Evidence that the stimulatory effect of neurotensin on dopamine release in rat nucleus accumbens slices is independent of dopamine D2-receptor activation
Date
1990
Authors
Reyneke L.
Russel V.A.
Taljaard J.J.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Neurotensin (NT, 10-9 M and 10-7 M) increased the electrically stimulated release of [3H]dopamine (DA) in rat nucleus accumbens slices. This effect was not altered by activation of DA D2-receptors with high or low concentrations of quinpirole (10-6 M and 10-8 M) or blockade of DA D2-receptors with near maximal concentrations of sulpiride (10-6 M and 10-5 M). The sulpiride-mediated increase in [3H]DA release and the release induced by NT were additive. These results suggest that NT functions independently of DA D2-receptor activation to modulate DA release in the nucleus accumbens. NT did not modulate the simultaneous release of [14C]acetylcholine.
Description
Keywords
neurotensin, quinpirole, sulpiride, acetylcholine release, animal tissue, article, brain slice, controlled study, dopamine release, male, nonhuman, nucleus accumbens, priority journal, rat, Acetylcholine, Animal, Dopamine, Dopamine Agents, Electric Stimulation, Ergolines, In Vitro, Kinetics, Male, Neurotensin, Nucleus Accumbens, Quinpirole, Rats, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Dopamine D2, Sulpiride, Support, Non-U.S. Gov't
Citation
Brain Research
534
1-2
534
1-2