• Elucidation of a human urine metabolite as a seryl-leucine glycopeptide and as a biomarker of effective anti-tuberculosis therapy 

  Fitzgerald, Bryna L.; Islam, M. Nurul; Graham, Barbara; Mahapatra, Sebabrata; Webb, Kristofor; Boom, W. Henry; Malherbe, Stephanus T.; Joloba, Moses L.; Johnson, John L.; Winter, Jill; Walzl, Gerhard; Belisle, John T. (American Chemical Society, 2018-12-26)

  ENGLISH ABSTRACT: The evaluation of new tuberculosis (TB) therapies is limited by the paucity of biomarkers to monitor treatment response. Previous work detected an uncharacterized urine metabolite with a molecular mass ...
• Prevalence of substance use amongst people living with human immunodeficiency virus who attend primary healthcare services in Mthatha, South Africa 

  Kaswa, Ramprakash; De Villiers, Marietjie (AOSISPublisher's version, 2020)

  Background: About 13.3% of the South African population use some kind of substance during their lifetime. The incidence of substance use disorders is twice the global average. The use of various substances amongst people ...
• Sustainable workforce : South African Audiologists and Speech Therapists 

  Pillay, Mershen; Tiwari, Ritika; Kathard, Harsha; Chikte, Usuf (World Health Organization, 2020-07-01)

  Background: Audiologists and Speech Therapists play a vital role in addressing sustainable development goals by supporting people who are marginalised due to communication challenges. The global burden of disease and ...
• A case report of an aorto-pulmonary-venacaval fistula after penetrating cardiac injury 

  Koen, Johannes Gerhardus; Wagenaar, Riegardt; Janson, Jacques T. (Oxford University Press, 2020-12-15)

  Background: Penetrating cardiac injury (PCI) is an accepted burden in high violent crime areas. Traumatic intracardiac fistulae are however not that commonly detected on initial presentation, with most of these injuries ...
• Adolescent mothers’ lived experiences whilst providing continuous kangaroo mother care : a qualitative study 

  Robertson, Anneline E.; Crowley, Talitha (AOSIS, 2020)

  Background: Kangaroo mother care (KMC) is the practice of skin-to-skin contact between an infant and parent and has been found to improve the growth and decrease the morbidity and mortality of low-birth-weight and premature ...
• A situational mapping overview of training programmes for community-based rehabilitation workers in Southern Africa : strategies for strengthening accessible rural rehabilitation practice 

  Ned, Lieketseng; Tiwari, Ritika; Hess-April, Lucia; Lorenzo, Theresa; Chikte, U. M. E. (Frontiers Media, 2020)

  In 2018, the United Nations global report showed that people with disabilities, who make up 15% of the worlds' population, have poorer health and rehabilitation access (SDG 3). Without improving the needed person-centered ...
• Factors associated with antiretroviral treatment failure among people living with HIV on antiretroviral therapy in resource-poor settings : a systematic review and meta analysis 

  Lailulo, Yishak; Kitenge, Marcel; Jaffer, Shahista; Aluko, Omololu; Nyasulu, Peter S. (BMC (part of Springer Nature), 2020)

  Background: Despite the increase in the number of people accessing antiretroviral therapy (ART), there is limited data regarding treatment failure and its related factors among HIV-positive individuals enrolled in HIV care ...
• Hyperplastic polyp or sessile serrated lesion? the contribution of serial sections to reclassification 

  Jaravaza, Diana R.; Rigby, Jonathan M. (BMC (part of Springer Nature), 2020)

  Background: The histological discrimination of hyperplastic polyps from sessile serrated lesions can be difficult. Sessile serrated lesions and hyperplastic polyps are types of serrated polyps which confer different ...
• Motor skill intervention for pre-school children : a scoping review 

  Van der Walt, Janke; Plastow, Nicola A.; Unger, Marianne (AOSIS, 2020)

  Background: There is a high prevalence of motor skill difficulties amongst pre-school children living in low socio-economic areas. Motor skill impairment can affect these children’s school readiness and academic progress, ...
• Mapping oral cancer research in South Africa 

  Botha, Paul J.; Schoonees, Anel; Pontes, Carla C. (South African Dental Association, 2018)

  The aim of the present study was to review the scope of oral squamous cell carcinoma (OSCC) research in South Africa, including its epidemiology, diagnosis, associated risk factors and management. All publications relating ...
• Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice 

  Dludla, P. V.; Gabuza, K. B.; Muller, C. J. F.; Joubert, E.; Louw, J.; Johnson, R. (Institute of Physiology, The Czech Academy of Sciences, 2018-07-25)

  ENGLISH ABSTRACT: Metformin is the first line therapy of type 2 diabetics, but continued reduction of their life expectancy warrants further investigation into alternative treatment strategies. This study reports on the ...
• Antioxidant activities of Basella alba aqueous leave extract in blood, pancreas, and gonadal tissues of diabetic male Wistar rats 

