Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample

Van Rensburg E.J. ; Engelbrecht S. ; Van Heerden W.F.P. ; Raubennheimer E.J. ; Schoub B.D. (1996)


Background. The incidence of oral squamous cell carcinoma (OSCC) is on the increase in developing countries. Materials and Methods. Formalin fixed paraffin embedded blocks of OSCCs from a Black South African population sample of peri-urban and rural origin were selected as follows: Group 1-57 OSCCs with a mean age of 59 years; Group 2 - 43 OSCCs all cases younger than 40 years; Group 3 - 46 OSCCs with blocks containing only tumour tissue without any normal epithelium and Group 4, a control group of 38 non-neoplastic epithelial lesions. Type specific primers were used in a standard PCR to amplify a segment of the E6 region of HPV 6, 11, 16 and 18. Results. HPV 11 and 16 DNA were found in one sample each from groups 1 and 2 respectively. Conclusion. HPV is not an etiologic factor in the development of OSCC in the population studied.

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