Faculty of Medicine and Health Sciences
The vision of the Faculty of Medicine and Health Sciences is to be a dynamic, people-centred and inclusive environment, internationally recognised for its excellence in research, education and clinical training in medicine and health sciences, and for the contribution it makes to improving health and health care in South Africa, the African continent and beyond.
This faculty was known as the Faculty of Health Sciences until 30 April 2012.
Sub-communities within this community
Recent Submissions
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Exploring service providers’ perspectives on the prevention and management of fetal alcohol spectrum disorders in South Africa : a qualitative study
(BMC (part of Springer Nature), 2018-11-06)Background: Fetal alcohol spectrum disorder (FASD) is among the leading causes of developmental and intellectual disabilities in individuals. Although efforts are being made toward the prevention and management of FASD ...
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Host-seeking efficiency can explain population dynamics of the tsetse fly Glossina morsitans morsitans in response to host density decline
(Public Library of Science, 2017)Females of all blood-feeding arthropod vectors must find and feed on a host in order to produce offspring. For tsetse—vectors of the trypanosomes that cause human and animal African trypanosomiasis—the problem is more ...
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A dynamic model for estimating adult female mortality from ovarian dissection data for the tsetse fly Glossina pallidipes Austen sampled in Zimbabwe
(Public Library of Science, 2017)Human and animal trypanosomiasis, spread by tsetse flies (Glossina spp), is a major public health concern in much of sub-Saharan Africa. The basic reproduction number of vector-borne diseases, such as trypanosomiasis, is ...
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Simple ideas that work : Celebrating development in persons with profound intellectual and multiple disabilities
(2018-06-05)The purpose of this article is to share some lessons learnt by an interdisciplinary therapy team working with persons with profound intellectual and multiple disabilities (PIMD), implemented in diverse, low-income contexts ...
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Exploring the potential of using cattle for malaria vector surveillance and control : a pilot study in western Kenya
(Biomed Central, 2017)Background: Malaria vector mosquitoes with exophilic and zoophilic tendencies, or with a high acceptance of alternative blood meal sources when preferred human blood-hosts are unavailable, may help maintain low but constant ...
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Once-monthly paliperidone palmitate in early stage schizophrenia – a retrospective, non-interventional 1-year study of patients with newly diagnosed schizophrenia
(Dove Medical Press, 2017)Background: Long-acting antipsychotic therapy may be best suited for patients in the early stage of schizophrenia, when the most can be done before disease progression associated with poor adherence occurs. We explored the ...
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EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy
(Elsevier, 2017-09)ENGLISH ABSTRACT: the presurgical evaluation of epilepsy as a reflection of the irritative zone. ESI of ictal scalp EEG to localize the seizure onset zone (SOZ) remains challenging. We investigated the value of an approach ...
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Excoriation (skin-picking) disorder : a systematic review of treatment options
(Dove Medical Press, 2017)Although pathological skin-picking has been documented in the medical literature since the 19th century, it has only recently been included as a distinct entity in psychiatric classification systems. In the Diagnostic and ...
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HIV as a cause of immune activation and immunosenescence
(Hindawi Publishing Corporation, 2017)Systemic immune activation has emerged as an essential component of the immunopathogenesis of HIV. It not only leads to faster disease progression, but also to accelerated decline of overall immune competence. HIV-associated ...
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Cross-cultural adaptation, content validation, and reliability of the Nigerian Composite Lifestyle CVD Risk Factors Questionnaire for adolescents among Yoruba rural adolescents in Nigeria
(Medical Association of Malawi, 2017)Background: Assessment of lifestyle risk factors must be culturally and contextually relevant and available in local languages. This paper reports on a study which aimed to cross-culturally adapt a composite lifestyle ...
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Progress and prospects for the control of HIV and tuberculosis in South Africa : a dynamical modelling study
(Elsevier, 2017)Background: In September, 2016, South Africa adopted a policy of providing antiretroviral treatment to everyone infected with HIV irrespective of their CD4 cell count. Studies of universal treatment and expanded prevention ...
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Genetic resistance to mycobacterium tuberculosis infection and disease
(Frontiers Media, 2017)Natural history studies of tuberculosis (TB) have revealed a spectrum of clinical outcomes after exposure to Mycobacterium tuberculosis, the cause of TB. Not all individuals exposed to the bacterium will become diseased ...
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Where do HIV-infected adolescents go after transfer? – Tracking transition/transfer of HIV-infected adolescents using linkage of cohort data to a health information system platform
(Wiley Open Access, 2017)Introduction: To evaluate long-term outcomes in HIV-infected adolescents, it is important to identify ways of tracking outcomes after transfer to a different health facility. The Department of Health (DoH) in the Western ...
