M.C.L.
Taljaard J.J.F.
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Abstract
Unlike desipramine, a potent blocker of noradrenaline uptake, the antidepressant drugs, mianserin and citalopram did not, after chronic administration (28 days), attenuate the clonidine-induced inhibition of [3H]dopamine (DA) release from rat nucleus accumbens slices. Mianserin, like desipramine, failed to alter the isoproterenol-induced enhancement of [3H]DA release from rat nucleus accumbens and striatal slices. These findings suggest that antidepressant action does not necessarily involve desensitization of central α2- or β-adrenoceptors which influence neuronal transmission.
Description
Keywords
adrenergic receptor, antidepressant agent, citalopram, clonidine, desipramine, dopamine, dopamine h 3, isoprenaline, mianserin, phentolamine, radioisotope, unclassified drug, yohimbine, animal cell, brain slice, central nervous system, corpus striatum, dopamine release, drug interaction, drug receptor binding, nonhuman, nucleus accumbens, priority journal, rat, Adrenergic Fibers, Animal, Antidepressive Agents, Citalopram, Comparative Study, Corpus Striatum, Dopamine, Male, Mianserin, Norepinephrine, Nucleus Accumbens, Propylamines, Rats, Rats, Inbred Strains, Septal Nuclei, Support, Non-U.S. Gov't
Citation
Brain Research
410
1
410
1