Child with tuberculous meningitis and COVID-19 coinfection complicated by extensive cerebral sinus venous thrombosis

Essajee, Farida ; Solomons, Regan ; Goussard, Pierre ; Van Toorn, Ronald (2020-09-14)

CITATION: Essajee Farida et al. 2020. Child with tuberculous meningitis and COVID-19 coinfection complicated by extensive cerebral sinus venous thrombosis. BMJ Case Reports, 2020:13, doi:10.1136/bcr-2020-238597.

The original publication is available at: https://casereports.bmj.com

Article

We herein report a case of a child with tuberculous meningitis and COVID-19 coinfection complicated by hydrocephalus, arterial ischaemic stroke and extensive cerebral sinus venous thrombosis. Both conditions induce a proinflammatory cytokine drive resulting, among others, in a prothrombotic state. The disruption of the coagulation system in this case was supported by elevated D-dimers, fibrinogen and ferritin levels, consistent with thrombotic complications reported in some adult patients infected with COVID-19. The child also exhibited prolonged viral shedding that suggests severe disease.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/125178
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