  Arokoyo, Dennis Seyi; Oyeyipo, Ibukun Peter; Du Plessis, Stefan Simon; Aboua, Yapo Guillaume (Wolters Kluwer, 2018)

  Background: Oxidative stress is frequently identified as a key element in the pathophysiology of many complications of diabetes mellitus, including reproductive complications. The antioxidant potential of medicinal ...
• Genetic association of lipids and lipid drug targets with abdominal aortic aneurysm : a meta-analysis 

  Harrison, Seamus C.; Holmes, Michael V.; Burgess, Stephen; Asselbergs, Folkert W.; Jones, Gregory T.; Baas, Annette F.; Van 't Hof, F. N.; De Bakker, Paul I. W.; Blankensteijn, Jan D.; Powell, Janet T.; Saratzis, Athanasios; De Borst, Gert J.; Swerdlow, Daniel I.; Van der Graaf, Yolanda; Van Rij, Andre M.; Carey, David J.; Elmore, James R.; Tromp, Gerard; Kuivaniemi, Helena; Sayers, Robert D.; Samani, Nilesh J.; Bown, Matthew J.; Humphries, Steve E. (American Medical Association, 2018)

  Importance Risk factors for abdominal aortic aneurysm (AAA) are largely unknown, which has hampered the development of nonsurgical treatments to alter the natural history of disease. Objective To investigate the ...
• Clinical Ethics Committees in Africa : lost in the shadow of RECs/IRBs? 

  Moodley, Keymanthri; Kabanda, Siti Mukaumbya; Soldaat, Leza; Kleinsmidt, Anita; Obasa, Adetayo Emmanuel; Kling, Sharon (BioMed Central, 2020)

  Background: Clinical Ethics Committees (CECs) are well established at healthcare institutions in resource-rich countries. However, there is limited information on established CECs in resource poor countries, especially ...
• Exploring the factors that affect new graduates’ transition from students to health professionals : a systematic integrative review protocol 

  Opoku, Eric Nkansah; Van Niekerk, Lana; Jacobs-Nzuzi Khuabi, Lee-Ann (BMJ Publishing Group, 2020-05-15)

  Introduction: To become a competent health professional, the nature of new graduates’ transition plays a fundamental role. The systematic integrative review will aim to identify the existing literature pertaining to the ...
• Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa 

  Du Preez, K.; Du Plessis, L.; O’Connell, N.; Hesseling, A. C. (International Union Against Tuberculosis and Lung Disease, 2018)

  SETTING: The Khayelitsha subdistrict has the highest burden of reported tuberculosis (TB) cases in Cape Town, Western Cape Province, South Africa. OBJECTIVES: To characterise the TB burden, spectrum and treatment outcomes ...
• Effect of female sex work-targeted community-based interventions along the HIV treatment cascade in sub-Saharan Africa : a systematic review protocol 

  Atuhaire, Lydia; Adetokunboh, Olatunji; Shumba, Constance; Nyasulu, Peter S. (BMJ Publishing Group, 2020)

  Introduction: Female sex workers (FSWs) are a known high-risk group that are at increased risk of HIV transmission due to exposure to multiple sexual partners and inability to negotiate safe sex attributed to challenging ...
• The impact of COVID-19 on routine patient care from a laboratory perspective 

  Kruger, E. C.; Banderker, R.; Erasmus, R. T.; Zemlin, A. E. (Health & Medical Publishing Group, 2020-11-05)

  Background. Globally, few studies have examined the effect of the COVID-19 pandemic on routine patient care and follow-up. Objectives. To evaluate the effect of the COVID-19 response on biochemical test requests received ...
• Opportunities for mobile app–based adherence support for children with tuberculosis in South Africa 

  Morse, Rachel M.; Myburgh, Hanlie; Reubi, David; Archey, Ava E.; Busakwe, Leletu; Garcia-Prats, Anthony J.; Hesseling, Anneke C.; Jacobs, Stephanie; Mbaba, Sharon; Meyerson, Kyla; Seddon, James A.; Van Der Zalm, Marieke M.; Wademan, Dillon T.; Hoddinott, Graeme (JMIR Publications, 2020)

  ENGLISH ABSTRACT: Tuberculosis is the number one infectious cause of death globally. Young children, generally those younger than 5 years, are at the highest risk of progressing from tuberculosis infection to tuberculosis ...
• Closing the reporting gap for childhood tuberculosis in South Africa : improving hospital referrals and linkages 

  Du Preez, K.; Schaaf, H. S.; Dunbar, R.; Swartz, A.; Naidoo, P.; Hesseling, A. C. (IUATLD -- International Union Against Tuberculosis and Lung Disease, 2020-03-21)

  Setting: A referral hospital in Cape Town, Western Cape Province, Republic of South Africa. Objective: To measure the impact of a hospital-based referral service (intervention) to reduce initial loss to follow-up among ...

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