• 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion 

  Leisching, G.; Ali, A.; Cole, V.; Baker, B. (Elsevier, 2019-12)

  Host cytoplasmic surveillance pathways are known to elicit type I interferon (IFN) responses which are crucial to antimicrobial defense mechanisms. Oligoadenylate synthetase-like (OASL) protein has been extensively ...
• Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients 

  Lubbers, Rosalie; Sutherland, Jayne S.; Goletti, Delia; De Paus, Roelof A.; Dijkstra, Douwe J.; Van Moorsel, Coline H. M.; Veltkamp, Marcel; Vestjens, Stefan M. T.; Bos, Willem J. W.; Petrone, Linda; Malherbe, Stephanus T.; Walzl, Gerhard; Gelderman, Kyra A.; Groeneveld, Geert H.; Geluk, Annemieke; Ottenhoff, Tom H. M.; Joosten, Simone A.; Trouw, Leendert A. (Elsevier, 2020-03-13)

  Background To facilitate better discrimination between patients with active tuberculosis (TB) and latent TB infection (LTBI), whole blood transcriptomic studies have been performed to identify novel candidate host biomarkers. ...
• An analysis of biopsies for suspected skin cancer at a tertiary care dermatology clinic in the Western Cape province of South Africa 

  De Wet, Johann; Steyn, Minette; Jordaan, Henry F.; Smith, Rhodine; Claasens, Saskya; Visser, Willem I. (Hindawi, 2020)

  Background. Skin cancer is a growing health concern worldwide. It is the most common malignancy in South Africa and places a large burden on the public healthcare sector. There is a paucity of published scientific data on ...
• Peripheral blood lymphocyte proviral DNA predicts neurocognitive impairment in clade C HIV 

  Ruhanya, Vurayai; Jacobs, Graeme Brendon; Nyandoro, George; Paul, Robert H.; Joska, John A.; Seedat, Soraya; Glashoff, Richard Helmuth; Engelbrecht, Susan (Springer, 2020-07)

  It is not known if proviral DNA in the periphery corresponds to cognitive status in clade C as it does in clade B and recombinant forms. A cross-sectional study was conducted on participants investigated for HIV-associated ...
• Nonunion – consensus from the 4th annual meeting of the Danish Orthopaedic Trauma Society 

  Schmal, Hagen; Brix, Michael; Bue, Mats; Ekman, Anna; Ferreira, Nando; Gottlieb, Hans; Kold, Soren; Taylor, Andrew; Tengberg, Peter Toft; Ban, Ilija; Danish Orthopaedic Trauma Society (Bioscientifica, 2020-01)

  Nonunions are a relevant economic burden affecting about 1.9% of all fractures. Rather than specifying a certain time frame, a nonunion is better defined as a fracture that will not heal without further intervention. Successful ...
• Automated radiation treatment planning for cervical cancer 

  Rhee, Dong Joo; Jhingran, Anuja; Kisling, Kelly; Cardenas, Carlos; Simonds, Hannah; Court, Laurence (Elsevier, 2020-10)

  The radiation treatment-planning process includes contouring, planning, and reviewing the final plan, and each component requires substantial time and effort from multiple experts. Automation of treatment planning can save ...
• Alternative mechanisms for delivery of medication in South Africa : a scoping review 

  Mash, Robert; Christian, Carmen; Chigwanda, Ruvimbo V. (AOSIS, 2021-08)

  Background: The number of people in South Africa with chronic conditions is a challenge to the health system. In response to the coronavirus infection, health services in Cape Town introduced home delivery of medication ...
• Academy calls on South Africans to vaccinate 

  Mash, Bob (AOSIS, 2021-10)

  Coronavirus disease 2019 (COVID-19) vaccine hesitancy in South Africa has been fuelled by conspiracy theories and misinformation. Unfortunately, some of this misinformation has come from health professionals, the most ...
• A case series of post-partum haemorrhage managed using Ellavi uterine balloon tamponade in a rural regional hospital 

  Theron, Gerhard B.; Mpumlwana, Vulikaya (AOSIS, 2021-05)

  Uterine balloon tamponade (UBT) should be attempted once emergency measures have been applied and medical treatment for post-partum haemorrhage (PPH) resulting from an atonic uterus has failed. Sinapi Biomedical (Pty) Ltd ...
• Mood responses to COVID-19 : implications for family practice in South Africa 

  Van Wijk, Charles; Majola, Pinky Z. (AOSIS, 2021-07)

