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External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents

dc.contributor.authorVardas E.
dc.contributor.authorGiuliano A.R.
dc.contributor.authorGoldstone S.
dc.contributor.authorPalefsky J.M.
dc.contributor.authorMoreira Jr. E.D.
dc.contributor.authorPenny M.E.
dc.contributor.authorAranda C.
dc.contributor.authorJessen H.
dc.contributor.authorMoi H.
dc.contributor.authorFerris D.G.
dc.contributor.authorLiaw K.-L.
dc.contributor.authorMarshall J.B.
dc.contributor.authorVuocolo S.
dc.contributor.authorBarr E.
dc.contributor.authorHaupt R.M.
dc.contributor.authorGarner E.I.O.
dc.contributor.authorGuris D.
dc.date.accessioned2011-05-15T16:03:32Z
dc.date.available2011-05-15T16:03:32Z
dc.date.issued2011
dc.identifier.citationJournal of Infectious Diseases
dc.identifier.citation203
dc.identifier.citation1
dc.identifier.issn221899
dc.identifier.other10.1093/infdis/jiq015
dc.identifier.urihttp://hdl.handle.net/10019.1/12666
dc.description.abstractBackground. We examined the baseline prevalence of penile, scrotal, and perineal/perianal human papillomavirus (HPV) in heterosexual men (HM). We also evaluated baseline characteristics of HM to assess factors associated with prevalent HPV detection. Methods. We tested serum samples from 3463 HM aged 16-24 years with 1-5 lifetime female sexual partners for antibodies to HPV 6, 11, 16, and 18. We collected baseline swab specimens for the detection of DNA of HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59 from 3 areas: penile, scrotal, and perineal/perianal. Risk factors for prevalent HPV DNA detection were evaluated. Results. The prevalence of any tested HPV type was 18.7% at the penis, 13.1% at the scrotum, 7.9% at the perineal/perianal region, and 21.0% at any site. Having >3 lifetime female sexual partners had the greatest impact on HPV prevalence: odds ratio (OR) 3.2 (95% confidence interval (CI) 2.1-4.9) for HPV 6, 11, 16, and 18; and OR 4.5 (95% CI 3.3-6.1) for all HPV types tested. HPV DNA detection was highest in Africa. Neither condom usage nor circumcision was associated with HPV DNA prevalence. Conclusion. Genital-HPV DNA detection is common in young, sexually active HM. We found HPV to be most prevalent in African men and least prevalent in men from the Asia-Pacific region. Increased numbers of sexual partners was an important risk factor for HPV DNA prevalence. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
dc.subjectvirus antibody
dc.subjectvirus DNA
dc.subjectWart virus vaccine
dc.subjectadolescent
dc.subjectadult
dc.subjectAfrica
dc.subjectanus
dc.subjectarticle
dc.subjectcircumcision
dc.subjectcondom
dc.subjectcondyloma acuminatum
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectheterosexual male
dc.subjecthuman
dc.subjectHuman papillomavirus type 11
dc.subjectHuman papillomavirus type 16
dc.subjectHuman papillomavirus type 18
dc.subjectHuman papillomavirus type 31
dc.subjectHuman papillomavirus type 33
dc.subjectHuman papillomavirus type 35
dc.subjectHuman papillomavirus type 39
dc.subjectHuman papillomavirus type 45
dc.subjectHuman papillomavirus type 51
dc.subjectHuman papillomavirus type 52
dc.subjectHuman papillomavirus type 56
dc.subjectHuman papillomavirus type 58
dc.subjectHuman papillomavirus type 59
dc.subjectHuman papillomavirus type 6
dc.subjectinfection risk
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpenis
dc.subjectperineum
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectscrotum
dc.subjectsexuality
dc.subjectvirus detection
dc.subjectWart virus
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnal Canal
dc.subjectAntibodies, Viral
dc.subjectDNA, Viral
dc.subjectGenital Diseases, Male
dc.subjectHeterosexuality
dc.subjectHumans
dc.subjectMale
dc.subjectPapillomaviridae
dc.subjectPapillomavirus Infections
dc.subjectPenis
dc.subjectPerineum
dc.subjectPrevalence
dc.subjectRisk Factors
dc.subjectScrotum
dc.subjectYoung Adult
dc.titleExternal genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents
dc.typeArticle
dc.description.versionArticle


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