Evidence that the stimulatory effect of neurotensin on dopamine release in rat nucleus accumbens slices is independent of dopamine D2-receptor activation

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dc.contributor.authorReyneke L.
dc.contributor.authorRussel V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:15:44Z
dc.date.available2011-05-15T16:15:44Z
dc.date.issued1990
dc.description.abstractNeurotensin (NT, 10-9 M and 10-7 M) increased the electrically stimulated release of [3H]dopamine (DA) in rat nucleus accumbens slices. This effect was not altered by activation of DA D2-receptors with high or low concentrations of quinpirole (10-6 M and 10-8 M) or blockade of DA D2-receptors with near maximal concentrations of sulpiride (10-6 M and 10-5 M). The sulpiride-mediated increase in [3H]DA release and the release induced by NT were additive. These results suggest that NT functions independently of DA D2-receptor activation to modulate DA release in the nucleus accumbens. NT did not modulate the simultaneous release of [14C]acetylcholine.
dc.description.versionArticle
dc.identifier.citationBrain Research
dc.identifier.citation534
dc.identifier.citation1-2
dc.identifier.issn00068993
dc.identifier.other10.1016/0006-8993(90)90128-X
dc.identifier.urihttp://hdl.handle.net/10019.1/13465
dc.subjectneurotensin
dc.subjectquinpirole
dc.subjectsulpiride
dc.subjectacetylcholine release
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbrain slice
dc.subjectcontrolled study
dc.subjectdopamine release
dc.subjectmale
dc.subjectnonhuman
dc.subjectnucleus accumbens
dc.subjectpriority journal
dc.subjectrat
dc.subjectAcetylcholine
dc.subjectAnimal
dc.subjectDopamine
dc.subjectDopamine Agents
dc.subjectElectric Stimulation
dc.subjectErgolines
dc.subjectIn Vitro
dc.subjectKinetics
dc.subjectMale
dc.subjectNeurotensin
dc.subjectNucleus Accumbens
dc.subjectQuinpirole
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Dopamine
dc.subjectReceptors, Dopamine D2
dc.subjectSulpiride
dc.subjectSupport, Non-U.S. Gov't
dc.titleEvidence that the stimulatory effect of neurotensin on dopamine release in rat nucleus accumbens slices is independent of dopamine D2-receptor activation
dc.typeArticle
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