  The effect of coronavirus disease 2019 (COVID-19) on the mood responses of individuals is an important indicator of how society is coping with the pandemic. Characterising mood responses in a South African sample could ...
• Digit ratio as an endophenotype in a schizophrenia population 

  Nieuwoudt, Wilhelm D. B.; Smit, Inge M.; Niehaus, Dana; Koen, Liezl; Jordaan, Esme (AOSIS, 2021-03)

  Background: Schizophrenia is a debilitating mental health condition affecting the lives of many South Africans. The origins of the heterogeneity in the presentation of the illness remain uncertain. Aim: This cross-sectional ...
• Becoming a Xhosa traditional healer : the calling, illness, conflict and belonging 

  Van der Watt, Alberta S. J.; Biederman, Sarah V.; Abdulmalik, Jibril O.; Mbanga, Irene; Das-Brailsford, Pricilla; Seedat, Soraya, 1966- (AOSIS, 2021-03)

  Background: Traditional healers (THs) are an important part of the healthcare system in sub-Saharan Africa. Understanding their training, experiences of becoming healers and their perceived roles in society is critical. Aim: ...
• Associations of premorbid adjustment with type and timing of childhood trauma in first-episode schizophrenia spectrum disorders 

  Smit, Anna M.; Kilian, Sanja; Emsley, Robin A.; Luckhoff, Hilmar K.; Swartz, Leslie; Seedat, Soraya; Asmal, Laila (AOSIS, 2021-06)

  Background: Childhood trauma may contribute to poorer premorbid social and academic adjustment which may be a risk factor for schizophrenia. Aim: We explored the relationship between premorbid adjustment and childhood ...
• Support nurses and midwives to strengthen healthcare systems 

  Fields, Bronwyn; Sibanda, Bongi; Couper, Ian (James Cook University, 2020-06-13)

  Nurses and midwives make up more than half of the global health workforce1. WHO has designated 2020 as the Year of the Nurse and Midwife2 to recognize their contribution, and to highlight the challenges they face in meeting ...
• Sex as a spectrum : inclusive anatomical education and the translation thereof into clinical practice 

  Lochner, Ruan Dawid. (2022-11)

  ENGLISH ABSTRACT: Introduction: Transgender and non-binary individuals repeatedly experience erasure of their identity in healthcare, ultimately leading to avoidance of healthcare environments, and unsupervised, self ...
• CRISPR interference screening model organisms for TB drugs development. 

  Masikantsi, Nenekazi (Stellenbosch : Stellenbosch University, 2022-11)

  ENGLISH ABSTRACT: Tuberculosis remains a global health burden despite the impetus in drug development mainly due to increasing Mycobacterium tuberculosis (M. tb) resistance against the available treatment regimens. ...
• Overexpression of mmpS5/mmpL5 in Mycobacterium tuberculosis reduces susceptibility to anti-tuberculosis drugs 

  Scott, Leere Ann (Stellenbosch : Stellenbosch University, 2022-12)

  ENGLISH ABSTRACT: Background: Bedaquiline (BDQ) is the first anti-tuberculosis (anti-TB) drug in recent years with a novel mode of action recommended for the treatment of multi-drug resistant-TB. Rv0678 is the most ...
• The role of the intestinal immune system in the development and treatment of type 2 diabetes 

  Parker, Kauthar (Stellenbosch : Stellenbosch University, 2022-11)

  ENGLISH ABSTRACT: Background: Type 2 diabetes (T2D) is largely correlated with obesity. Low-grade systemic inflammation and altered immune homeostasis in the gut are implicated in the pathogenesis of T2D. The intestinal ...
• The prevalence of burnout in nurses working in private healthcare facilities in Mbombela/Nelspruit during the COVID-19 pandemic 

  Lourens, Dirk Cornelus (Stellenbosch : Stellenbosch University, 2022-12)

  ENGLISH SUMMARY: Aims: To determine the prevalence of burnout in nurses working in the private healthcare facilities in Mbombela/Nelspruit during the COVID-19 pandemic. Background: The nursing profession has long been ...
• The vascular and endothelial effects of HIV, antiretroviral therapy and rooibos - functional effects and mechanism 

  Molopi, Dintle (Stellenbosch : Stellenbosch University, 2022-12)

  ENGLISH ABSTRACT: Individuals infected with human immunodeficiency virus-1 (HIV-1) are living longer but are at increased risk of cardiovascular disease (CVD). Antiretroviral therapy (ART) has been implicated in the ...

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