Effect of chronic antidepressant treatment on noradrenergic modulation of [3H]dopamine release from rat nucleus accumbens and striatal slices

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dc.contributor.authorRussell V.A.
dc.contributor.authorNurse B.
dc.contributor.authorLamm M.C.L.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:15:45Z
dc.date.available2011-05-15T16:15:45Z
dc.date.issued1987
dc.description.abstractUnlike desipramine, a potent blocker of noradrenaline uptake, the antidepressant drugs, mianserin and citalopram did not, after chronic administration (28 days), attenuate the clonidine-induced inhibition of [3H]dopamine (DA) release from rat nucleus accumbens slices. Mianserin, like desipramine, failed to alter the isoproterenol-induced enhancement of [3H]DA release from rat nucleus accumbens and striatal slices. These findings suggest that antidepressant action does not necessarily involve desensitization of central α2- or β-adrenoceptors which influence neuronal transmission.
dc.description.versionArticle
dc.identifier.citationBrain Research
dc.identifier.citation410
dc.identifier.citation1
dc.identifier.issn00068993
dc.identifier.urihttp://hdl.handle.net/10019.1/13469
dc.subjectadrenergic receptor
dc.subjectantidepressant agent
dc.subjectcitalopram
dc.subjectclonidine
dc.subjectdesipramine
dc.subjectdopamine
dc.subjectdopamine h 3
dc.subjectisoprenaline
dc.subjectmianserin
dc.subjectphentolamine
dc.subjectradioisotope
dc.subjectunclassified drug
dc.subjectyohimbine
dc.subjectanimal cell
dc.subjectbrain slice
dc.subjectcentral nervous system
dc.subjectcorpus striatum
dc.subjectdopamine release
dc.subjectdrug interaction
dc.subjectdrug receptor binding
dc.subjectnonhuman
dc.subjectnucleus accumbens
dc.subjectpriority journal
dc.subjectrat
dc.subjectAdrenergic Fibers
dc.subjectAnimal
dc.subjectAntidepressive Agents
dc.subjectCitalopram
dc.subjectComparative Study
dc.subjectCorpus Striatum
dc.subjectDopamine
dc.subjectMale
dc.subjectMianserin
dc.subjectNorepinephrine
dc.subjectNucleus Accumbens
dc.subjectPropylamines
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSeptal Nuclei
dc.subjectSupport, Non-U.S. Gov't
dc.titleEffect of chronic antidepressant treatment on noradrenergic modulation of [3H]dopamine release from rat nucleus accumbens and striatal slices
dc.typeArticle
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