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Twelve-year mortality in adults initiating antiretroviral therapy in South Africa
(Wiley Open Access, 2018)Introduction: South Africa has the largest number of individuals living with HIV and the largest antiretroviral therapy (ART) programme worldwide. In September 2016, ART eligibility was extended to all 7.1 million ...
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HIV viral load as an independent risk factor for tuberculosis in South Africa : collaborative analysis of cohort studies
(Wiley Open Access, 2017)Introduction: Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV replication as a risk ...
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Cross‐cultural assessment of HIV‐associated cognitive impairment using the Kaufman assessment battery for children : a systematic review
(Wiley Open Access, 2017)Introduction: Despite improved efficacy of, and access to, combination antiretroviral therapy (cART), HIV‐associated cognitive impairments remain prevalent in both children and adults. Neuropsychological tests that detect ...
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Barriers to HIV remission research in low- and middle-income countries
(Wiley Open Access, 2017)Introduction: HIV eradication and remission research has largely taken place in high-income countries. In low- and middleincome countries (LMIC), there may be factors that have a substantial impact on the size of the ...
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Access to assistive technology in two Southern African countries
(BMC (part of Springer Nature), 2018-10-19)Background: Millions of people in Southern Africa are deprived of basic human rights such as the right to education and work because of the large and growing unmet demand for assistive technologies (AT). Evidence is needed ...
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No evidence of HIV replication in children on antiretroviral therapy
(American Society for Clinical Investigation, 2017-04)ENGLISH ABSTRACT: It remains controversial whether current antiretroviral therapy (ART) fully suppresses the cycles of HIV replication and viral evolution in vivo. If replication persists in sanctuary sites such as the ...
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Advancing global health through cardiovascular research, mentorship, and capacity building : in memoriam, professor Bongani Mayosi (1967–2018)
(BMC (part of Springer Nature), 2018-10-03)ENGLISH ABSTRACT: No abstract available
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Feasibility, acceptability and potential sustainability of a ‘diagonal’ approach to health services for female sex workers in Mozambique
(BMC (part of Springer Nature), 2018-10-03)Background: Female sex workers (FSWs) in many settings have restricted access to sexual and reproductive health (SRH) services. We therefore conducted an implementation study to test a ‘diagonal’ intervention which ...
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A cross sectional survey to evaluate knowledge, attitudes and practices regarding seasonal influenza and influenza vaccination among diabetics in Pretoria, South Africa
(Elsevier, 2017-11-07)Background: In South Africa, influenza vaccination is recommended to all diabetics. However, vaccinationcoverage among diabetics remains low. Therefore, this study aimed to explore the knowledge, attitudes,and practices ...
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Anti-Group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection
(Elsevier, 2015-01-29)Background: HIV-exposed uninfected infants have increased infection risk and mortality compared to HIV-unexposed infants. HIV-exposed infants may be at increased risk of invasive GBS disease due to reduced maternal antibody ...
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Building capacity in primary care rehabilitation clinical practice guidelines : a South African initiative
(BioMed Central, 2018-09-29)Background: The large number of South Africans with disability who cannot access good quality rehabilitation presents a public health and human rights challenge. A cost-effective, efficient approach is required to address ...
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Impact of alcohol consumption on tuberculosis treatment outcomes : a prospective longitudinal cohort study protocol
(BioMed Central, 2018-09-29)Background: An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not ...
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Submaximal markers of fatigue and overreaching; implications for monitoring athletes
(Georg Thieme Verlag, 2017-07-13)ENGLISH ABSTRACT: The regular monitoring of athletes is important to fine-tune training and detect early symptoms of overreaching. Therefore the aim of this study was to determine if a noninvasive submaximal running test ...
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Habitual minimalist shod running biomechanics and the acute response to running barefoot
(Georg Thieme Verlag, 2017)ENGLISH ABSTRACT: The aim of the study was to determine whether habitual minimalist shoe runners present with purported favorable running biomechanithat reduce running injury risk such as initial loading rate. Eighteen ...
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The 17th International Congress on Infectious Diseases workshop on developing infection prevention and control resources for low - and middle-income countries
(Published by Elsevier on behalf of International Society for Infectious Diseases, 2017)Hospital-acquired infections (HAIs) are a major concern to healthcare systems around the world. They are associated with significant morbidity and mortality, in addition to increased hospitalization costs. Recent outbreaks, ...
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A retrospective audit of mitral valve repair surgery at Tygerberg Hospital
(South African Heart Association, 2018)Background: Mitral valve repair is well established as the preferred treatment modality for the majority of patients with degenerative mitral valve disease requiring intervention. Valve repair offers a distinct event-free ...
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Susceptibility to tuberculosis is associated with PI3K-dependent increased mobilization of neutrophils
(Frontiers Media, 2018)Neutrophilia is a condition commonly observed in patients with late-stage tuberculosis, but evidence suggests that increased neutrophil influx begins early after infection in susceptible hosts and functions to promote a ...
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