External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents
Date
2011
Authors
Vardas E.
Giuliano A.R.
Goldstone S.
Palefsky J.M.
Moreira Jr. E.D.
Penny M.E.
Aranda C.
Jessen H.
Moi H.
Ferris D.G.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background. We examined the baseline prevalence of penile, scrotal, and perineal/perianal human papillomavirus (HPV) in heterosexual men (HM). We also evaluated baseline characteristics of HM to assess factors associated with prevalent HPV detection. Methods. We tested serum samples from 3463 HM aged 16-24 years with 1-5 lifetime female sexual partners for antibodies to HPV 6, 11, 16, and 18. We collected baseline swab specimens for the detection of DNA of HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59 from 3 areas: penile, scrotal, and perineal/perianal. Risk factors for prevalent HPV DNA detection were evaluated. Results. The prevalence of any tested HPV type was 18.7% at the penis, 13.1% at the scrotum, 7.9% at the perineal/perianal region, and 21.0% at any site. Having >3 lifetime female sexual partners had the greatest impact on HPV prevalence: odds ratio (OR) 3.2 (95% confidence interval (CI) 2.1-4.9) for HPV 6, 11, 16, and 18; and OR 4.5 (95% CI 3.3-6.1) for all HPV types tested. HPV DNA detection was highest in Africa. Neither condom usage nor circumcision was associated with HPV DNA prevalence. Conclusion. Genital-HPV DNA detection is common in young, sexually active HM. We found HPV to be most prevalent in African men and least prevalent in men from the Asia-Pacific region. Increased numbers of sexual partners was an important risk factor for HPV DNA prevalence. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Description
Keywords
virus antibody, virus DNA, Wart virus vaccine, adolescent, adult, Africa, anus, article, circumcision, condom, condyloma acuminatum, controlled study, disease association, heterosexual male, human, Human papillomavirus type 11, Human papillomavirus type 16, Human papillomavirus type 18, Human papillomavirus type 31, Human papillomavirus type 33, Human papillomavirus type 35, Human papillomavirus type 39, Human papillomavirus type 45, Human papillomavirus type 51, Human papillomavirus type 52, Human papillomavirus type 56, Human papillomavirus type 58, Human papillomavirus type 59, Human papillomavirus type 6, infection risk, major clinical study, male, penis, perineum, prevalence, priority journal, scrotum, sexuality, virus detection, Wart virus, Adolescent, Adult, Anal Canal, Antibodies, Viral, DNA, Viral, Genital Diseases, Male, Heterosexuality, Humans, Male, Papillomaviridae, Papillomavirus Infections, Penis, Perineum, Prevalence, Risk Factors, Scrotum, Young Adult
Citation
Journal of Infectious Diseases
203
1
203
1